Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADA | IL2 | ENSCAFP00000063170 | ENSCAFP00000005941 | Adenosine deaminase. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.595 |
| ATM | BMI1 | ENSCAFP00000035996 | ENSCAFP00000050138 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | RING-type domain-containing protein. | 0.470 |
| ATM | CDKN1A | ENSCAFP00000035996 | ENSCAFP00000050190 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cyclin dependent kinase inhibitor 1A. | 0.517 |
| ATM | PTEN | ENSCAFP00000035996 | ENSCAFP00000045099 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.646 |
| BCL6 | CD38 | ENSCAFP00000020491 | ENSCAFP00000042321 | B-cell lymphoma 6 protein. | CD38 molecule. | 0.774 |
| BCL6 | CDKN1A | ENSCAFP00000020491 | ENSCAFP00000050190 | B-cell lymphoma 6 protein. | Cyclin dependent kinase inhibitor 1A. | 0.472 |
| BCL6 | GPR183 | ENSCAFP00000020491 | ENSCAFP00000008673 | B-cell lymphoma 6 protein. | G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. | 0.483 |
| BCL6 | IL10 | ENSCAFP00000020491 | ENSCAFP00000016812 | B-cell lymphoma 6 protein. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.524 |
| BCL6 | IL2 | ENSCAFP00000020491 | ENSCAFP00000005941 | B-cell lymphoma 6 protein. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.535 |
| BCL6 | IL21 | ENSCAFP00000020491 | ENSCAFP00000005939 | B-cell lymphoma 6 protein. | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] | 0.564 |
| BCL6 | IL4 | ENSCAFP00000020491 | ENSCAFP00000001253 | B-cell lymphoma 6 protein. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.778 |
| BLK | CD22 | ENSCAFP00000011788 | ENSCAFP00000010457 | Tyrosine-protein kinase. | CD22 molecule. | 0.474 |
| BMI1 | ATM | ENSCAFP00000050138 | ENSCAFP00000035996 | RING-type domain-containing protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.470 |
| BMI1 | PTEN | ENSCAFP00000050138 | ENSCAFP00000045099 | RING-type domain-containing protein. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.602 |
| BST1 | CD38 | ENSCAFP00000022572 | ENSCAFP00000042321 | Bone marrow stromal cell antigen 1. | CD38 molecule. | 0.908 |
| BTK | CARD11 | ENSCAFP00000043729 | ENSCAFP00000023996 | Tyrosine-protein kinase. | Caspase recruitment domain family member 11. | 0.584 |
| BTK | CD22 | ENSCAFP00000043729 | ENSCAFP00000010457 | Tyrosine-protein kinase. | CD22 molecule. | 0.630 |
| BTK | CD38 | ENSCAFP00000043729 | ENSCAFP00000042321 | Tyrosine-protein kinase. | CD38 molecule. | 0.423 |
| BTK | LYN | ENSCAFP00000043729 | ENSCAFP00000046785 | Tyrosine-protein kinase. | Tyrosine-protein kinase. | 0.960 |
| BTK | NCKAP1L | ENSCAFP00000043729 | ENSCAFP00000009656 | Tyrosine-protein kinase. | NCK associated protein 1 like. | 0.465 |
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