STRINGSTRING
DSCC1 DSCC1 C9H17orf64 C9H17orf64 SUB1 SUB1 RPA1 RPA1 HFM1 HFM1 HELB HELB MCM7 MCM7 CHD4 CHD4 NBN NBN CHD3 CHD3 MCM9 MCM9 ERCC2 ERCC2 POT1 POT1 ANXA1 ANXA1 MCM3 MCM3 SLFNL1 SLFNL1 ASCC3 ASCC3 RUVBL2 RUVBL2 SSBP1 SSBP1 RUVBL1 RUVBL1 MRE11 MRE11 ERCC3 ERCC3 GTF2F2 GTF2F2 RECQL5 RECQL5 CHTF18 CHTF18 MCM6 MCM6 FBH1 FBH1 GINS4 GINS4 PURA PURA RFC3 RFC3 WRN WRN MCM4 MCM4 CHD7 CHD7 MCMDC2 MCMDC2 CHD1 CHD1 DQX1 DQX1 GINS3 GINS3 DHX36 DHX36 WRNIP1 WRNIP1 CHD9 CHD9 TWNK TWNK IGHMBP2 IGHMBP2 CHD1L CHD1L CHD2 CHD2 POLQ POLQ BLM BLM DHX32 DHX32 TM4SF19 TM4SF19 DHX9 DHX9 RFC4 RFC4 XRCC5 XRCC5 CHD6 CHD6 RFC2 RFC2 MCM5 MCM5 TREX1 TREX1 GINS2 GINS2 LOC100855532 LOC100855532 HELQ HELQ ERCC6L ERCC6L RAD50 RAD50 NAV2 NAV2 MCM8 MCM8 RECQL RECQL RAD51 RAD51 XRCC6 XRCC6 RTEL1 RTEL1 ENSCAFP00000057080 ENSCAFP00000057080 DDX3X DDX3X DDX1 DDX1 G3BP1 G3BP1 CHD5 CHD5 DDX11 DDX11 DNA2 DNA2 SUPV3L1 SUPV3L1 CDC45 CDC45 UPF1 UPF1 FANCM FANCM MCM2 MCM2 CHTF8 CHTF8 SMARCAD1 SMARCAD1 ENSCAFP00000044735 ENSCAFP00000044735 CHD8 CHD8 ATRX ATRX BRIP1 BRIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DSCC1DNA replication and sister chromatid cohesion 1. (392 aa)
C9H17orf64Chromosome 9 C17orf64 homolog. (235 aa)
SUB1SUB1 regulator of transcription. (127 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
HFM1Helicase for meiosis 1. (1481 aa)
HELBDNA helicase B. (1135 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1984 aa)
NBNNibrin. (886 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1977 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (764 aa)
POT1Protection of telomeres 1. (785 aa)
ANXA1Annexin. (345 aa)
MCM3Minichromosome maintenance complex component 3; Belongs to the MCM family. (817 aa)
SLFNL1Schlafen like 1. (347 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2202 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (779 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa)
CHTF18Chromosome transmission fidelity factor 18. (1107 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
FBH1F-box DNA helicase 1. (1046 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (291 aa)
PURAPurine rich element binding protein A. (469 aa)
RFC3Replication factor C subunit 3. (356 aa)
WRNWRN RecQ like helicase. (1574 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1711 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (719 aa)
GINS3GINS complex subunit 3. (216 aa)
DHX36DEAH-box helicase 36. (1122 aa)
WRNIP1Werner helicase interacting protein 1. (445 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2902 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (1040 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (883 aa)
CHD2Chromodomain helicase DNA binding protein 2. (1827 aa)
POLQDNA polymerase theta. (2704 aa)
BLMBLM RecQ like helicase. (1420 aa)
DHX32DEAH-box helicase 32 (putative). (745 aa)
TM4SF19Uncharacterized protein. (209 aa)
DHX9DExH-box helicase 9. (1276 aa)
RFC4Replication factor C subunit 4. (363 aa)
XRCC5X-ray repair cross complementing 5. (829 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2715 aa)
RFC2Replication factor C subunit 2. (367 aa)
MCM5Minichromosome maintenance complex component 5; Belongs to the MCM family. (689 aa)
TREX1Three prime repair exonuclease 1. (373 aa)
GINS2GINS complex subunit 2. (198 aa)
LOC100855532Single-stranded DNA-binding protein, mitochondrial. (148 aa)
HELQHelicase, POLQ like. (1072 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1268 aa)
RAD50RAD50 double strand break repair protein. (1312 aa)
NAV2Neuron navigator 2. (2446 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (848 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (646 aa)
RAD51DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa)
XRCC6X-ray repair cross complementing 6. (612 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1416 aa)
ENSCAFP00000057080Uncharacterized protein. (104 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (663 aa)
DDX1DEAD-box helicase 1. (784 aa)
G3BP1G3BP stress granule assembly factor 1. (461 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1986 aa)
DDX11DEAD/H-box helicase 11. (1044 aa)
DNA2DNA replication helicase/nuclease 2. (1017 aa)
SUPV3L1Suv3 like RNA helicase. (845 aa)
CDC45Cell division cycle 45. (569 aa)
UPF1UPF1 RNA helicase and ATPase. (1130 aa)
FANCMFA complementation group M. (2047 aa)
MCM2DNA helicase; Belongs to the MCM family. (933 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
SMARCAD1Uncharacterized protein. (998 aa)
ENSCAFP00000044735annotation not available (148 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2625 aa)
ATRXATRX chromatin remodeler. (2489 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1243 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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