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| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | IL23A | Interleukin 23 subunit alpha. (193 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1338 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (228 aa) |
| | FGFR3 | Fibroblast growth factor receptor 3. (978 aa) |
| | AFAP1L2 | Actin filament associated protein 1 like 2. (985 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (354 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1324 aa) |
| | GAS6 | Growth arrest specific 6. (661 aa) |
| | CSF1R | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa) |
| | THBS4 | Thrombospondin 4. (1038 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1385 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | SYK | Tyrosine-protein kinase. (699 aa) |
| | LOC489915 | Uncharacterized protein. (185 aa) |
| | PLPP3 | Phospholipid phosphatase 3. (312 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa) |
| | IL34 | Interleukin 34. (261 aa) |
| | LOC102151982 | Uncharacterized protein. (1585 aa) |
| | ARHGEF2 | Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...] (1194 aa) |
| | ENSCAFP00000057906 | Uncharacterized protein. (60 aa) |
| | BTC | Betacellulin. (187 aa) |
| | LRP8 | LDL receptor related protein 8. (1044 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (752 aa) |
| | ENSCAFP00000062654 | ARL2_Bind_BART domain-containing protein. (91 aa) |
| | NRP1 | Neuropilin 1. (1029 aa) |
| | IL6ST | Uncharacterized protein. (954 aa) |
| | IGF2 | Insulin like growth factor 2. (304 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (718 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa) |
| | KITLG | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins. (335 aa) |
| | FCGR1A | Uncharacterized protein. (428 aa) |
| | IL20 | Interleukin 20. (176 aa) |
| | CD80 | CD80 molecule. (304 aa) |
| | ADRA2A | Adrenoceptor alpha 2A; Belongs to the G-protein coupled receptor 1 family. (411 aa) |
| | GRM5 | Glutamate metabotropic receptor 5. (1238 aa) |
| | LIF | LIF interleukin 6 family cytokine. (202 aa) |
| | CD81 | Tetraspanin. (233 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | ARL2BP | ADP ribosylation factor like GTPase 2 binding protein. (163 aa) |
| | GREM1 | Gremlin 1, DAN family BMP antagonist. (230 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (754 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | IL31RA | Interleukin 31 receptor A. (728 aa) |
| | ANGPT4 | Angiopoietin 4. (498 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (487 aa) |
| | CASS4 | Cas scaffold protein family member 4. (782 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (539 aa) |
| | OSM | Oncostatin M. (247 aa) |
| | GH1 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa) |
| | SH2D1B | SH2 domain containing 1B. (153 aa) |
| | TNFSF18 | TNF superfamily member 18. (190 aa) |
| | DOK7 | Docking protein 7. (479 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa) |
| | BMP6 | Bone morphogenetic protein 6. (335 aa) |
| | EREG | Epiregulin. (160 aa) |
| | AREG | Amphiregulin. (275 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (868 aa) |
| | J9P7J3_CANLF | Uncharacterized protein. (572 aa) |
| | LRP4 | LDL receptor related protein 4. (1953 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (495 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (580 aa) |
| | ENSCAFP00000043591 | Uncharacterized protein. (176 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (318 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | CD74 | CD74 molecule. (272 aa) |
| | SRCIN1 | SRC kinase signaling inhibitor 1. (1587 aa) |
| | LYN | Tyrosine-protein kinase. (566 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (1008 aa) |
| | DGKQ | Diacylglycerol kinase. (1018 aa) |
| | ENSCAFP00000047559 | ARL2_Bind_BART domain-containing protein. (116 aa) |
| | CRLF1 | Cytokine receptor like factor 1. (383 aa) |
| | FGF7 | Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). (194 aa) |
| | GATA1 | GATA binding protein 1. (412 aa) |
| | EPHA4 | EPH receptor A4. (955 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa) |
| | CTF1 | Uncharacterized protein. (201 aa) |
| | EFNA1 | Ephrin A1; Belongs to the ephrin family. (205 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | HAX1 | HCLS1 associated protein X-1. (288 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | CSPG4 | Chondroitin sulfate proteoglycan 4. (2439 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1699 aa) |
| | VTN | SMB domain-containing protein. (524 aa) |
| | UNC119 | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...] (314 aa) |
| | TNFRSF18 | TNF receptor superfamily member 18. (322 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (165 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | PLCG2 | Phosphoinositide phospholipase C. (1336 aa) |
| | LRRK1 | Leucine rich repeat kinase 1. (2014 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (326 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa) |
| | PECAM1 | Platelet and endothelial cell adhesion molecule 1. (803 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (919 aa) |
| | GFRA1 | GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (468 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (787 aa) |
| | SEMA4D | Semaphorin 4D; Belongs to the semaphorin family. (1067 aa) |
| | CD44 | CD44 antigen. (859 aa) |
| | HTR2A | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (512 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (263 aa) |
| | RELN | Reelin. (3459 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (523 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (1030 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1486 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa) |
| | PRNP | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (255 aa) |
| | ALK | Tyrosine-protein kinase receptor. (1631 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa) |
| | PIBF1 | Progesterone immunomodulatory binding factor 1. (757 aa) |
| | NOX4 | NADPH oxidase 4. (323 aa) |
| | ABI1 | Abl interactor 1. (508 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (458 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa) |
| | IL21 | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] (146 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1141 aa) |
| | TGFA | EGF-like domain-containing protein. (284 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | IL11 | Interleukin 11. (199 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | IL3 | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa) |
