(51 nodes) Oligodendrocyte differentiation network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PLP1	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. (320 aa)
	SOX10	SRY-box transcription factor 10. (468 aa)
	GLI3	GLI family zinc finger 3. (1590 aa)
	EIF2B3	Eukaryotic translation initiation factor 2B subunit gamma. (452 aa)
	NKX6-2	NK6 homeobox 2. (309 aa)
	TRPC4	Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
	WASF3	WASP family member 3. (502 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (218 aa)
	EIF2B1	Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (305 aa)
	PRDM8	PR/SET domain 8. (452 aa)
	NKX6-1	NK6 homeobox 1. (366 aa)
	CNTN1	Contactin 1. (1018 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (729 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	ZNF488	Zinc finger protein 488. (401 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
	MED12	Mediator complex subunit 12. (2141 aa)
	EIF2B2	Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (420 aa)
	B4GALT6	Beta-1,4-galactosyltransferase 6. (467 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (739 aa)
	VTN	SMB domain-containing protein. (524 aa)
	ASPA	Aspartoacylase. (313 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	FA2H	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
	EIF2B4	Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (546 aa)
	DLX2	Distal-less homeobox 2. (334 aa)
	MAG	Myelin associated glycoprotein. (601 aa)
	CNTN2	Contactin 2. (1010 aa)
	NF1	Neurofibromin 1. (2784 aa)
	SOX8	SRY-box 8. (462 aa)
	MYRF	Myelin regulatory factor. (1277 aa)
	TPPP	Tubulin polymerization promoting protein. (603 aa)
	PTPRZ1	Protein tyrosine phosphatase receptor type Z1. (1914 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (381 aa)
	OLIG1	Oligodendrocyte transcription factor 1. (278 aa)
	KCNJ10	Potassium voltage-gated channel subfamily J member 10. (414 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase. (453 aa)
	SOX13	SRY-box 13. (618 aa)
	ENSCAFP00000051170	NTP_transferase domain-containing protein. (150 aa)
	ENSCAFP00000053140	Uncharacterized protein. (59 aa)
	B4GALT5	Beta-1,4-galactosyltransferase 5. (440 aa)
	CDK5	Cyclin dependent kinase 5. (390 aa)
	TENM4	Teneurin transmembrane protein 4. (2922 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (764 aa)
	TSPAN2	Tetraspanin. (304 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	NKX2-2	Thyroid transcription factor 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis; Belongs to the NK-2 homeobox family. (333 aa)
	DLX1	Distal-less homeobox 1. (265 aa)
	NCSTN	Ncstrn_small domain-containing protein. (708 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	DLX1	ENSCAFP00000010864	ENSCAFP00000064473	Achaete-scute family bHLH transcription factor 1.	Distal-less homeobox 1.	0.559
ASCL1	DLX2	ENSCAFP00000010864	ENSCAFP00000031627	Achaete-scute family bHLH transcription factor 1.	Distal-less homeobox 2.	0.859
ASCL1	HES5	ENSCAFP00000010864	ENSCAFP00000028708	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 5.	0.565
ASCL1	NKX2-2	ENSCAFP00000010864	ENSCAFP00000063267	Achaete-scute family bHLH transcription factor 1.	Thyroid transcription factor 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis; Belongs to the NK-2 homeobox family.	0.518
ASCL1	OLIG1	ENSCAFP00000010864	ENSCAFP00000041648	Achaete-scute family bHLH transcription factor 1.	Oligodendrocyte transcription factor 1.	0.622
ASCL1	OLIG2	ENSCAFP00000010864	ENSCAFP00000041269	Achaete-scute family bHLH transcription factor 1.	Oligodendrocyte transcription factor 2.	0.823
ASCL1	SOX10	ENSCAFP00000010864	ENSCAFP00000002067	Achaete-scute family bHLH transcription factor 1.	SRY-box transcription factor 10.	0.741
ASPA	CNP	ENSCAFP00000028544	ENSCAFP00000048027	Aspartoacylase.	2',3'-cyclic nucleotide 3' phosphodiesterase.	0.494
ASPA	EIF2B2	ENSCAFP00000028544	ENSCAFP00000025032	Aspartoacylase.	Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family.	0.454
ASPA	OLIG2	ENSCAFP00000028544	ENSCAFP00000041269	Aspartoacylase.	Oligodendrocyte transcription factor 2.	0.641
B4GALT5	B4GALT6	ENSCAFP00000054491	ENSCAFP00000026664	Beta-1,4-galactosyltransferase 5.	Beta-1,4-galactosyltransferase 6.	0.551
B4GALT6	B4GALT5	ENSCAFP00000026664	ENSCAFP00000054491	Beta-1,4-galactosyltransferase 6.	Beta-1,4-galactosyltransferase 5.	0.551
B4GALT6	PLP1	ENSCAFP00000026664	ENSCAFP00000065483	Beta-1,4-galactosyltransferase 6.	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.	0.431
CNP	ASPA	ENSCAFP00000048027	ENSCAFP00000028544	2',3'-cyclic nucleotide 3' phosphodiesterase.	Aspartoacylase.	0.494
CNP	MAG	ENSCAFP00000048027	ENSCAFP00000033164	2',3'-cyclic nucleotide 3' phosphodiesterase.	Myelin associated glycoprotein.	0.886
CNP	MYRF	ENSCAFP00000048027	ENSCAFP00000036850	2',3'-cyclic nucleotide 3' phosphodiesterase.	Myelin regulatory factor.	0.489
CNP	OLIG1	ENSCAFP00000048027	ENSCAFP00000041648	2',3'-cyclic nucleotide 3' phosphodiesterase.	Oligodendrocyte transcription factor 1.	0.661
CNP	OLIG2	ENSCAFP00000048027	ENSCAFP00000041269	2',3'-cyclic nucleotide 3' phosphodiesterase.	Oligodendrocyte transcription factor 2.	0.777
CNP	PLP1	ENSCAFP00000048027	ENSCAFP00000065483	2',3'-cyclic nucleotide 3' phosphodiesterase.	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.	0.788
CNP	SOX10	ENSCAFP00000048027	ENSCAFP00000002067	2',3'-cyclic nucleotide 3' phosphodiesterase.	SRY-box transcription factor 10.	0.520