STRINGSTRING
ADGRF5 ADGRF5 GAMT GAMT C1QA C1QA IFI35 IFI35 PLCG2 PLCG2 PLA2G10 PLA2G10 IFNGR1 IFNGR1 IFNG IFNG TNF TNF IL13 IL13 IL4 IL4 NMI NMI CRTC3 CRTC3 STK39 STK39 AGER AGER PLA2G3 PLA2G3 AOC3 AOC3 L3HYPDH L3HYPDH HAVCR1 HAVCR1 FOXP1 FOXP1 DYSF DYSF SYK SYK JMJD6 JMJD6 TREM2 TREM2 TREX1 TREX1 PRKCE PRKCE CX3CR1 CX3CR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1388 aa)
GAMTStrawberry notch homolog 2. (1458 aa)
C1QAComplement C1q A chain. (264 aa)
IFI35Interferon induced protein 35. (286 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
PLA2G10Phospholipase A(2). (153 aa)
IFNGR1Interferon gamma receptor 1. (475 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
NMIN-myc and STAT interactor. (308 aa)
CRTC3CREB regulated transcription coactivator 3. (594 aa)
STK39Serine/threonine kinase 39. (555 aa)
AGERAdvanced glycosylation end product-specific receptor variant C. (396 aa)
PLA2G3Phospholipase A2 group III. (512 aa)
AOC3Amine oxidase copper containing 3. (1236 aa)
L3HYPDHTrans-L-3-hydroxyproline dehydratase. (359 aa)
HAVCR1Ig-like domain-containing protein. (304 aa)
FOXP1Forkhead box P1. (693 aa)
DYSFDysferlin. (2122 aa)
SYKTyrosine-protein kinase. (699 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (525 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (523 aa)
TREX1Three prime repair exonuclease 1. (373 aa)
PRKCEProtein kinase C. (750 aa)
CX3CR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (384 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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