(47 nodes) Myofibril assembly network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MEF2A	Myocyte enhancer factor 2A. (609 aa)
	FLNC	Filamin C. (2720 aa)
	LMOD2	Leiomodin 2. (158 aa)
	SRF	Serum response factor. (508 aa)
	PGM5	Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (480 aa)
	TMOD1	Tropomodulin 1. (359 aa)
	MYLK3	Myosin light chain kinase 3. (850 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (820 aa)
	LMOD3	Leiomodin 3. (620 aa)
	ACTA1	Actin alpha 1, skeletal muscle. (377 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	LOC483676	Uncharacterized protein; Belongs to the actin family. (380 aa)
	CAPN3	Calpain 3; Belongs to the peptidase C2 family. (821 aa)
	ACTN2	Actinin alpha 2. (894 aa)
	ADPRH	ADP-ribosylarginine hydrolase. (362 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (443 aa)
	CAPN9	Calpain 9; Belongs to the peptidase C2 family. (692 aa)
	KLHL41	Kelch like family member 41. (606 aa)
	MYOZ2	Myozenin 2. (264 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	TMOD4	Tropomodulin 4. (345 aa)
	MYPN	Myopalladin. (1322 aa)
	MYOM2-2	Ig-like domain-containing protein. (623 aa)
	MYOZ1	Calsarcin 2. (297 aa)
	SYNPO2L	Synaptopodin 2 like. (1074 aa)
	WDR1	WD repeat domain 1. (609 aa)
	LDB3	LIM domain binding 3. (780 aa)
	NRAP	Nebulin related anchoring protein. (1728 aa)
	SIX4	SIX homeobox 4. (804 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (591 aa)
	TNNT2	Troponin T2, cardiac type. (296 aa)
	TCAP	Titin-cap. (210 aa)
	MYOM2	Uncharacterized protein. (1022 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (385 aa)
	ACTN1	Actinin alpha 1. (956 aa)
	ACTG2	Deoxyguanosine kinase. (521 aa)
	CSRP1	Cysteine and glycine rich protein 1. (201 aa)
	NEBL	Nebulette. (1017 aa)
	MYH6	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
	TNNT1	Troponin T1, slow skeletal type. (328 aa)
	TNNT3	Troponin T3, fast skeletal type. (340 aa)
	ADPRHL1	Uncharacterized protein. (352 aa)
	FLII	FLII actin remodeling protein. (1409 aa)
	ACTA2	Actin alpha 2, smooth muscle. (421 aa)
	TMOD2	Tropomodulin 2. (356 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa)
	CFL2	Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA1	ACTN2	ENSCAFP00000012116	ENSCAFP00000016032	Actin alpha 1, skeletal muscle.	Actinin alpha 2.	0.724
ACTA1	CFL2	ENSCAFP00000012116	ENSCAFP00000066617	Actin alpha 1, skeletal muscle.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.566
ACTA1	CSRP3	ENSCAFP00000012116	ENSCAFP00000013877	Actin alpha 1, skeletal muscle.	Cysteine and glycine rich protein 3.	0.592
ACTA1	LMOD3	ENSCAFP00000012116	ENSCAFP00000009775	Actin alpha 1, skeletal muscle.	Leiomodin 3.	0.519
ACTA1	MYH6	ENSCAFP00000012116	ENSCAFP00000053932	Actin alpha 1, skeletal muscle.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.977
ACTA1	TNNT1	ENSCAFP00000012116	ENSCAFP00000055435	Actin alpha 1, skeletal muscle.	Troponin T1, slow skeletal type.	0.495
ACTA1	TNNT3	ENSCAFP00000012116	ENSCAFP00000056461	Actin alpha 1, skeletal muscle.	Troponin T3, fast skeletal type.	0.514
ACTA1	WDR1	ENSCAFP00000012116	ENSCAFP00000022857	Actin alpha 1, skeletal muscle.	WD repeat domain 1.	0.425
ACTA2	ACTN1	ENSCAFP00000061973	ENSCAFP00000048269	Actin alpha 2, smooth muscle.	Actinin alpha 1.	0.439
ACTA2	ACTN2	ENSCAFP00000061973	ENSCAFP00000016032	Actin alpha 2, smooth muscle.	Actinin alpha 2.	0.688
ACTA2	CFL2	ENSCAFP00000061973	ENSCAFP00000066617	Actin alpha 2, smooth muscle.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.404
ACTA2	MYH6	ENSCAFP00000061973	ENSCAFP00000053932	Actin alpha 2, smooth muscle.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.950
ACTA2	WDR1	ENSCAFP00000061973	ENSCAFP00000022857	Actin alpha 2, smooth muscle.	WD repeat domain 1.	0.425
ACTG2	ACTN1	ENSCAFP00000048517	ENSCAFP00000048269	Deoxyguanosine kinase.	Actinin alpha 1.	0.517
ACTG2	ACTN2	ENSCAFP00000048517	ENSCAFP00000016032	Deoxyguanosine kinase.	Actinin alpha 2.	0.711
ACTG2	CFL2	ENSCAFP00000048517	ENSCAFP00000066617	Deoxyguanosine kinase.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.407
ACTG2	CSRP3	ENSCAFP00000048517	ENSCAFP00000013877	Deoxyguanosine kinase.	Cysteine and glycine rich protein 3.	0.410
ACTG2	MYH6	ENSCAFP00000048517	ENSCAFP00000053932	Deoxyguanosine kinase.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.950
ACTG2	MYPN	ENSCAFP00000048517	ENSCAFP00000019952	Deoxyguanosine kinase.	Myopalladin.	0.434
ACTG2	WDR1	ENSCAFP00000048517	ENSCAFP00000022857	Deoxyguanosine kinase.	WD repeat domain 1.	0.433