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| | DKC1 | Dyskerin pseudouridine synthase 1. (683 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (1143 aa) |
| | HASPIN | Histone H3 associated protein kinase. (781 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1754 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1412 aa) |
| | F1PXS7_CANLF | Protein kinase domain-containing protein. (232 aa) |
| | RMI2 | RecQ mediated genome instability 2. (156 aa) |
| | PSMG2 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (902 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | NDC80 | NDC80 kinetochore complex component. (642 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | CENPV | Centromere protein V. (205 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1584 aa) |
| | INO80C | INO80 complex subunit C. (192 aa) |
| | ZWILCH | Zwilch kinetochore protein. (587 aa) |
| | ATRX | ATRX chromatin remodeler. (2489 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (272 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (283 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1079 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (740 aa) |
| | MAD2L1 | HORMA domain-containing protein. (267 aa) |
| | TSR2 | G protein nucleolar 3 like. (649 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | WAPL | WAPL cohesin release factor. (1287 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (805 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1400 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1130 aa) |
| | CDCA5 | Cell division cycle associated 5. (251 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2361 aa) |
| | CDC27 | Cell division cycle 27. (831 aa) |
| | ZW10 | Zw10 kinetochore protein. (779 aa) |
| | INO80D | INO80 complex subunit D. (1029 aa) |
| | SHCBP1L | SHC binding and spindle associated 1 like. (638 aa) |
| | ATF7IP | Activating transcription factor 7 interacting protein. (1264 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (331 aa) |
| | AXIN2 | Axin 2. (843 aa) |
| | CENPE | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2774 aa) |
| | TRIP13 | Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] (432 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (328 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (746 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1311 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1170 aa) |
| | INO80 | INO80 complex ATPase subunit. (1560 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (615 aa) |
| | GNL3 | G protein nucleolar 3. (555 aa) |
| | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B. (1063 aa) |
| | CCT7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa) |
| | DHX36 | DEAH-box helicase 36. (1122 aa) |
| | INO80B | PAPA-1 domain-containing protein. (356 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (423 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (956 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (431 aa) |
| | RIOK2 | RIO kinase 2. (548 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | MPHOSPH8 | Uncharacterized protein. (860 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1316 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | NCAPH | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (728 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | USP44 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (711 aa) |
| | CHFR | Checkpoint with forkhead and ring finger domains. (726 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | IK | IK cytokine. (547 aa) |
| | ANAPC11 | Anaphase promoting complex subunit 11. (458 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (155 aa) |
| | CTNNB1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa) |
| | CCDC174 | Coiled-coil domain containing 174. (465 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | MYCN | BHLH domain-containing protein. (180 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (702 aa) |
| | CDK5RAP2 | CDK5 regulatory subunit associated protein 2. (1826 aa) |
| | TRAPPC12 | Trafficking protein particle complex 12. (786 aa) |
| | CCT4 | T-complex protein 1 subunit delta. (539 aa) |
| | TTK | TTK protein kinase. (908 aa) |
| | SENP6 | SUMO specific peptidase 6. (1145 aa) |
| | RPS9 | TCF3 fusion partner. (253 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1191 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (274 aa) |
| | POT1 | Protection of telomeres 1. (785 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | F1PQZ0_CANLF | Uncharacterized protein. (125 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | TCP1 | T-complex 1. (556 aa) |
| | CCT2 | Chaperonin containing TCP1 subunit 2. (535 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (940 aa) |
| | KNTC1 | Kinetochore associated 1. (2213 aa) |
| | ENSCAFP00000066602 | Histone domain-containing protein. (132 aa) |
| | ENSCAFP00000066593 | C2H2-type domain-containing protein. (495 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1679 aa) |
| | ENSCAFP00000065566 | Histone domain-containing protein. (117 aa) |
| | PARN | Poly(A)-specific ribonuclease. (665 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa) |
