STRINGSTRING
SESN3 SESN3 SZT2 SZT2 TP53 TP53 KAT5 KAT5 ATF4 ATF4 PICK1 PICK1 PLIN2 PLIN2 ASNS ASNS FOXO3 FOXO3 KPTN KPTN PRKAG2 PRKAG2 PRKAG3 PRKAG3 RRP8 RRP8 EIF2AK3 EIF2AK3 PRKAG1 PRKAG1 NUAK2 NUAK2 XBP1 XBP1 MTMR3 MTMR3 TBL2 TBL2 SIRT1 SIRT1 SIK2 SIK2 ATG14 ATG14 BHLHA15 BHLHA15 PIK3C3 PIK3C3 NIM1K NIM1K PLIN3 PLIN3 PRKAA2 PRKAA2 HSPA5 HSPA5 PMAIP1 PMAIP1 NFE2L2 NFE2L2 MYBBP1A MYBBP1A ITFG2 ITFG2 C10H12orf66 C10H12orf66 NUAK1 NUAK1 SESN2 SESN2 IMPACT IMPACT ZC3H12A ZC3H12A ENSCAFP00000046317 ENSCAFP00000046317 ENSCAFP00000046870 ENSCAFP00000046870 BECN1 BECN1 PRKAA1 PRKAA1 SIK1 SIK1 SESN1 SESN1 SH3GLB1 SH3GLB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SESN3Sestrin 3. (573 aa)
SZT2SZT2 subunit of KICSTOR complex. (3464 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa)
ATF4Activating transcription factor 4. (350 aa)
PICK1Protein interacting with PRKCA 1. (417 aa)
PLIN2Perilipin; Belongs to the perilipin family. (447 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
FOXO3Forkhead box O3. (671 aa)
KPTNKaptin, actin binding protein. (539 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (597 aa)
RRP8Ribosomal RNA processing 8. (664 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1113 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
NUAK2NUAK family kinase 2. (668 aa)
XBP1BZIP domain-containing protein. (380 aa)
MTMR3Myotubularin related protein 3. (1062 aa)
TBL2Transducin beta like 2. (446 aa)
SIRT1Sirtuin 1. (745 aa)
SIK2Salt inducible kinase 2. (918 aa)
ATG14Autophagy related 14. (510 aa)
BHLHA15Basic helix-loop-helix family member a15. (187 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
NIM1KNIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
PLIN3Perilipin; Belongs to the perilipin family. (401 aa)
PRKAA2Non-specific serine/threonine protein kinase. (532 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. (54 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (601 aa)
MYBBP1AMYB binding protein 1a. (1369 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (487 aa)
C10H12orf66Chromosome 10 C12orf66 homolog. (445 aa)
NUAK1NUAK family kinase 1. (666 aa)
SESN2Sestrin 2. (485 aa)
IMPACTImpact RWD domain protein. (421 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (605 aa)
ENSCAFP00000046317Uncharacterized protein. (78 aa)
ENSCAFP00000046870CBS domain-containing protein. (112 aa)
BECN1Beclin 1. (471 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
SIK1Uncharacterized protein. (1388 aa)
SESN1Sestrin 1. (658 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (369 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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