STRINGSTRING
OSR2 OSR2 PITX1 PITX1 DLX5 DLX5 HOXA9 HOXA9 HOXA11 HOXA11 HOXA13 HOXA13 WDPCP WDPCP GLI3 GLI3 OSR1 OSR1 INTU INTU MEGF8 MEGF8 FREM2 FREM2 HOXC10 HOXC10 HOXC11 HOXC11 IMPAD1 IMPAD1 CHD7 CHD7 HAND2 HAND2 GDF5 GDF5 GREM1 GREM1 SFRP2 SFRP2 CYP26B1 CYP26B1 TBX5 TBX5 IFT52 IFT52 ALX4 ALX4 SALL1 SALL1 HNF1A HNF1A NOTCH2 NOTCH2 LRP5 LRP5 GJA5 GJA5 SALL4 SALL4 FLVCR1 FLVCR1 MAP3K20 MAP3K20 SP9 SP9 LNPK LNPK HOXD10 HOXD10 ZBTB16 ZBTB16 TP63 TP63 BMP4 BMP4 TULP3 TULP3 MSX1 MSX1 BMPR1A BMPR1A WDR19 WDR19 MED1 MED1 TMEM107 TMEM107 TBX4 TBX4 B9D1 B9D1 GPC3 GPC3 IFT140 IFT140 NOTCH1 NOTCH1 ALX3 ALX3 TMEM231 TMEM231 GAS1 GAS1 HOXD12 HOXD12 TBX2 TBX2 GNA12 GNA12 NIPBL NIPBL FGF4 FGF4 CHST11 CHST11 FRAS1 FRAS1 RPGRIP1L RPGRIP1L LRP4 LRP4 RUNX2 RUNX2 TBX3 TBX3 SP8 SP8 FGF9 FGF9 BCL2L11 BCL2L11 ECE1 ECE1 SHH SHH TFAP2A TFAP2A SMAD4 SMAD4 RECK RECK PTCH1 PTCH1 LMBR1 LMBR1 LEF1 LEF1 TBC1D32 TBC1D32 ALDH1A2 ALDH1A2 RDH10 RDH10 RARG RARG DLX6 DLX6 MKS1 MKS1 LOC111095293 LOC111095293 RARB RARB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OSR2Odd-skipped related transciption factor 2. (312 aa)
PITX1Homeobox protein. (313 aa)
DLX5Distal-less homeobox 5. (289 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
HOXA11Homeobox A11. (314 aa)
HOXA13Homeobox A13. (389 aa)
WDPCPWD repeat containing planar cell polarity effector. (720 aa)
GLI3GLI family zinc finger 3. (1590 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
INTUInturned planar cell polarity protein. (941 aa)
MEGF8Multiple EGF like domains 8. (439 aa)
FREM2FRAS1 related extracellular matrix 2. (3168 aa)
HOXC10Homeobox C13. (342 aa)
HOXC11Homeobox C11. (305 aa)
IMPAD1Inositol monophosphatase domain containing 1. (360 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
HAND2Heart and neural crest derivatives expressed 2. (256 aa)
GDF5Growth differentiation factor 5. (499 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (230 aa)
SFRP2Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. (253 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
TBX5T-box transcription factor 5. (519 aa)
IFT52Intraflagellar transport 52. (446 aa)
ALX4ALX homeobox 4. (414 aa)
SALL1Spalt like transcription factor 1. (1324 aa)
HNF1AHNF1 homeobox A. (638 aa)
NOTCH2Notch receptor 2. (2726 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1583 aa)
GJA5Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
SALL4Spalt like transcription factor 4. (1054 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (577 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
SP9Sp9 transcription factor. (309 aa)
LNPKLunapark, ER junction formation factor. (429 aa)
HOXD10Homeobox D10. (410 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (462 aa)
MSX1Msh homeobox 1. (276 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WDR19WD repeat domain 19. (1182 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
TMEM107Transmembrane protein 107. (140 aa)
TBX4T-box transcription factor TBX4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation (By similarity). (554 aa)
B9D1B9 domain containing 1. (337 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (613 aa)
IFT140Uncharacterized protein. (656 aa)
NOTCH1Notch receptor 1. (2565 aa)
ALX3ALX homeobox 3. (200 aa)
TMEM231Transmembrane protein 231. (316 aa)
GAS1Growth arrest specific 1. (385 aa)
HOXD12Homeobox D12. (270 aa)
TBX2T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). (655 aa)
GNA12G protein subunit alpha 12. (294 aa)
NIPBLNipped-B protein. (2804 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CHST11Carbohydrate sulfotransferase. (368 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4011 aa)
RPGRIP1LRPGRIP1 like. (1278 aa)
LRP4LDL receptor related protein 4. (1953 aa)
RUNX2RUNX family transcription factor 2. (476 aa)
TBX3T-box transcription factor 3. (720 aa)
SP8Uncharacterized protein. (285 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
BCL2L11BCL2 like 11. (301 aa)
ECE1Endothelin converting enzyme 1. (792 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (593 aa)
TFAP2ATranscription factor AP-2 alpha. (442 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
PTCH1Patched 1. (1449 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (505 aa)
LEF1Lymphoid enhancer binding factor 1. (481 aa)
TBC1D32TBC1 domain family member 32. (1341 aa)
ALDH1A2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (555 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (367 aa)
RARGRetinoic acid receptor gamma. (628 aa)
DLX6Distal-less homeobox 6. (248 aa)
MKS1MKS transition zone complex subunit 1. (580 aa)
LOC111095293Uncharacterized protein. (138 aa)
RARBRetinoic acid receptor beta. (464 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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