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| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (452 aa) |
| | NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D. (428 aa) |
| | CST7 | Cystatin F. (144 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (336 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (512 aa) |
| | CXCL17 | C-X-C motif chemokine ligand 17. (119 aa) |
| | MYD88 | MYD88 innate immune signal transduction adaptor. (398 aa) |
| | MKRN2 | Makorin ring finger protein 2. (416 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | SPHK1 | Sphingosine kinase 1. (487 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa) |
| | FNDC4 | Fibronectin type III domain containing 4. (229 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa) |
| | ZFP36 | ZFP36 ring finger protein. (335 aa) |
| | NMI | N-myc and STAT interactor. (308 aa) |
| | STING1 | Transmembrane protein 173. (375 aa) |
| | NR1D2 | Nuclear receptor subfamily 1 group D member 2. (576 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (911 aa) |
| | MFHAS1 | Malignant fibrous histiocytoma amplified sequence 1. (1042 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (485 aa) |
| | NLRP10 | NLR family pyrin domain containing 10. (688 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (642 aa) |
| | FFAR2 | Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (331 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (304 aa) |
| | IL20RB | Interleukin 20 receptor subunit beta. (311 aa) |
| | VAMP8 | Vesicle associated membrane protein 8. (101 aa) |
| | FFAR4 | G protein-coupled receptor 120. (361 aa) |
| | PBK | PDZ binding kinase. (324 aa) |
| | SETD6 | SET domain containing 6, protein lysine methyltransferase. (574 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (749 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (447 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (669 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | CD81 | Tetraspanin. (233 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | CD200 | CD200 molecule. (242 aa) |
| | F1PUT0_CANLF | Ig-like domain-containing protein. (293 aa) |
| | F1PUS3_CANLF | Ig-like domain-containing protein. (211 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1065 aa) |
| | RABGEF1 | RAB guanine nucleotide exchange factor 1. (784 aa) |
| | PTGIS | Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (475 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa) |
| | SPATA2 | Spermatogenesis associated 2. (520 aa) |
| | FCGR1A | Uncharacterized protein. (428 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa) |
| | RHBDD3 | Rhomboid domain containing 3. (386 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | OSM | Oncostatin M. (247 aa) |
| | SNX4 | Sorting nexin 4. (433 aa) |
| | PLA2G3 | Phospholipase A2 group III. (512 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (542 aa) |
| | F1PCP9_CANLF | Uncharacterized protein. (121 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | AHSG | Alpha 2-HS glycoprotein. (365 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | ZP3 | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (441 aa) |
| | DUOXA2 | Dual oxidase maturation factor 2. (320 aa) |
| | DUOXA1 | Dual oxidase maturation factor 1. (342 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | ADORA2A | Adenosine receptor A2a; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. (412 aa) |
| | BCL6 | B-cell lymphoma 6 protein. (706 aa) |
| | GRN | Granulin precursor. (580 aa) |
| | LPCAT3 | Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (625 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa) |
| | MMP8 | Matrix metallopeptidase 8. (476 aa) |
| | BST1 | Bone marrow stromal cell antigen 1. (311 aa) |
| | GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (291 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | NLRP1 | NLR family pyrin domain containing 1. (1432 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | DAGLB | Diacylglycerol lipase beta. (671 aa) |
| | FOXP3 | Forkhead box P3. (452 aa) |
| | ALOX12 | Arachidonate 15-lipoxygenase. (664 aa) |
| | BCL6B | BCL6B transcription repressor. (476 aa) |
| | DAGLA | Diacylglycerol lipase alpha. (901 aa) |
| | IL17RA | Interleukin 17 receptor A. (866 aa) |
| | GPS2 | G protein pathway suppressor 2. (327 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (612 aa) |
