(16 nodes) Pattern recognition receptor activity network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOD1	Nucleotide binding oligomerization domain containing 1. (964 aa)
	NLRP6	NLR family pyrin domain containing 6. (911 aa)
	NOD2	Uncharacterized protein. (1013 aa)
	CLEC4E	C-type lectin domain family 4 member E. (226 aa)
	TLR9-2	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
	TNFAIP8L2	TNF alpha induced protein 8 like 2. (184 aa)
	PTAFR	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa)
	PGLYRP1	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
	PGLYRP2	Peptidoglycan recognition protein 2. (499 aa)
	FCN1	Ficolin 1. (322 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	COLEC12	Collectin subfamily member 12. (745 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
	CLEC1A	C-type lectin domain containing 7A. (283 aa)
	CLEC4D	C-type lectin domain family 4 member D. (263 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (552 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLEC1A	CLEC4D	ENSCAFP00000045947	ENSCAFP00000046211	C-type lectin domain containing 7A.	C-type lectin domain family 4 member D.	0.583
CLEC1A	NOD2	ENSCAFP00000045947	ENSCAFP00000014425	C-type lectin domain containing 7A.	Uncharacterized protein.	0.557
CLEC1A	TLR7	ENSCAFP00000045947	ENSCAFP00000043898	C-type lectin domain containing 7A.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.498
CLEC1A	TLR9-2	ENSCAFP00000045947	ENSCAFP00000030804	C-type lectin domain containing 7A.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.522
CLEC4D	CLEC1A	ENSCAFP00000046211	ENSCAFP00000045947	C-type lectin domain family 4 member D.	C-type lectin domain containing 7A.	0.583
CLEC4D	CLEC4E	ENSCAFP00000046211	ENSCAFP00000020525	C-type lectin domain family 4 member D.	C-type lectin domain family 4 member E.	0.981
CLEC4E	CLEC4D	ENSCAFP00000020525	ENSCAFP00000046211	C-type lectin domain family 4 member E.	C-type lectin domain family 4 member D.	0.981
CLEC4E	FCN1	ENSCAFP00000020525	ENSCAFP00000041594	C-type lectin domain family 4 member E.	Ficolin 1.	0.431
FCN1	CLEC4E	ENSCAFP00000041594	ENSCAFP00000020525	Ficolin 1.	C-type lectin domain family 4 member E.	0.431
LY96	NOD1	ENSCAFP00000042952	ENSCAFP00000004572	Lymphocyte antigen 96.	Nucleotide binding oligomerization domain containing 1.	0.479
LY96	NOD2	ENSCAFP00000042952	ENSCAFP00000014425	Lymphocyte antigen 96.	Uncharacterized protein.	0.492
LY96	TLR7	ENSCAFP00000042952	ENSCAFP00000043898	Lymphocyte antigen 96.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.747
LY96	TLR9-2	ENSCAFP00000042952	ENSCAFP00000030804	Lymphocyte antigen 96.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.723
NOD1	LY96	ENSCAFP00000004572	ENSCAFP00000042952	Nucleotide binding oligomerization domain containing 1.	Lymphocyte antigen 96.	0.479
NOD1	NOD2	ENSCAFP00000004572	ENSCAFP00000014425	Nucleotide binding oligomerization domain containing 1.	Uncharacterized protein.	0.926
NOD1	TLR7	ENSCAFP00000004572	ENSCAFP00000043898	Nucleotide binding oligomerization domain containing 1.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.592
NOD1	TLR9-2	ENSCAFP00000004572	ENSCAFP00000030804	Nucleotide binding oligomerization domain containing 1.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.515
NOD2	CLEC1A	ENSCAFP00000014425	ENSCAFP00000045947	Uncharacterized protein.	C-type lectin domain containing 7A.	0.557
NOD2	LY96	ENSCAFP00000014425	ENSCAFP00000042952	Uncharacterized protein.	Lymphocyte antigen 96.	0.492
NOD2	NOD1	ENSCAFP00000014425	ENSCAFP00000004572	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 1.	0.926