(44 nodes) Cellular response to amino acid starvation network (Canis lupus familiaris)

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Your Input:
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (869 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (369 aa)
	SESN3	Sestrin 3. (573 aa)
	WDR59	WD repeat domain 59. (989 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3464 aa)
	ENSCAFP00000063173	Uncharacterized protein. (97 aa)
	RRAGA	Ras related GTP binding A. (595 aa)
	TFEB	Transcription factor EB. (566 aa)
	LARS1	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1224 aa)
	DAP	Uncharacterized protein. (102 aa)
	SESN1	Sestrin 1. (658 aa)
	ENSCAFP00000050545	Uncharacterized protein. (74 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (357 aa)
	DEPDC5	DEP domain containing 5. (1646 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (744 aa)
	MAPK3-2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	IMPACT	Impact RWD domain protein. (421 aa)
	SESN2	Sestrin 2. (485 aa)
	C10H12orf66	Chromosome 10 C12orf66 homolog. (445 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
	RNF152	Ring finger protein 152. (203 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (487 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	WDR24	WD repeat domain 24. (735 aa)
	F1PXS7_CANLF	Protein kinase domain-containing protein. (232 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (748 aa)
	MAPK3	Mitogen-activated protein kinase. (283 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
	RRAGB	Ras related GTP binding B. (374 aa)
	FAS	Fas cell surface death receptor. (734 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	ATF3	Activating transcription factor 3. (267 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (380 aa)
	GCN1	GCN1 activator of EIF2AK4. (2671 aa)
	DAPL1	Death associated protein like 1. (107 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1113 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2-alpha kinase 2. (532 aa)
	KPTN	Kaptin, actin binding protein. (539 aa)
	RRAGD	Ras related GTP binding D. (385 aa)
	MIOS	Meiosis regulator for oocyte development. (875 aa)
	ATF4	Activating transcription factor 4. (350 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1366 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF2	ATF3	ENSCAFP00000019690	ENSCAFP00000018170	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 3.	0.446
ATF2	ATF4	ENSCAFP00000019690	ENSCAFP00000001900	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 4.	0.918
ATF2	F1PXS7_CANLF	ENSCAFP00000019690	ENSCAFP00000028002	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Protein kinase domain-containing protein.	0.446
ATF2	MAPK1	ENSCAFP00000019690	ENSCAFP00000030998	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.953
ATF2	MAPK3	ENSCAFP00000019690	ENSCAFP00000025190	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Mitogen-activated protein kinase.	0.653
ATF2	MAPK3-2	ENSCAFP00000019690	ENSCAFP00000048201	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.446
ATF2	PRKD1	ENSCAFP00000019690	ENSCAFP00000058806	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	0.670
ATF3	ATF2	ENSCAFP00000018170	ENSCAFP00000019690	Activating transcription factor 3.	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	0.446
ATF3	ATF4	ENSCAFP00000018170	ENSCAFP00000001900	Activating transcription factor 3.	Activating transcription factor 4.	0.733
ATF3	CDKN1A	ENSCAFP00000018170	ENSCAFP00000050190	Activating transcription factor 3.	Cyclin dependent kinase inhibitor 1A.	0.495
ATF3	EIF2S1	ENSCAFP00000018170	ENSCAFP00000034264	Activating transcription factor 3.	Eukaryotic translation initiation factor 2 subunit alpha.	0.471
ATF4	ATF2	ENSCAFP00000001900	ENSCAFP00000019690	Activating transcription factor 4.	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	0.918
ATF4	ATF3	ENSCAFP00000001900	ENSCAFP00000018170	Activating transcription factor 4.	Activating transcription factor 3.	0.733
ATF4	EIF2AK3	ENSCAFP00000001900	ENSCAFP00000010977	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.951
ATF4	EIF2AK4	ENSCAFP00000001900	ENSCAFP00000012980	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.468
ATF4	EIF2S1	ENSCAFP00000001900	ENSCAFP00000034264	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 subunit alpha.	0.958
ATF4	MAPK1	ENSCAFP00000001900	ENSCAFP00000030998	Activating transcription factor 4.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.903
ATF4	PRKD1	ENSCAFP00000001900	ENSCAFP00000058806	Activating transcription factor 4.	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	0.650
BMT2	C10H12orf66	ENSCAFP00000039384	ENSCAFP00000040219	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Chromosome 10 C12orf66 homolog.	0.843
BMT2	DEPDC5	ENSCAFP00000039384	ENSCAFP00000050074	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain containing 5.	0.845