STRINGSTRING
ALDH5A1 ALDH5A1 IDO1 IDO1 MAT1A MAT1A ACAA1 ACAA1 DECR2 DECR2 ETFA ETFA DAO DAO SHMT2 SHMT2 GLS2 GLS2 PHYH PHYH AMDHD2 AMDHD2 ABCD1 ABCD1 PCK1 PCK1 ECHDC2 ECHDC2 LOC608697 LOC608697 GCDH GCDH CPT1B CPT1B HADH HADH ACAD8 ACAD8 ENSCAFP00000048786 ENSCAFP00000048786 HPD HPD LDHD LDHD GLDC GLDC PCCB PCCB ACOXL ACOXL ENSCAFP00000052281 ENSCAFP00000052281 HAL HAL AGXT2 AGXT2 PPARD PPARD ACOX1 ACOX1 ABAT ABAT GNPDA1 GNPDA1 SDSL SDSL GNPDA2 GNPDA2 LOC483960 LOC483960 DECR1 DECR1 ETFB ETFB ALDH1L2 ALDH1L2 ALDH1L1 ALDH1L1 HSD17B4 HSD17B4 ENSCAFP00000055739 ENSCAFP00000055739 HMGCLL1 HMGCLL1 BGLAP BGLAP PON1 PON1 ARG2 ARG2 LOC100855679 LOC100855679 AKR1A1 AKR1A1 ABHD1 ABHD1 AUH AUH ACAA2 ACAA2 ENSCAFP00000057890 ENSCAFP00000057890 AADACL4 AADACL4 HGD HGD LOC477562 LOC477562 LOC477365 LOC477365 ABCD4 ABCD4 QDPR QDPR IDNK IDNK ENSCAFP00000061067 ENSCAFP00000061067 NOS3 NOS3 ECHDC1 ECHDC1 ACADVL ACADVL ASRGL1 ASRGL1 KMO KMO HDC HDC SLC27A2 SLC27A2 LOC491550 LOC491550 ACOX3 ACOX3 PEX5 PEX5 OTC OTC FAH FAH ACADL ACADL ECHS1 ECHS1 EHHADH EHHADH NPL NPL HMGCL HMGCL LOC607355 LOC607355 ACADSB ACADSB FTCD FTCD PCK2 PCK2 MCCC1 MCCC1 CYP2W1 CYP2W1 ABHD2 ABHD2 BDH2 BDH2 CPT1A CPT1A MTRR MTRR ABCD2 ABCD2 GLS GLS HIBCH HIBCH GOT1 GOT1 HOGA1 HOGA1 LPIN3 LPIN3 IVD IVD CYP26B1 CYP26B1 TDO2 TDO2 GOT2 GOT2 MCCC2 MCCC2 CYP26A1 CYP26A1 ADHFE1 ADHFE1 PAH PAH ACOX2 ACOX2 PRODH2 PRODH2 SNRPF SNRPF ACAD11 ACAD11 HAO1 HAO1 LGALS4 LGALS4 KYNU KYNU BCKDHA BCKDHA HADHA HADHA FAAH FAAH DDO DDO UROC1 UROC1 LOC100855730 LOC100855730 AASS AASS IL4I1 IL4I1 HIBADH HIBADH BCKDHB BCKDHB E2R735_CANLF E2R735_CANLF HAAO HAAO GCAT GCAT SLC25A17 SLC25A17 ACAT2 ACAT2 DDAH2 DDAH2 ARG1 ARG1 AIG1 AIG1 PEX7 PEX7 ALDH8A1 ALDH8A1 CDO1 CDO1 SMIM24 SMIM24 DPEP1 DPEP1 GCSH GCSH DBT DBT NUDT7 NUDT7 ABCD3 ABCD3 KYAT3 KYAT3 ACADM ACADM ACADS ACADS AMT AMT TAT TAT ADTRP ADTRP C28H10orf62 C28H10orf62 OAT OAT ACAT1 ACAT1 LPIN2 LPIN2 NAGK NAGK ACOT8 ACOT8 QPRT QPRT HADHB HADHB CRAT CRAT SLC27A4 SLC27A4 GAD1 GAD1 ALDH6A1 ALDH6A1 ALDH4A1 ALDH4A1 CBS CBS DDAH1 DDAH1 SCP2 SCP2 ECI1 ECI1 J9P975_CANLF J9P975_CANLF GPT GPT CROT CROT IDO2 IDO2 ENSCAFP00000044304 ENSCAFP00000044304 LOC475367 LOC475367 ACSF3 ACSF3 CPT1C CPT1C ENSCAFP00000045369 ENSCAFP00000045369 ENSCAFP00000045471 ENSCAFP00000045471 LPIN1 LPIN1 DLST DLST SARDH SARDH PODN PODN CPT2 CPT2 BLMH BLMH PIPOX PIPOX NOS2 NOS2 ENOSF1 ENOSF1 SHMT1 SHMT1 ABHD3 ABHD3 GSTZ1 GSTZ1 BCKDK BCKDK AADACL3 AADACL3 HSD17B10 HSD17B10 ACAD10 ACAD10 PON2 PON2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (421 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (428 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (513 aa)
DECR22,4-dienoyl-CoA reductase 2. (487 aa)
ETFAElectron transfer flavoprotein subunit alpha. (375 aa)
DAOD-amino acid oxidase. (376 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (549 aa)
GLS2Glutaminase 2. (603 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (476 aa)
AMDHD2Amidohydro-rel domain-containing protein. (615 aa)
ABCD1ATP binding cassette subfamily D member 1. (774 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (665 aa)
ECHDC2Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (298 aa)
LOC608697Uncharacterized protein. (1039 aa)
GCDHGlutaryl-CoA dehydrogenase. (531 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (808 aa)
HADHHydroxyacyl-CoA dehydrogenase. (393 aa)
ACAD8Acyl-CoA dehydrogenase family member 8. (442 aa)
ENSCAFP00000048786Uncharacterized protein. (336 aa)
HPD4-hydroxyphenylpyruvate dioxygenase; Belongs to the 4HPPD family. (400 aa)
LDHDLactate dehydrogenase D. (498 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1032 aa)
PCCBPropionyl-CoA carboxylase subunit beta. (590 aa)
ACOXLAcyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (683 aa)
ENSCAFP00000052281Uncharacterized protein. (56 aa)
HALHistidine ammonia-lyase; Belongs to the PAL/histidase family. (667 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (541 aa)
PPARDPeroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). (473 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (735 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
GNPDA1Glucosamine-6-phosphate isomerase. (303 aa)
SDSLSerine dehydratase like. (396 aa)
GNPDA2Glucosamine-6-phosphate deaminase 2. (608 aa)
LOC483960Uncharacterized protein. (551 aa)
DECR12,4-dienoyl-CoA reductase 1. (352 aa)
ETFBElectron transfer flavoprotein subunit beta. (464 aa)
ALDH1L2Aldehyde dehydrogenase 1 family member L2; Belongs to the aldehyde dehydrogenase family. (1077 aa)
ALDH1L1Aldehyde dehydrogenase 1 family member L1; Belongs to the aldehyde dehydrogenase family. (560 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (775 aa)
ENSCAFP00000055739BcrAD_BadFG domain-containing protein. (281 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (471 aa)
BGLAPOsteocalcin; Belongs to the mitochondrial carrier (TC 2.A.29) family. (473 aa)
PON1Paraoxonase 3. (625 aa)
ARG2Arginase. (384 aa)
LOC100855679Aminotran_5 domain-containing protein. (537 aa)
AKR1A1Aldo_ket_red domain-containing protein. (325 aa)
ABHD1Abhydrolase domain containing 1. (455 aa)
AUHAU RNA binding methylglutaconyl-CoA hydratase. (344 aa)
ACAA2Thiolase_N domain-containing protein. (271 aa)
ENSCAFP00000057890GCV_T domain-containing protein. (279 aa)
AADACL4Arylacetamide deacetylase like 4. (417 aa)
HGDHomogentisate 1,2-dioxygenase. (462 aa)
LOC477562Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (653 aa)
LOC477365Epimerase domain-containing protein. (442 aa)
ABCD4ATP binding cassette subfamily D member 4. (676 aa)
QDPRQuinoid dihydropteridine reductase. (317 aa)
IDNKIDNK gluconokinase. (354 aa)
ENSCAFP00000061067Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1256 aa)
ECHDC1Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (387 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (677 aa)
ASRGL1Asparaginase like 1. (316 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
HDCHistidine decarboxylase. (663 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
LOC491550Beta_elim_lyase domain-containing protein. (495 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
PEX5Peroxisomal biogenesis factor 5. (677 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
FAHFumarylacetoacetase. (418 aa)
ACADLAcyl-CoA dehydrogenase long chain. (437 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
NPLN-acetylneuraminate pyruvate lyase; Belongs to the DapA family. (320 aa)
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
LOC607355Aminotran_5 domain-containing protein. (463 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (514 aa)
FTCDFormimidoyltransferase cyclodeaminase. (541 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (794 aa)
MCCC1Methylcrotonoyl-CoA carboxylase 1. (725 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (501 aa)
ABHD2Abhydrolase domain containing 2. (425 aa)
BDH2Uncharacterized protein. (245 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (704 aa)
ABCD2ATP binding cassette subfamily D member 2. (742 aa)
GLSGlutaminase. (754 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (382 aa)
GOT1Aspartate aminotransferase. (413 aa)
HOGA14-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa)
LPIN3Lipin 3. (847 aa)
IVDIsovaleryl-CoA dehydrogenase. (426 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
GOT2Aspartate aminotransferase. (430 aa)
MCCC2Methylcrotonoyl-CoA carboxylase 2. (563 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
ADHFE1Alcohol dehydrogenase iron containing 1. (467 aa)
PAHPhenylalanine hydroxylase. (581 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
PRODH2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (460 aa)
SNRPFAmidohydrolase domain containing 1. (451 aa)
ACAD11Acyl-CoA dehydrogenase family member 11. (781 aa)
HAO1Hydroxyacid oxidase 1. (370 aa)
LGALS4Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (352 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (489 aa)
