STRINGSTRING
TPR TPR PIK3R2 PIK3R2 EFCAB7 EFCAB7 RBM22 RBM22 TARDBP TARDBP JUP JUP ECT2 ECT2 PRKD1 PRKD1 SMO SMO FLNA FLNA HDAC3 HDAC3 PTPN22 PTPN22 ZC3H12A ZC3H12A ENSCAFP00000048491 ENSCAFP00000048491 IFNG IFNG UBR5 UBR5 GLI3 GLI3 DMAP1 DMAP1 B9D2 B9D2 IPO5 IPO5 PIK3R1 PIK3R1 PTPN5 PTPN5 HCLS1 HCLS1 BAG3 BAG3 ZPR1 ZPR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPRTranslocated promoter region, nuclear basket protein. (2361 aa)
PIK3R2Uncharacterized protein. (726 aa)
EFCAB7EF-hand calcium binding domain 7. (680 aa)
RBM22RNA binding motif protein 22. (420 aa)
TARDBPTAR DNA binding protein. (607 aa)
JUPUncharacterized protein. (744 aa)
ECT2Epithelial cell transforming 2. (943 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (869 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (760 aa)
FLNAFilamin A. (2646 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (815 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (605 aa)
ENSCAFP00000048491RRM domain-containing protein. (292 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
GLI3GLI family zinc finger 3. (1590 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (468 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
IPO5Importin 5. (1083 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (555 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (487 aa)
BAG3BCL2 associated athanogene 3. (579 aa)
ZPR1ZPR1 zinc finger. (460 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (18%) [HD]