| | TLR10 | Toll like receptor 10; Belongs to the Toll-like receptor family. (807 aa) |
| | F12 | Coagulation factor XII. (598 aa) |
| | RORA | RAR related orphan receptor A. (528 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | SYT11 | Synaptotagmin 11. (431 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (2965 aa) |
| | AREL1 | Apoptosis resistant E3 ubiquitin protein ligase 1. (793 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | ABCC1 | Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (By similarity). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). [...] (1541 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (611 aa) |
| | SEMA7A | Semaphorin 7A; Belongs to the semaphorin family. (632 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1699 aa) |
| | OSMR | Oncostatin M receptor. (968 aa) |
| | PLA2G10 | Phospholipase A(2). (153 aa) |
| | C1QTNF3 | C1q domain-containing protein. (380 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (408 aa) |
| | GIT1 | GIT ArfGAP 1. (770 aa) |
| | C2CD4C | C2 calcium dependent domain containing 4C. (568 aa) |
| | FANCA | FA complementation group A. (1448 aa) |
| | FOXF1 | Forkhead box F1. (354 aa) |
| | PLCG2 | Phosphoinositide phospholipase C. (1336 aa) |
| | KARS1 | Lysine--tRNA ligase. (625 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | CDH5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (775 aa) |
| | TLR9-2 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (729 aa) |
| | CASP4 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (489 aa) |
| | TNFAIP8L2 | TNF alpha induced protein 8 like 2. (184 aa) |
| | IFI35 | Interferon induced protein 35. (286 aa) |
| | J9JHW4_CANLF | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (263 aa) |
| | TNC | Tenascin C. (2384 aa) |
| | DROSHA | Drosha ribonuclease III. (1398 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | AOAH | Acyloxyacyl hydrolase. (601 aa) |
| | DNASE1L2 | Deoxyribonuclease 1 like 2. (256 aa) |
| | SELENOS | Selenoprotein S. (189 aa) |
| | PDCD4 | Programmed cell death 4. (469 aa) |
| | C1QTNF12 | C1q and TNF related 12. (425 aa) |
| | LOC100855742 | Uncharacterized protein. (1062 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa) |
| | PDE2A | Phosphodiesterase. (918 aa) |
| | LOC100686507 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (172 aa) |
| | AKNA | AT-hook transcription factor. (946 aa) |
| | J9P0P1_CANLF | Ig-like domain-containing protein. (309 aa) |
| | MVK | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (423 aa) |
| | SHPK | Uncharacterized protein. (527 aa) |
| | GPR17 | G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (339 aa) |
| | LOC102152879 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (308 aa) |
| | FANCD2 | FA complementation group D2. (1471 aa) |
| | FUT7 | Fucosyltransferase 7. (342 aa) |
| | J9P3C7_CANLF | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | J9P3Z4_CANLF | Uncharacterized protein. (153 aa) |
| | PTGES | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). (153 aa) |
| | LOC102157101 | NACHT domain-containing protein. (1050 aa) |
| | PIK3AP1 | Phosphoinositide-3-kinase adaptor protein 1. (821 aa) |
| | LGALS1 | Galectin. (196 aa) |
| | IL37 | Interleukin-1. (288 aa) |
| | J9P859_CANLF | Galectin. (135 aa) |
| | NLRP12 | Uncharacterized protein. (1059 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa) |
| | J9P915_CANLF | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (266 aa) |
| | J9P9G4_CANLF | Proteasome subunit alpha type. (263 aa) |
| | CASP12 | Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution. (509 aa) |
| | J9PB83_CANLF | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (120 aa) |
| | LDLR | Low density lipoprotein receptor. (888 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (519 aa) |
| | MAS1 | Mas-related G protein-coupled receptor A; Belongs to the G-protein coupled receptor 1 family. (325 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (318 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (629 aa) |
| | PTGER4 | Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (610 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (807 aa) |
| | LYN | Tyrosine-protein kinase. (566 aa) |
| | S100A9 | EF-hand domain-containing protein; Belongs to the S-100 family. (186 aa) |
| | GPSM3 | G protein signaling modulator 3. (208 aa) |
| | NXPE3 | NFKB inhibitor zeta. (1002 aa) |
| | TREX1 | Three prime repair exonuclease 1. (373 aa) |
