(11 nodes) Seh1-associated complex network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (325 aa)
	MIOS	Meiosis regulator for oocyte development. (875 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (380 aa)
	WDR24	WD repeat domain 24. (735 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
	ENSCAFP00000063173	Uncharacterized protein. (97 aa)
	SESN3	Sestrin 3. (573 aa)
	WDR59	WD repeat domain 59. (989 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (744 aa)
	DEPDC5	DEP domain containing 5. (1646 aa)
	SESN1	Sestrin 1. (658 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMT2	DEPDC5	ENSCAFP00000039384	ENSCAFP00000050074	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain containing 5.	0.845
BMT2	ENSCAFP00000063173	ENSCAFP00000039384	ENSCAFP00000063173	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.412
BMT2	NPRL2	ENSCAFP00000039384	ENSCAFP00000015575	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.747
BMT2	NPRL3	ENSCAFP00000039384	ENSCAFP00000049363	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR3 like, GATOR1 complex subunit.	0.693
DEPDC5	BMT2	ENSCAFP00000050074	ENSCAFP00000039384	DEP domain containing 5.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.845
DEPDC5	ENSCAFP00000063173	ENSCAFP00000050074	ENSCAFP00000063173	DEP domain containing 5.	Uncharacterized protein.	0.939
DEPDC5	MIOS	ENSCAFP00000050074	ENSCAFP00000003259	DEP domain containing 5.	Meiosis regulator for oocyte development.	0.998
DEPDC5	NPRL2	ENSCAFP00000050074	ENSCAFP00000015575	DEP domain containing 5.	NPR2 like, GATOR1 complex subunit.	0.999
DEPDC5	NPRL3	ENSCAFP00000050074	ENSCAFP00000049363	DEP domain containing 5.	NPR3 like, GATOR1 complex subunit.	0.996
DEPDC5	SEC13	ENSCAFP00000050074	ENSCAFP00000053904	DEP domain containing 5.	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.991
DEPDC5	SESN1	ENSCAFP00000050074	ENSCAFP00000053155	DEP domain containing 5.	Sestrin 1.	0.812
DEPDC5	SESN3	ENSCAFP00000050074	ENSCAFP00000060938	DEP domain containing 5.	Sestrin 3.	0.583
DEPDC5	WDR24	ENSCAFP00000050074	ENSCAFP00000029025	DEP domain containing 5.	WD repeat domain 24.	0.990
DEPDC5	WDR59	ENSCAFP00000050074	ENSCAFP00000057181	DEP domain containing 5.	WD repeat domain 59.	0.998
ENSCAFP00000063173	BMT2	ENSCAFP00000063173	ENSCAFP00000039384	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.412
ENSCAFP00000063173	DEPDC5	ENSCAFP00000063173	ENSCAFP00000050074	Uncharacterized protein.	DEP domain containing 5.	0.939
ENSCAFP00000063173	MIOS	ENSCAFP00000063173	ENSCAFP00000003259	Uncharacterized protein.	Meiosis regulator for oocyte development.	0.883
ENSCAFP00000063173	NPRL2	ENSCAFP00000063173	ENSCAFP00000015575	Uncharacterized protein.	NPR2 like, GATOR1 complex subunit.	0.939
ENSCAFP00000063173	SEC13	ENSCAFP00000063173	ENSCAFP00000053904	Uncharacterized protein.	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.744
ENSCAFP00000063173	WDR24	ENSCAFP00000063173	ENSCAFP00000029025	Uncharacterized protein.	WD repeat domain 24.	0.908