STRINGSTRING
IL23A IL23A IFNG IFNG TNF TNF KLF10 KLF10 TNFRSF11B TNFRSF11B IL4 IL4 LRRC17 LRRC17 TNFSF11 TNFSF11 TMEM178A TMEM178A TRAF6 TRAF6 PIK3R1 PIK3R1 POU4F2 POU4F2 FBXW7 FBXW7 NOTCH2 NOTCH2 PPP3CA PPP3CA SLC9B2 SLC9B2 GPR137B GPR137B TCTA TCTA UBASH3B UBASH3B CREB1 CREB1 LTF LTF GPR137 GPR137 FBN1 FBN1 TFE3 TFE3 PRXL2A PRXL2A MTOR MTOR FBXW9 FBXW9 GPR68 GPR68 FSTL3 FSTL3 TOB2 TOB2 OCSTAMP OCSTAMP NF1 NF1 CEBPB CEBPB SFRP1 SFRP1 IAPP IAPP NEDD9 NEDD9 IL17A IL17A GPR55 GPR55 MITF MITF TNFAIP6 TNFAIP6 TREM2 TREM2 PPARGC1B PPARGC1B TMEM64 TMEM64 PIAS3 PIAS3 INPP5D INPP5D FSHR FSHR RASSF2 RASSF2 CSF1 CSF1 CCL3 CCL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL23AInterleukin 23 subunit alpha. (193 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
KLF10Kruppel like factor 10. (479 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
LRRC17Leucine rich repeat containing 17. (463 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (512 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
POU4F2POU domain protein. (408 aa)
FBXW7F-box and WD repeat domain containing 7. (754 aa)
NOTCH2Notch receptor 2. (2726 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
GPR137BG protein-coupled receptor 137B. (398 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (105 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (637 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LTFUncharacterized protein; Belongs to the transferrin family. (708 aa)
GPR137G protein-coupled receptor 137. (396 aa)
FBN1Uncharacterized protein. (2871 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (571 aa)
PRXL2APeroxiredoxin like 2A. (489 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (360 aa)
FSTL3Follistatin like 3. (264 aa)
TOB2Transducer of ERBB2, 2. (336 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (484 aa)
NF1Neurofibromin 1. (2784 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
SFRP1Secreted frizzled related protein 1. (458 aa)
IAPPIslet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. (89 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (868 aa)
IL17AInterleukin 17A. (156 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (338 aa)
MITFMelanocyte inducing transcription factor. (533 aa)
TNFAIP6TNF alpha induced protein 6. (296 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (523 aa)
PPARGC1BPPARG coactivator 1 beta. (1028 aa)
TMEM64Transmembrane protein 64. (262 aa)
PIAS3Protein inhibitor of activated STAT 3. (849 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (704 aa)
RASSF2Ras association domain family member 2. (326 aa)
CSF1Colony stimulating factor 1. (587 aa)
CCL3C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (159 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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