| | NLRP14 | NLR family pyrin domain containing 14. (1092 aa) |
| | ENSCAFP00000050490 | Uncharacterized protein. (67 aa) |
| | LACC1 | Uncharacterized protein. (430 aa) |
| | FEM1A | Fem-1 homolog A. (673 aa) |
| | TNFAIP6 | TNF alpha induced protein 6. (296 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (523 aa) |
| | VAMP7 | Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (250 aa) |
| | LRFN5 | Leucine rich repeat and fibronectin type III domain containing 5. (722 aa) |
| | LGALS2 | Galectin. (191 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). (473 aa) |
| | CD28 | CD28 molecule. (246 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (482 aa) |
| | DEFB114 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa) |
| | PPARA | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (568 aa) |
| | DNASE1 | Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G- actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Deg [...] (299 aa) |
| | ENSCAFP00000054811 | Uncharacterized protein. (423 aa) |
| | MGLL | Monoglyceride lipase. (505 aa) |
| | ENSCAFP00000055743 | Uncharacterized protein. (305 aa) |
| | ENSCAFP00000055760 | V-SNARE coiled-coil homology domain-containing protein. (107 aa) |
| | GGT1 | Uncharacterized protein. (678 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (662 aa) |
| | LETMD1 | LETM1 domain containing 1. (425 aa) |
| | TYRO3 | TYRO3 protein tyrosine kinase. (902 aa) |
| | FOXP1 | Forkhead box P1. (693 aa) |
| | RB1 | RB transcriptional corepressor 1. (927 aa) |
| | ENSCAFP00000058760 | Uncharacterized protein. (183 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (972 aa) |
| | GLTP | ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (920 aa) |
| | ENSCAFP00000059957 | Proteasome endopeptidase complex. (243 aa) |
| | SETD4 | SET domain containing 4. (510 aa) |
| | CD47 | CD47 molecule. (439 aa) |
| | LOC484343 | Uncharacterized protein. (750 aa) |
| | AGER | Advanced glycosylation end product-specific receptor variant C. (396 aa) |
| | CCL24 | C-C motif chemokine 24; Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (232 aa) |
| | WFDC1 | WAP four-disulfide core domain 1. (285 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (752 aa) |
| | PARK7 | Parkinsonism associated deglycase. (297 aa) |
| | IDO1 | Indoleamine 2,3-dioxygenase 1. (421 aa) |
| | FABP4 | Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa) |
| | STK39 | Serine/threonine kinase 39. (555 aa) |
| | ADA | Adenosine deaminase. (402 aa) |
| | XKR8 | Sphingomyelin phosphodiesterase acid like 3B. (464 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1262 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (370 aa) |
| | PROC | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (490 aa) |
| | NDFIP1 | Nedd4 family interacting protein 1. (225 aa) |
| | GAMT | Strawberry notch homolog 2. (1458 aa) |
| | PSMA1 | Proteasome subunit alpha type. (267 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa) |
| | UFL1 | UFM1 specific ligase 1. (791 aa) |
| | IRF3 | Interferon regulatory factor 3. (281 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (648 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (231 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa) |
| | LTA | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity). (204 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 2. (303 aa) |
| | GPR31 | G protein-coupled receptor 31; Belongs to the G-protein coupled receptor 1 family. (316 aa) |
| | IL13 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa) |
| | CCN4 | Cellular communication network factor 4. (362 aa) |
| | IL33 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). (263 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (860 aa) |
| | LRRC19 | Leucine rich repeat containing 19. (369 aa) |
| | ANXA1 | Annexin. (345 aa) |
| | TTBK1 | Tau tubulin kinase 1. (818 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (557 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (578 aa) |
| | NINJ1 | Ninjurin 1. (151 aa) |
| | NLRP5 | NLR family pyrin domain containing 5. (1142 aa) |
| | NLRP8 | NLR family pyrin domain containing 8. (1016 aa) |
| | NLRP9 | NLR family pyrin domain containing 9. (988 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (1063 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | NLRP2 | Uncharacterized protein. (162 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (467 aa) |
