STRINGSTRING
SMAD4 SMAD4 NOTCH1 NOTCH1 HES5 HES5 GPC3 GPC3 RNF165 RNF165 GDF2 GDF2 MSX1 MSX1 BMP4 BMP4 NOTCH2 NOTCH2 FBXL15 FBXL15 ZNF423 ZNF423 GDF5 GDF5 SULF1 SULF1 UBE2O UBE2O KDR KDR KIAA1324L KIAA1324L NUMA1 NUMA1 NEO1 NEO1 ACVRL1 ACVRL1 TWSG1 TWSG1 ENG ENG SCUBE3 SCUBE3 TBX20 TBX20 ILK ILK BMPR2 BMPR2 CDH5 CDH5 CCN1 CCN1 KCP KCP CRB2 CRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NOTCH1Notch receptor 1. (2565 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (613 aa)
RNF165Ring finger protein 165. (346 aa)
GDF2Growth differentiation factor 2. (420 aa)
MSX1Msh homeobox 1. (276 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
NOTCH2Notch receptor 2. (2726 aa)
FBXL15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. (300 aa)
ZNF423Zinc finger protein 423. (1284 aa)
GDF5Growth differentiation factor 5. (499 aa)
SULF1Sulfatase 1. (1146 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1290 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
KIAA1324LKIAA1324 like. (1007 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2089 aa)
NEO1Neogenin 1. (1551 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (247 aa)
ENGEndoglin. (652 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (1009 aa)
TBX20T-box transcription factor 20. (448 aa)
ILKIntegrin linked kinase. (452 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (775 aa)
CCN1Cellular communication network factor 1. (385 aa)
KCPKielin cysteine rich BMP regulator. (1686 aa)
CRB2Crumbs cell polarity complex component 2. (1285 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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