STRINGSTRING
IL13 IL13 IL4 IL4 SPHK2 SPHK2 VAMP8 VAMP8 FGR FGR SNX4 SNX4 PLA2G3 PLA2G3 VAMP7 VAMP7 SYK SYK ENSCAFP00000055760 ENSCAFP00000055760
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
SPHK2Sphingosine kinase 2. (733 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
FGRTyrosine-protein kinase. (526 aa)
SNX4Sorting nexin 4. (433 aa)
PLA2G3Phospholipase A2 group III. (512 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (250 aa)
SYKTyrosine-protein kinase. (699 aa)
ENSCAFP00000055760V-SNARE coiled-coil homology domain-containing protein. (107 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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