STRINGSTRING
EIF2AK1 EIF2AK1 GBA GBA SOCS1 SOCS1 CSF2 CSF2 VEGFA VEGFA GAB3 GAB3 ENSCAFP00000043591 ENSCAFP00000043591 L3MBTL3 L3MBTL3 CSF1 CSF1 ZBTB46 ZBTB46 TSPAN2 TSPAN2 CD4 CD4 IFNG IFNG HLA-DQB1 HLA-DQB1 IL15 IL15 CEBPA CEBPA NKX2-3 NKX2-3 CEBPE CEBPE CASP8 CASP8 PIGX PIGX SIRT1 SIRT1 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa)
GBAGlucosylceramidase. (536 aa)
SOCS1Suppressor of cytokine signaling 1. (197 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (495 aa)
GAB3GRB2 associated binding protein 3. (190 aa)
ENSCAFP00000043591Uncharacterized protein. (176 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (694 aa)
CSF1Colony stimulating factor 1. (587 aa)
ZBTB46Zinc finger and BTB domain containing 46. (666 aa)
TSPAN2Tetraspanin. (304 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CEBPABZIP domain-containing protein. (159 aa)
NKX2-3NK2 homeobox 3. (365 aa)
CEBPECCAAT enhancer binding protein epsilon. (460 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (486 aa)
PIGXPhosphatidylinositol glycan anchor biosynthesis class X. (697 aa)
SIRT1Sirtuin 1. (745 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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