STRINGSTRING
IL4 IL4 TNFRSF13C TNFRSF13C EXOSC3 EXOSC3 KMT5C KMT5C MSH2 MSH2 AKIRIN2 AKIRIN2 PELI1 PELI1 IL21 IL21 IL2 IL2 HMCES HMCES B9D2 B9D2 PAXIP1 PAXIP1 RIF1 RIF1 GPR183 GPR183 NCKAP1L NCKAP1L IL7 IL7 NOD2 NOD2 CD81 CD81 MMP14 MMP14 IL10 IL10 NFATC2 NFATC2 XBP1 XBP1 TP53BP1 TP53BP1 TFRC TFRC PPP2R3C PPP2R3C BCL6 BCL6 CD27 CD27 BST1 BST1 STAT5A STAT5A STAT5B STAT5B CARD11 CARD11 MAD2L2 MAD2L2 TBX21 TBX21 F1PP29_CANLF F1PP29_CANLF TLR9-2 TLR9-2 BAD BAD TNFSF13B TNFSF13B ATAD5 ATAD5 NSD2 NSD2 SASH3 SASH3 IL2RG IL2RG KMT5B KMT5B CD38 CD38 ENSCAFP00000044033 ENSCAFP00000044033 ENSCAFP00000044582 ENSCAFP00000044582 CD74 CD74 STAT6 STAT6 ENSCAFP00000048133 ENSCAFP00000048133 EXOSC6 EXOSC6 ENSCAFP00000049448 ENSCAFP00000049448 BMI1 BMI1 CDKN1A CDKN1A ENSCAFP00000050605 ENSCAFP00000050605 SHLD1 SHLD1 HV01_CANLF HV01_CANLF CD28 CD28 ENSCAFP00000052690 ENSCAFP00000052690 MEF2C MEF2C ENSCAFP00000054037 ENSCAFP00000054037 PTPRC PTPRC SYK SYK CD320 CD320 TNFSF13 TNFSF13 ENSCAFP00000055668 ENSCAFP00000055668 INPP5D INPP5D HV02_CANLF HV02_CANLF PCID2 PCID2 SH3KBP1 SH3KBP1 MORN5 MORN5 ENSCAFP00000062222 ENSCAFP00000062222 ADA ADA VAV3 VAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
TNFRSF13CTNF receptor superfamily member 13C. (286 aa)
EXOSC3Exosome component 3. (275 aa)
KMT5CLysine methyltransferase 5C. (559 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
AKIRIN2Akirin 2. (203 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
IL21Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] (146 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (357 aa)
B9D2Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
PAXIP1PAX interacting protein 1. (1035 aa)
RIF1Replication timing regulatory factor 1. (2549 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (375 aa)
NCKAP1LNCK associated protein 1 like. (1133 aa)
IL7Interleukin 7. (155 aa)
NOD2Uncharacterized protein. (1013 aa)
CD81Tetraspanin. (233 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
NFATC2Nuclear factor of activated T cells 2. (1086 aa)
XBP1BZIP domain-containing protein. (380 aa)
TP53BP1Tumor protein p53 binding protein 1. (1936 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (918 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
CD27CD27 molecule. (229 aa)
BST1Bone marrow stromal cell antigen 1. (311 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (196 aa)
TBX21T-box transcription factor 21. (535 aa)
F1PP29_CANLFUncharacterized protein. (499 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TNFSF13BTumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (370 aa)
ATAD5ATPase family AAA domain containing 5. (1825 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
SASH3SAM and SH3 domain containing 3. (381 aa)
IL2RGCytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa)
KMT5BLysine methyltransferase 5B. (888 aa)
CD38CD38 molecule. (361 aa)
ENSCAFP00000044033Ig-like domain-containing protein. (150 aa)
ENSCAFP00000044582Ig-like domain-containing protein. (144 aa)
CD74CD74 molecule. (272 aa)
STAT6Signal transducer and activator of transcription. (927 aa)
ENSCAFP00000048133Ig-like domain-containing protein. (138 aa)
EXOSC6Exosome component 6. (395 aa)
ENSCAFP00000049448Ig-like domain-containing protein. (105 aa)
BMI1RING-type domain-containing protein. (436 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
ENSCAFP00000050605Uncharacterized protein. (360 aa)
SHLD1Shieldin complex subunit 1. (259 aa)
HV01_CANLFIg heavy chain V region GOM. (474 aa)
CD28CD28 molecule. (246 aa)
ENSCAFP00000052690Uncharacterized protein. (70 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSCAFP00000054037Ig-like domain-containing protein. (150 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1385 aa)
SYKTyrosine-protein kinase. (699 aa)
CD320CD320 molecule. (282 aa)
TNFSF13TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa)
ENSCAFP00000055668Ig-like domain-containing protein. (142 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
HV02_CANLFIg heavy chain V region MOO. (150 aa)
PCID2PCI domain containing 2. (410 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (710 aa)
MORN5MORN repeat containing 5. (278 aa)
ENSCAFP00000062222Uncharacterized protein. (167 aa)
ADAAdenosine deaminase. (402 aa)
VAV3Vav guanine nucleotide exchange factor 3. (859 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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