STRINGSTRING
MALT1 MALT1 IL23A IL23A IFNG IFNG HLA-DQB1 HLA-DQB1 IL4 IL4 DLA-DOA DLA-DOA ANXA1 ANXA1 CCL19 CCL19 E2R735_CANLF E2R735_CANLF SOCS5 SOCS5 IL4I1 IL4I1 GLI3 GLI3 FOXO3 FOXO3 LOC100687459 LOC100687459 GATA3 GATA3 NCKAP1L NCKAP1L SOX12 SOX12 IL36B IL36B IL7 IL7 RASGRP1 RASGRP1 WNT10B WNT10B RIPK2 RIPK2 EGR3 EGR3 HLX HLX XBP1 XBP1 SART1 SART1 ZBTB16 ZBTB16 DUSP10 DUSP10 BCL6 BCL6 VSIR VSIR CD27 CD27 STAT5B STAT5B RHOH RHOH FOXP3 FOXP3 ITPKB ITPKB ZBTB7B ZBTB7B PIK3R6 PIK3R6 SOCS1 SOCS1 PRKCZ PRKCZ CBFB CBFB BAD BAD SHB SHB SASH3 SASH3 IL2RG IL2RG TNFSF9 TNFSF9 ZBTB1 ZBTB1 CD74 CD74 PCK1 PCK1 ADAM8 ADAM8 ZAP70 ZAP70 NXPE3 NXPE3 SOX13 SOX13 SHH SHH PTPRC PTPRC SYK SYK LEF1 LEF1 CD83 CD83 MYB MYB AMBRA1 AMBRA1 ADA ADA KAT5 KAT5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MALT1MALT1 paracaspase. (758 aa)
IL23AInterleukin 23 subunit alpha. (193 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
DLA-DOAMHC class II antigen DO alpha; Belongs to the MHC class II family. (250 aa)
ANXA1Annexin. (345 aa)
CCL19C-C motif chemokine. (115 aa)
E2R735_CANLFAmino_oxidase domain-containing protein. (477 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
IL4I1Interleukin 4 induced 1. (579 aa)
GLI3GLI family zinc finger 3. (1590 aa)
FOXO3Forkhead box O3. (671 aa)
LOC100687459AIG1-type G domain-containing protein. (341 aa)
GATA3GATA binding protein 3. (444 aa)
NCKAP1LNCK associated protein 1 like. (1133 aa)
SOX12Transcription factor SOX. (321 aa)
IL36BInterleukin-1. (164 aa)
IL7Interleukin 7. (155 aa)
RASGRP1RAS guanyl releasing protein 1. (758 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
EGR3Early growth response 3. (387 aa)
HLXH2.0 like homeobox. (448 aa)
XBP1BZIP domain-containing protein. (380 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (784 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
VSIRV-set immunoregulatory receptor. (423 aa)
CD27CD27 molecule. (229 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
RHOHRas homolog family member H. (191 aa)
FOXP3Forkhead box P3. (452 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (936 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (685 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
SOCS1Suppressor of cytokine signaling 1. (197 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
CBFBCore-binding factor subunit beta. (82 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SHBSH2 domain containing adaptor protein B. (508 aa)
SASH3SAM and SH3 domain containing 3. (381 aa)
IL2RGCytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (254 aa)
ZBTB1Zinc finger/BTB domain-containing protein 1 isoform 1. (712 aa)
CD74CD74 molecule. (272 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (665 aa)
ADAM8ADAM metallopeptidase domain 8. (807 aa)
ZAP70Tyrosine-protein kinase. (592 aa)
NXPE3NFKB inhibitor zeta. (1002 aa)
SOX13SRY-box 13. (618 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (593 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1385 aa)
SYKTyrosine-protein kinase. (699 aa)
LEF1Lymphoid enhancer binding factor 1. (481 aa)
CD83CD83 molecule. (229 aa)
MYBMYB proto-oncogene, transcription factor. (799 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
ADAAdenosine deaminase. (402 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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