BCKDHA2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (563 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (762 aa)
FAAHFatty acid amide hydrolase. (579 aa)
DDOD-aspartate oxidase. (351 aa)
UROC1Urocanate hydratase 1. (735 aa)
LOC100855730Uncharacterized protein. (359 aa)
AASSAminoadipate-semialdehyde synthase. (920 aa)
IL4I1Interleukin 4 induced 1. (579 aa)
HIBADH3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (336 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (423 aa)
E2R735_CANLFAmino_oxidase domain-containing protein. (477 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase. (259 aa)
GCATGlycine C-acetyltransferase. (430 aa)
SLC25A17Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (393 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (285 aa)
ARG1Arginase. (322 aa)
AIG1Androgen induced 1. (329 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
ALDH8A1Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
CDO1Cysteine dioxygenase. (200 aa)
SMIM24Small integral membrane protein 24. (132 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (446 aa)
GCSHGlycine cleavage system protein H. (306 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
NUDT7Nudix hydrolase 7. (238 aa)
ABCD3ATP binding cassette subfamily D member 3. (650 aa)
KYAT3Kynurenine aminotransferase 3. (455 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (415 aa)
ACADSAcyl-CoA dehydrogenase short chain. (396 aa)
AMTAminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
ADTRPAndrogen dependent TFPI regulating protein. (284 aa)
C28H10orf62Chromosome 28 C10orf62 homolog. (223 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (433 aa)
LPIN2Lipin 2. (941 aa)
NAGKBcrAD_BadFG domain-containing protein. (344 aa)
ACOT8Acyl-CoA thioesterase 8. (377 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa)
HADHBUncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
SLC27A4Solute carrier family 27 member 4. (645 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (595 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (543 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (564 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (549 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (540 aa)
ECI1Enoyl-CoA delta isomerase 1. (243 aa)
J9P975_CANLFAminotran_1_2 domain-containing protein. (251 aa)
GPTGlutamic--pyruvic transaminase. (153 aa)
CROTCarnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (622 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (438 aa)
ENSCAFP00000044304Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (442 aa)
LOC475367Amidase domain-containing protein. (406 aa)
ACSF3Acyl-CoA synthetase family member 3. (660 aa)
CPT1CCarnitine palmitoyltransferase 1C. (914 aa)
ENSCAFP00000045369Uncharacterized protein. (172 aa)
ENSCAFP00000045471Aspartate aminotransferase. (402 aa)
LPIN1Lipin 1. (1014 aa)
DLSTDihydrolipoamide S-succinyltransferase. (652 aa)
SARDHSarcosine dehydrogenase. (943 aa)
PODNPodocan. (598 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (659 aa)
BLMHBleomycin hydrolase; Belongs to the peptidase C1 family. (455 aa)
PIPOXPipecolic acid and sarcosine oxidase. (392 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1157 aa)
ENOSF1Enolase superfamily member 1. (443 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
ABHD3Abhydrolase domain containing 3. (404 aa)
GSTZ1Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (217 aa)
BCKDKProtein-serine/threonine kinase. (528 aa)
AADACL3Arylacetamide deacetylase like 3. (449 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
ACAD10APH domain-containing protein. (654 aa)
PON2Serum paraoxonase/arylesterase 2; Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters; Belongs to the paraoxonase family. (377 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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