(78 nodes) Cellular response to reactive oxygen species network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	J9P228_CANLF	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (152 aa)
	LOC100855763	Nudix hydrolase domain-containing protein. (1496 aa)
	AXL	AXL receptor tyrosine kinase. (879 aa)
	UCP1	Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] (442 aa)
	EGFR	Receptor protein-tyrosine kinase. (1141 aa)
	ZNF277	Zinc finger protein 277. (483 aa)
	ANXA1	Annexin. (345 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
	PCGF2	Polycomb group ring finger 2. (344 aa)
	ANKZF1	Ankyrin repeat and zinc finger domain containing 1. (721 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	PRDX5	Redoxin domain-containing protein. (174 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (542 aa)
	SIRT1	Sirtuin 1. (745 aa)
	PRDX3	Thioredoxin domain-containing protein. (278 aa)
	H9GWA7_CANLF	Ion_trans domain-containing protein. (622 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (669 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. (148 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1118 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. (528 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (109 aa)
	LOC100856408	Uncharacterized protein. (206 aa)
	J9P7L3_CANLF	Thioredoxin domain-containing protein. (199 aa)
	SIGMAR1	Sigma non-opioid intracellular receptor 1. (370 aa)
	CCS	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (317 aa)
	ROMO1-2	Reactive oxygen species modulator 1. (79 aa)
	MT3	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
	SOD2	Superoxide dismutase [Mn], mitochondrial. (570 aa)
	IMPACT	Impact RWD domain protein. (421 aa)
	AQP1	Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (373 aa)
	FANCC	FA complementation group C. (749 aa)
	SRC	Tyrosine-protein kinase. (553 aa)
	ENSCAFP00000047060	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (275 aa)
	ROMO1	Reactive oxygen species modulator 1. (79 aa)
	ENSCAFP00000047314	Uncharacterized protein. (153 aa)
	RIPK3	Protein kinase domain-containing protein. (423 aa)
	MAPK3-2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	OSER1	Oxidative stress responsive serine rich 1. (360 aa)
	NQO1	NAD(P)H quinone dehydrogenase 1. (448 aa)
	HDAC6	Histone deacetylase 6. (1186 aa)
	TREX1	Three prime repair exonuclease 1. (373 aa)
	ECT2	Epithelial cell transforming 2. (943 aa)
	ENSCAFP00000051205	Uncharacterized protein. (134 aa)
	PPARGC1B	PPARG coactivator 1 beta. (1028 aa)
	ENSCAFP00000052207	Thioredoxin domain-containing protein. (135 aa)
	ENSCAFP00000056474	1-cysPrx_C domain-containing protein. (96 aa)
	PRDX1	Thioredoxin domain-containing protein. (280 aa)
	RNF112	Ring finger protein 112. (895 aa)
	ENSCAFP00000060413	Uncharacterized protein. (88 aa)
	KDM6B	Lysine demethylase 6B. (1685 aa)
	PARK7	Parkinsonism associated deglycase. (297 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	PTPRK	Protein tyrosine phosphatase receptor type K. (1555 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (441 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (842 aa)
	FXN	Frataxin. (211 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (601 aa)
	PJVK	Pejvakin. (352 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (658 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	SETX	Senataxin. (2700 aa)
	F1PXS7_CANLF	Protein kinase domain-containing protein. (232 aa)
	ZNF580	Zinc finger protein 580. (172 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
	MAPK3	Mitogen-activated protein kinase. (283 aa)
	PDK2	Protein-serine/threonine kinase. (408 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	STK25	Protein kinase domain-containing protein. (426 aa)
	RPS3	40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa)
	NET1	Neuroepithelial cell transforming 1. (658 aa)
	SPHK1	Sphingosine kinase 1. (487 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	EGFR	ENSCAFP00000029535	ENSCAFP00000005164	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.562
ANXA1	EDN1	ENSCAFP00000002591	ENSCAFP00000014389	Annexin.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.434
ANXA1	EGFR	ENSCAFP00000002591	ENSCAFP00000005164	Annexin.	Receptor protein-tyrosine kinase.	0.584
ANXA1	PRDX2	ENSCAFP00000002591	ENSCAFP00000031482	Annexin.	Peroxiredoxin 2.	0.576
AXL	SRC	ENSCAFP00000007520	ENSCAFP00000044994	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.926
CAT	ENSCAFP00000047060	ENSCAFP00000010324	ENSCAFP00000047060	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.400
CAT	ENSCAFP00000052207	ENSCAFP00000010324	ENSCAFP00000052207	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	ENSCAFP00000056474	ENSCAFP00000010324	ENSCAFP00000056474	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	1-cysPrx_C domain-containing protein.	0.570
CAT	J9P228_CANLF	ENSCAFP00000010324	ENSCAFP00000039604	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.878
CAT	J9P7L3_CANLF	ENSCAFP00000010324	ENSCAFP00000041651	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	PARK7	ENSCAFP00000010324	ENSCAFP00000062561	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Parkinsonism associated deglycase.	0.702
CAT	PRDX1	ENSCAFP00000010324	ENSCAFP00000057261	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.572
CAT	PRDX2	ENSCAFP00000010324	ENSCAFP00000031482	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Peroxiredoxin 2.	0.719
CAT	PRDX3	ENSCAFP00000010324	ENSCAFP00000017833	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	PRDX5	ENSCAFP00000010324	ENSCAFP00000021305	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Redoxin domain-containing protein.	0.402
CAT	SOD1	ENSCAFP00000010324	ENSCAFP00000013012	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems.	0.899
CAT	SOD2	ENSCAFP00000010324	ENSCAFP00000043620	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Superoxide dismutase [Mn], mitochondrial.	0.881
CAT	SOD3	ENSCAFP00000010324	ENSCAFP00000064733	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.891
CCS	MT3	ENSCAFP00000042403	ENSCAFP00000042690	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.521
CCS	SOD1	ENSCAFP00000042403	ENSCAFP00000013012	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems.	0.969