STRINGSTRING
DSG1 DSG1 HIVEP1 HIVEP1 SMAD2 SMAD2 FAM83G FAM83G USP9X USP9X ENSCAFP00000058542 ENSCAFP00000058542 ENSCAFP00000056905 ENSCAFP00000056905 LEF1 LEF1 COMP COMP ACVR2A ACVR2A ENSCAFP00000053603 ENSCAFP00000053603 SMAD4 SMAD4 DLX3 DLX3 CHRDL1 CHRDL1 FST FST BMP2 BMP2 MAPK3-2 MAPK3-2 ACVRL1 ACVRL1 ACVR1 ACVR1 HFE HFE BMPR1B BMPR1B TWSG1 TWSG1 SOST SOST RUNX2 RUNX2 CHRD CHRD GDF3 GDF3 ZNF831 ZNF831 BMP7 BMP7 SOSTDC1 SOSTDC1 GDF7 GDF7 NODAL NODAL BMP6 BMP6 PDCD4 PDCD4 SFRP1 SFRP1 ZNF8 ZNF8 BMPR2 BMPR2 ZCCHC18 ZCCHC18 SMPD3 SMPD3 TGFBR3 TGFBR3 ABL1 ABL1 HES5 HES5 SMAD7 SMAD7 F1PXS7_CANLF F1PXS7_CANLF SMAD3 SMAD3 TMEM100 TMEM100 SMAD6 SMAD6 MAPK3 MAPK3 TGFB3 TGFB3 GDF2 GDF2 LOC490387 LOC490387 BMPR1A BMPR1A MSX1 MSX1 SMURF1 SMURF1 GDF15 GDF15 BMP4 BMP4 F1P910_CANLF F1P910_CANLF NANOG NANOG ATF2 ATF2 DDX5 DDX5 HJV HJV RGMA RGMA NOTCH2 NOTCH2 SLC33A1 SLC33A1 CCDC142 CCDC142 SFRP2 SFRP2 GDF5 GDF5 SMAD1 SMAD1 SPART SPART SMAD9 SMAD9 ACVR2B ACVR2B B9D2 B9D2 MEGF8 MEGF8 BMP10 BMP10 BMPER BMPER LOC100855618 LOC100855618 BMP5 BMP5 DLX5 DLX5 TMPRSS6 TMPRSS6 EGR1 EGR1 SMAD5 SMAD5 EXT1 EXT1 USP15 USP15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DSG1Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1353 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2731 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FAM83GFamily with sequence similarity 83 member G. (861 aa)
USP9XUCH domain-containing protein. (1895 aa)
ENSCAFP00000058542Uncharacterized protein. (120 aa)
ENSCAFP00000056905TGF_BETA_2 domain-containing protein. (398 aa)
LEF1Lymphoid enhancer binding factor 1. (481 aa)
COMPCartilage oligomeric matrix protein. (891 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (735 aa)
ENSCAFP00000053603Uncharacterized protein. (96 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DLX3Distal-less homeobox 3. (319 aa)
CHRDL1Chordin like 1. (511 aa)
FSTFollistatin. (237 aa)
BMP2Bone morphogenetic protein 2. (436 aa)
MAPK3-2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (504 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (247 aa)
SOSTSclerostin. (213 aa)
RUNX2RUNX family transcription factor 2. (476 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (959 aa)
GDF3Growth differentiation factor 3. (365 aa)
ZNF831Zinc finger protein 831. (1653 aa)
BMP7Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). (653 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
GDF7TGF_BETA_2 domain-containing protein. (755 aa)
NODALNodal growth differentiation factor. (378 aa)
BMP6Bone morphogenetic protein 6. (335 aa)
PDCD4Programmed cell death 4. (469 aa)
SFRP1Secreted frizzled related protein 1. (458 aa)
ZNF8Zinc finger protein 8. (576 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
ZCCHC18Uncharacterized protein. (371 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
F1PXS7_CANLFProtein kinase domain-containing protein. (232 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
TMEM100Transmembrane protein 100. (134 aa)
SMAD6Mothers against decapentaplegic homolog. (499 aa)
MAPK3Mitogen-activated protein kinase. (283 aa)
TGFB3Transforming growth factor beta 3. (457 aa)
GDF2Growth differentiation factor 2. (420 aa)
LOC490387Left-right determination factor. (367 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MSX1Msh homeobox 1. (276 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (712 aa)
GDF15Growth differentiation factor 15. (307 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
F1P910_CANLFUSP domain-containing protein; Belongs to the peptidase C19 family. (646 aa)
NANOGHomeobox domain-containing protein. (304 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DDX5Uncharacterized protein; Belongs to the DEAD box helicase family. (614 aa)
HJVHemojuvelin BMP co-receptor. (469 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (422 aa)
NOTCH2Notch receptor 2. (2726 aa)
SLC33A1Solute carrier family 33 member 1. (551 aa)
CCDC142Coiled-coil domain containing 142. (749 aa)
SFRP2Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. (253 aa)
GDF5Growth differentiation factor 5. (499 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SPARTSpartin. (750 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
MEGF8Multiple EGF like domains 8. (439 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BMPERBMP binding endothelial regulator. (741 aa)
LOC100855618TGF_BETA_2 domain-containing protein. (297 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
DLX5Distal-less homeobox 5. (289 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (802 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (1109 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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