STRINGSTRING
TLR6 TLR6 MTOR MTOR SYT11 SYT11 RAB8B RAB8B STX10 STX10 TLR9-2 TLR9-2 TLR1 TLR1 RAB11A RAB11A STX8 STX8 DNM2 DNM2 PIK3C3 PIK3C3 RAB38 RAB38 RAB10 RAB10 VAMP7 VAMP7 ENSCAFP00000052292 ENSCAFP00000052292 RAB9B RAB9B OCRL OCRL SLAMF1 SLAMF1 CTSS CTSS STX12 STX12 RAB9A RAB9A SNX3 SNX3 AMBRA1 AMBRA1 TCIRG1 TCIRG1 NOD2 NOD2 PIP4P2 PIP4P2 RAB39A RAB39A ABCA1 ABCA1 CORO1A CORO1A SYK SYK RAB34 RAB34 DLA88 DLA88 RAB11FIP1 RAB11FIP1 APPL2 APPL2 TRIM14 TRIM14 STXBP4 STXBP4 VPS26B VPS26B RAB32 RAB32 LAMP2 LAMP2 RAB7A RAB7A TLR7 TLR7 CLCN3 CLCN3 RAB11FIP5 RAB11FIP5 NOD1 NOD1 INPP5B INPP5B ZYX ZYX ANXA3 ANXA3 ADAM8 ADAM8 RAB14 RAB14 GSN GSN LOC491698 LOC491698 RAB22A RAB22A VAMP3 VAMP3 BECN1 BECN1 ENSCAFP00000055724 ENSCAFP00000055724 ENSCAFP00000056747 ENSCAFP00000056747 RAB23 RAB23 STX6 STX6 KIF5B KIF5B RAB11B RAB11B MYO1C MYO1C STXBP3 STXBP3 CDC42EP2 CDC42EP2 TLR2 TLR2 APPL1 APPL1 RAB7B RAB7B WAS WAS DLA-79 DLA-79 RAB36 RAB36 CLEC4E CLEC4E ATG14 ATG14 ZDHHC5 ZDHHC5 LAMP1 LAMP1 RAB20 RAB20 RAB8A RAB8A RAB5A RAB5A FAM104A FAM104A PLA2G5 PLA2G5 ENSCAFP00000047935 ENSCAFP00000047935 ENSCAFP00000048204 ENSCAFP00000048204 ANXA11 ANXA11 RAB31 RAB31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (797 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
SYT11Synaptotagmin 11. (431 aa)
RAB8BRAB8B, member RAS oncogene family. (178 aa)
STX10Syntaxin 10; Belongs to the syntaxin family. (249 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (760 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa)
STX8Syntaxin 8. (236 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
RAB38RAB38, member RAS oncogene family. (429 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (200 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (250 aa)
ENSCAFP00000052292PX domain-containing protein. (120 aa)
RAB9BRAB9B, member RAS oncogene family. (228 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (881 aa)
SLAMF1Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those [...] (342 aa)
CTSSCathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). (339 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (274 aa)
RAB9ARas-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Belongs to the small GTPase superfamily. Rab family. (201 aa)
SNX3Sorting nexin 3. (174 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
NOD2Uncharacterized protein. (1013 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (227 aa)
RAB39ARAB39A, member RAS oncogene family. (215 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (470 aa)
SYKTyrosine-protein kinase. (699 aa)
RAB34RAB34, member RAS oncogene family. (335 aa)
DLA88DLA class I histocompatibility antigen, A9/A9 alpha chain; Involved in the presentation of foreign antigens to the immune system. (361 aa)
RAB11FIP1RAB11 family interacting protein 1. (1273 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (653 aa)
TRIM14Tripartite motif containing 14. (445 aa)
STXBP4Syntaxin binding protein 4. (557 aa)
VPS26BVPS26, retromer complex component B. (308 aa)
RAB32RAB32, member RAS oncogene family. (205 aa)
LAMP2Lysosomal associated membrane protein 2. (428 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (228 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
CLCN3Chloride channel protein. (865 aa)
RAB11FIP5RAB11 family interacting protein 5. (1307 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (964 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (750 aa)
ZYXZyxin. (411 aa)
ANXA3Annexin. (451 aa)
ADAM8ADAM metallopeptidase domain 8. (807 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
GSNGelsolin. (734 aa)
LOC491698TIR domain-containing protein. (409 aa)
RAB22ARas-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form. (195 aa)
VAMP3Vesicle associated membrane protein 3. (145 aa)
BECN1Beclin 1. (471 aa)
ENSCAFP00000055724PX domain-containing protein. (127 aa)
ENSCAFP00000056747Ig-like domain-containing protein. (183 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
STX6Syntaxin 6; Belongs to the syntaxin family. (299 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (621 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (214 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
RAB7BRAB7B, member RAS oncogene family. (222 aa)
WASWASP actin nucleation promoting factor. (554 aa)
DLA-79Ig-like domain-containing protein; Belongs to the MHC class I family. (504 aa)
RAB36RAB36, member RAS oncogene family. (332 aa)
CLEC4EC-type lectin domain family 4 member E. (226 aa)
ATG14Autophagy related 14. (510 aa)
ZDHHC5Palmitoyltransferase ZDHHC5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5 and for FLOT2; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. (715 aa)
LAMP1Lysosomal associated membrane protein 1. (413 aa)
RAB20RAB20, member RAS oncogene family. (235 aa)
RAB8ARas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
FAM104AFamily with sequence similarity 104 member A. (352 aa)
PLA2G5Phospholipase A(2). (308 aa)
ENSCAFP00000047935IF rod domain-containing protein; Belongs to the intermediate filament family. (415 aa)
ENSCAFP00000048204Uncharacterized protein. (139 aa)
ANXA11Annexin. (713 aa)
RAB31RAB31, member RAS oncogene family. (224 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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