29 items (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	TCP1	T-complex 1. (556 aa)
	POT1	Protection of telomeres 1. (785 aa)
	CCT4	T-complex protein 1 subunit delta. (539 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
	MAPK3	Mitogen-activated protein kinase. (283 aa)
	FBXO4	F-box protein 4. (387 aa)
	F1PXS7_CANLF	Protein kinase domain-containing protein. (232 aa)
	DKC1	Dyskerin pseudouridine synthase 1. (683 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (455 aa)
	NEK2	NIMA related kinase 2. (444 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	LOC100856782	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (502 aa)
	XRCC5	X-ray repair cross complementing 5. (829 aa)
	ENSCAFP00000046424	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (460 aa)
	MAPK3-2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	ENSCAFP00000050117	Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (124 aa)
	ENSCAFP00000053214	Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (442 aa)
	ENSCAFP00000053944	Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (183 aa)
	ENSCAFP00000056003	Uncharacterized protein. (326 aa)
	NEK7	NIMA related kinase 7; Belongs to the protein kinase superfamily. (338 aa)
	ENSCAFP00000060330	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (524 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (589 aa)
	PARN	Poly(A)-specific ribonuclease. (665 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1679 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	DKC1	ENSCAFP00000032488	ENSCAFP00000029020	ACD shelterin complex subunit and telomerase recruitment factor.	Dyskerin pseudouridine synthase 1.	0.563
ACD	POT1	ENSCAFP00000032488	ENSCAFP00000002549	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres 1.	0.994
ATM	POT1	ENSCAFP00000035996	ENSCAFP00000002549	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protection of telomeres 1.	0.402
ATM	XRCC5	ENSCAFP00000035996	ENSCAFP00000038467	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 5.	0.882
CCT2	CCT3	ENSCAFP00000000628	ENSCAFP00000034400	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit gamma.	0.995
CCT2	CCT4	ENSCAFP00000000628	ENSCAFP00000004593	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit delta.	0.996
CCT2	CCT7	ENSCAFP00000000628	ENSCAFP00000013064	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.910
CCT2	ENSCAFP00000046424	ENSCAFP00000000628	ENSCAFP00000046424	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.794
CCT2	ENSCAFP00000060330	ENSCAFP00000000628	ENSCAFP00000060330	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.794
CCT2	LOC100856782	ENSCAFP00000000628	ENSCAFP00000036362	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.871
CCT2	TCP1	ENSCAFP00000000628	ENSCAFP00000001046	Chaperonin containing TCP1 subunit 2.	T-complex 1.	0.986
CCT3	CCT2	ENSCAFP00000034400	ENSCAFP00000000628	T-complex protein 1 subunit gamma.	Chaperonin containing TCP1 subunit 2.	0.995
CCT3	CCT4	ENSCAFP00000034400	ENSCAFP00000004593	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.999
CCT3	CCT7	ENSCAFP00000034400	ENSCAFP00000013064	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.985
CCT3	ENSCAFP00000046424	ENSCAFP00000034400	ENSCAFP00000046424	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.956
CCT3	ENSCAFP00000050117	ENSCAFP00000034400	ENSCAFP00000050117	T-complex protein 1 subunit gamma.	Uncharacterized protein; Belongs to the TCP-1 chaperonin family.	0.964
CCT3	ENSCAFP00000053214	ENSCAFP00000034400	ENSCAFP00000053214	T-complex protein 1 subunit gamma.	Uncharacterized protein; Belongs to the TCP-1 chaperonin family.	0.964
CCT3	ENSCAFP00000053944	ENSCAFP00000034400	ENSCAFP00000053944	T-complex protein 1 subunit gamma.	Uncharacterized protein; Belongs to the TCP-1 chaperonin family.	0.964
CCT3	ENSCAFP00000056003	ENSCAFP00000034400	ENSCAFP00000056003	T-complex protein 1 subunit gamma.	Uncharacterized protein.	0.964
CCT3	ENSCAFP00000060330	ENSCAFP00000034400	ENSCAFP00000060330	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.956