(27 nodes) Myoblast differentiation network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK12	Mitogen-activated protein kinase. (366 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1011 aa)
	LOC100682666	Uncharacterized protein. (315 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (317 aa)
	MEGF10	Multiple EGF like domains 10. (1147 aa)
	RB1	RB transcriptional corepressor 1. (927 aa)
	BCL9L	BCL9 like. (1481 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1098 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (820 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (230 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	TBX2	T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). (655 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	MYOCD	Myocardin. (983 aa)
	SOX15	SRY-box 15. (233 aa)
	PLEKHM3	Pleckstrin homology domain containing M3. (757 aa)
	HINFP	Histone H4 transcription factor. (519 aa)
	BCL9	BCL9 transcription coactivator. (1426 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	TCF7L2	Transcription factor 7 like 2. (565 aa)
	LGALS1	Galectin. (196 aa)
	J9P859_CANLF	Galectin. (135 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	EPAS1	Endothelial PAS domain protein 1. (868 aa)
	REST	RE1 silencing transcription factor. (996 aa)
	SRF	Serum response factor. (508 aa)
	PITX1	Homeobox protein. (313 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL9	BCL9L	ENSCAFP00000016276	ENSCAFP00000054160	BCL9 transcription coactivator.	BCL9 like.	0.592
BCL9	TCF7L2	ENSCAFP00000016276	ENSCAFP00000039879	BCL9 transcription coactivator.	Transcription factor 7 like 2.	0.866
BCL9L	BCL9	ENSCAFP00000054160	ENSCAFP00000016276	BCL9 like.	BCL9 transcription coactivator.	0.592
BCL9L	SDC1	ENSCAFP00000054160	ENSCAFP00000059447	BCL9 like.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.412
BCL9L	TCF7L2	ENSCAFP00000054160	ENSCAFP00000039879	BCL9 like.	Transcription factor 7 like 2.	0.532
FGF6	ITGB1	ENSCAFP00000044738	ENSCAFP00000005722	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Integrin beta; Belongs to the integrin beta chain family.	0.450
FGF6	MYOD1	ENSCAFP00000044738	ENSCAFP00000013332	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.436
ITGB1	FGF6	ENSCAFP00000005722	ENSCAFP00000044738	Integrin beta; Belongs to the integrin beta chain family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.450
ITGB1	SDC1	ENSCAFP00000005722	ENSCAFP00000059447	Integrin beta; Belongs to the integrin beta chain family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.655
LOC100682666	REST	ENSCAFP00000061556	ENSCAFP00000003276	Uncharacterized protein.	RE1 silencing transcription factor.	0.900
MAML1	MAML3	ENSCAFP00000000502	ENSCAFP00000005512	Mastermind like transcriptional coactivator 1.	Mastermind like transcriptional coactivator 3.	0.900
MAML1	NOTCH1	ENSCAFP00000000502	ENSCAFP00000029073	Mastermind like transcriptional coactivator 1.	Notch receptor 1.	0.996
MAML3	MAML1	ENSCAFP00000005512	ENSCAFP00000000502	Mastermind like transcriptional coactivator 3.	Mastermind like transcriptional coactivator 1.	0.900
MAML3	NOTCH1	ENSCAFP00000005512	ENSCAFP00000029073	Mastermind like transcriptional coactivator 3.	Notch receptor 1.	0.987
MAPK12	MYOD1	ENSCAFP00000000978	ENSCAFP00000013332	Mitogen-activated protein kinase.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.524
MYOCD	SRF	ENSCAFP00000026366	ENSCAFP00000002675	Myocardin.	Serum response factor.	0.976
MYOD1	FGF6	ENSCAFP00000013332	ENSCAFP00000044738	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.436
MYOD1	MAPK12	ENSCAFP00000013332	ENSCAFP00000000978	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Mitogen-activated protein kinase.	0.524
MYOD1	PITX1	ENSCAFP00000013332	ENSCAFP00000001499	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Homeobox protein.	0.419
MYOD1	SRF	ENSCAFP00000013332	ENSCAFP00000002675	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Serum response factor.	0.634