| | ENSCAFP00000064886 | Uncharacterized protein. (246 aa) |
| | XRCC1 | Uncharacterized protein. (664 aa) |
| | ENSCAFP00000063758 | RIO domain-containing protein. (348 aa) |
| | ENSCAFP00000062039 | Uncharacterized protein. (273 aa) |
| | ENSCAFP00000061810 | HORMA domain-containing protein. (136 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (589 aa) |
| | DYNC1LI1 | Dynein cytoplasmic 1 light intermediate chain 1. (733 aa) |
| | ENSCAFP00000060330 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (524 aa) |
| | FAM178B | Family with sequence similarity 178 member B. (364 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1245 aa) |
| | ENSCAFP00000059433 | HORMA domain-containing protein. (354 aa) |
| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (338 aa) |
| | ENSCAFP00000059003 | Uncharacterized protein. (87 aa) |
| | MNAT1 | MNAT1 component of CDK activating kinase. (358 aa) |
| | SETDB2 | SET domain bifurcated histone lysine methyltransferase 2. (705 aa) |
| | PCID2 | PCI domain containing 2. (410 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1325 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (704 aa) |
| | RB1 | RB transcriptional corepressor 1. (927 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1973 aa) |
| | ENSCAFP00000056003 | Uncharacterized protein. (326 aa) |
| | WBP1 | WW domain binding protein 1. (301 aa) |
| | ENSCAFP00000053944 | Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (183 aa) |
| | ENSCAFP00000053214 | Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (442 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (399 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2089 aa) |
| | CTC1 | CST telomere replication complex component 1. (1236 aa) |
| | ENSCAFP00000050766 | G-patch domain-containing protein. (280 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (540 aa) |
| | ENSCAFP00000050117 | Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (124 aa) |
| | PML | Promyelocytic leukemia. (933 aa) |
| | APC | APC regulator of WNT signaling pathway. (2851 aa) |
| | MAPK3-2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | LOC100855532 | Single-stranded DNA-binding protein, mitochondrial. (148 aa) |
| | FBXO42 | F-box protein 42. (746 aa) |
| | BECN1 | Beclin 1. (471 aa) |
| | ENSCAFP00000046424 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (460 aa) |
| | EXOSC10 | Exosome component 10. (960 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (533 aa) |
| | GALK1 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. (431 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (265 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (725 aa) |
| | LOC102155487 | ANK_REP_REGION domain-containing protein. (362 aa) |
| | ENSCAFP00000044735 | annotation not available (148 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (233 aa) |
| | PTTG1 | Uncharacterized protein. (207 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1541 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1483 aa) |
| | KHDC3L | KH domain containing 3 like, subcortical maternal complex member. (384 aa) |
| | LCMT1 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (333 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (933 aa) |
| | PTPN9 | SIN3 transcription regulator family member A. (1303 aa) |
| | SMC5 | Structural maintenance of chromosomes 5. (1106 aa) |
| | ATF7IP2 | Activating transcription factor 7 interacting protein 2. (683 aa) |
| | SETDB1 | SET domain bifurcated histone lysine methyltransferase 1. (1294 aa) |
| | HDAC8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (415 aa) |
| | YLPM1 | YLP motif containing 1. (2149 aa) |
| | MORC2 | MORC family CW-type zinc finger 2. (1075 aa) |
| | MCRS1 | Microspherule protein 1. (518 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | RAD50 | RAD50 double strand break repair protein. (1312 aa) |
| | LOC612779 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | TEN1 | TEN1 subunit of CST complex. (121 aa) |
| | TASOR | Transcription activation suppressor. (1675 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (604 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (738 aa) |
| | SIRT6 | Sirtuin 6. (403 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (829 aa) |
| | FBXO5 | F-box protein 5. (447 aa) |
| | NEK6 | NIMA related kinase 6; Belongs to the protein kinase superfamily. (380 aa) |
| | NBN | Nibrin. (886 aa) |
| | ZNF304 | Zinc finger protein 304. (660 aa) |
| | DCP2 | Decapping mRNA 2. (422 aa) |
| | NABP2 | Nucleic acid binding protein 2. (280 aa) |
| | LOC480110 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3651 aa) |
| | LOC100856782 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (502 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (452 aa) |
| | RESF1 | Retroelement silencing factor 1. (1739 aa) |
| | CCT3 | T-complex protein 1 subunit gamma. (545 aa) |
| | NEK2 | NIMA related kinase 2. (444 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (455 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | TERF2IP | TERF2 interacting protein. (403 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (769 aa) |
