STRINGSTRING
MEF2A MEF2A BMP2 BMP2 CXADR CXADR ALPK2 ALPK2 NPRL3 NPRL3 TREX1 TREX1 PRMT1 PRMT1 SIK1 SIK1 NEBL NEBL SMAD4 SMAD4 MEF2C MEF2C MYH6 MYH6 ARID2 ARID2 PLN PLN ANKRD1 ANKRD1 MYL10 MYL10 WNT8A WNT8A ENSCAFP00000057500 ENSCAFP00000057500 ADPRHL1 ADPRHL1 ALDH1A2 ALDH1A2 TENM4 TENM4 PKP2 PKP2 KDM6B KDM6B LMNA LMNA ENSCAFP00000063173 ENSCAFP00000063173 SAV1 SAV1 PDGFRA PDGFRA MYL2 MYL2 RARB RARB LRP2 LRP2 FHL2 FHL2 SRF SRF FOXH1 FOXH1 PLEC PLEC CBY1 CBY1 LRRC10 LRRC10 MAML1 MAML1 SLC9A1 SLC9A1 VWA5B2 VWA5B2 XIRP2 XIRP2 MYO18B MYO18B VWA5A VWA5A PRKAR1B PRKAR1B GJA5 GJA5 ADPRH ADPRH ACTN2 ACTN2 TGFB2 TGFB2 TNNI1 TNNI1 RYR2 RYR2 DSP DSP IRX3 IRX3 CSRP3 CSRP3 DLL4 DLL4 TBX5 TBX5 MYBPC3 MYBPC3 GREM1 GREM1 PTCD2 PTCD2 EDNRA EDNRA SMAD1 SMAD1 CHD7 CHD7 SGCG SGCG SGCZ SGCZ CAV3 CAV3 PPP1R13L PPP1R13L NOX4 NOX4 ITGB1 ITGB1 ATG5 ATG5 MAML3 MAML3 MYLK3 MYLK3 BVES BVES BMP10 BMP10 ZMPSTE24 ZMPSTE24 PROX1 PROX1 HEG1 HEG1 GATA5 GATA5 GJC1 GJC1 BMP4 BMP4 HNRNPU HNRNPU BMPR1A BMPR1A MED1 MED1 MTOR MTOR ASB2 ASB2 HAND1 HAND1 MYOCD MYOCD IFT20 IFT20 NDUFV2 NDUFV2 ZIC3 ZIC3 SMAD7 SMAD7 NOTCH1 NOTCH1 TSC1 TSC1 ACADM ACADM LRRC10B LRRC10B TBX20 TBX20 TBX2 TBX2 NRAP NRAP JARID2 JARID2 MYLK2 MYLK2 DIPK2A DIPK2A ALPK3 ALPK3 MYL7 MYL7 TGFBR1 TGFBR1 MESP1 MESP1 NKX2-5 NKX2-5 WNT2 WNT2 ENG ENG TBX3 TBX3 TCAP TCAP ZFPM2 ZFPM2 SGCD SGCD FGF9 FGF9 PTEN PTEN TNNC1 TNNC1 PRKAR1A PRKAR1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEF2AMyocyte enhancer factor 2A. (609 aa)
BMP2Bone morphogenetic protein 2. (436 aa)
CXADRCXADR Ig-like cell adhesion molecule. (381 aa)
ALPK2Alpha kinase 2. (2116 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (744 aa)
TREX1Three prime repair exonuclease 1. (373 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (648 aa)
SIK1Uncharacterized protein. (1388 aa)
NEBLNebulette. (1017 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MYH6Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
ARID2AT-rich interaction domain 2. (1874 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Belongs to the phospholamban family. (52 aa)
ANKRD1Ankyrin repeat domain 1. (340 aa)
MYL10Myosin light chain 10. (187 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
ENSCAFP00000057500Uncharacterized protein. (184 aa)
ADPRHL1Uncharacterized protein. (352 aa)
ALDH1A2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (555 aa)
TENM4Teneurin transmembrane protein 4. (2922 aa)
PKP2Plakophilin 2. (876 aa)
KDM6BLysine demethylase 6B. (1685 aa)
LMNAUncharacterized protein; Belongs to the intermediate filament family. (785 aa)
ENSCAFP00000063173Uncharacterized protein. (97 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa)
MYL2Myosin light chain 2. (175 aa)
RARBRetinoic acid receptor beta. (464 aa)
LRP2LDL receptor related protein 2. (4645 aa)
FHL2Four and a half LIM domains 2. (279 aa)
SRFSerum response factor. (508 aa)
FOXH1Forkhead box H1. (399 aa)
PLECPlectin. (4703 aa)
CBY1Chibby family member 1, beta catenin antagonist. (127 aa)
LRRC10Leucine rich repeat containing 10. (279 aa)
MAML1Mastermind like transcriptional coactivator 1. (1011 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1227 aa)
XIRP2Xin actin binding repeat containing 2. (3291 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2557 aa)
VWA5AVon Willebrand factor A domain containing 5A. (809 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (443 aa)
GJA5Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
ACTN2Actinin alpha 2. (894 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TNNI1Troponin I1, slow skeletal type. (270 aa)
RYR2Ryanodine receptor 2. (4903 aa)
DSPDesmoplakin. (2280 aa)
IRX3Iroquois homeobox 3. (557 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (732 aa)
TBX5T-box transcription factor 5. (519 aa)
MYBPC3Myosin binding protein C, cardiac. (1293 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (230 aa)
PTCD2Pentatricopeptide repeat domain 2. (426 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (426 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
SGCGGamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. (370 aa)
SGCZSarcoglycan zeta. (312 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (209 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (483 aa)
NOX4NADPH oxidase 4. (323 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
MAML3Mastermind like transcriptional coactivator 3. (1098 aa)
MYLK3Myosin light chain kinase 3. (850 aa)
BVESBlood vessel epicardial substance. (360 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PROX1Prospero homeobox 1. (737 aa)
HEG1Heart development protein with EGF like domains 1. (1415 aa)
GATA5GATA binding protein 5. (424 aa)
GJC1Gap junction gamma-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (805 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
MYOCDMyocardin. (983 aa)
IFT20Intraflagellar transport 20. (132 aa)
NDUFV2NADH dehydrogenase [ubiquinone] flavoprotein 2. (249 aa)
ZIC3Zic family member 3. (466 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
NOTCH1Notch receptor 1. (2565 aa)
TSC1TSC complex subunit 1. (1169 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (415 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
TBX20T-box transcription factor 20. (448 aa)
TBX2T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). (655 aa)
NRAPNebulin related anchoring protein. (1728 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1313 aa)
MYLK2Myosin light chain kinase 2. (634 aa)
DIPK2APIP49_C domain-containing protein. (839 aa)
ALPK3Alpha kinase 3. (1616 aa)
MYL7Uncharacterized protein. (203 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (265 aa)
NKX2-5Transcription factor NKX2.5. (322 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ENGEndoglin. (652 aa)
TBX3T-box transcription factor 3. (720 aa)
TCAPTitin-cap. (210 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1193 aa)
SGCDSarcoglycan delta. (334 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (303 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (385 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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