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| | TRIML1 | Tripartite motif family like 1. (555 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (648 aa) |
| | MALT1 | MALT1 paracaspase. (758 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (650 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | EP300 | E1A binding protein p300. (2308 aa) |
| | TRAPPC9 | Trafficking protein particle complex 9. (1150 aa) |
| | IL18RAP | Interleukin 18 receptor accessory protein. (582 aa) |
| | TRIM14 | Tripartite motif containing 14. (445 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (964 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | ANKRD42 | Ankyrin repeat domain 42. (533 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (512 aa) |
| | TRIM80 | Uncharacterized protein. (615 aa) |
| | MYD88 | MYD88 innate immune signal transduction adaptor. (398 aa) |
| | SPHK1 | Sphingosine kinase 1. (487 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (621 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa) |
| | RPS3 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa) |
| | LOC483905 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (153 aa) |
| | CARD14 | Caspase recruitment domain family member 14. (1029 aa) |
| | NTS | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. (170 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2. (532 aa) |
| | TRIM34 | Uncharacterized protein. (487 aa) |
| | DDRGK1 | DDRGK domain containing 1. (390 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (595 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. (528 aa) |
| | TRIML2 | Tripartite motif family like 2. (443 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa) |
| | FER | Tyrosine-protein kinase Fer; Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell attachment and cell migration. Acts downstream of EGFR, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)- mediated signaling in mast cells. Plays a role in the regulation of mast cell [...] (823 aa) |
| | GREM1 | Gremlin 1, DAN family BMP antagonist. (230 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (669 aa) |
| | MTDH | Metadherin. (631 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | NOD2 | Uncharacterized protein. (1013 aa) |
| | RIPK4 | Receptor interacting serine/threonine kinase 4. (743 aa) |
| | CAPN3 | Calpain 3; Belongs to the peptidase C2 family. (821 aa) |
| | TRIM38 | Tripartite motif containing 38. (462 aa) |
| | SLCO3A1 | Solute carrier organic anion transporter family member. (692 aa) |
| | IRF9 | Uncharacterized protein. (1136 aa) |
| | TRIM27 | Tripartite motif containing 27. (462 aa) |
| | CAPN9 | Calpain 9; Belongs to the peptidase C2 family. (692 aa) |
| | PRDX3 | Thioredoxin domain-containing protein. (278 aa) |
| | NTSR1 | Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (421 aa) |
| | BTNL9 | Butyrophilin like 9. (541 aa) |
| | CRNN | Cornulin. (707 aa) |
| | DHX9 | DExH-box helicase 9. (1276 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (542 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | LTF | Uncharacterized protein; Belongs to the transferrin family. (708 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (685 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa) |
| | RNF25 | Ring finger protein 25. (459 aa) |
| | PPIA-2 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (156 aa) |
| | DHX33 | DEAH-box helicase 33. (371 aa) |
| | PRKCH | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (907 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TRIM25 | Tripartite motif containing 25. (631 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (793 aa) |
| | TRIM37 | Tripartite motif containing 37. (973 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa) |
| | ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1011 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (536 aa) |
| | PLCG2 | Phosphoinositide phospholipase C. (1336 aa) |
| | TERF2IP | TERF2 interacting protein. (403 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | CTH | Cystathionine gamma-lyase. (547 aa) |
| | TLR9-2 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa) |
| | TRAF1 | TNF receptor associated factor 1. (368 aa) |
| | TRIM32 | Tripartite motif containing 32. (655 aa) |
| | CLU | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself (By similarity). Binding to cell surface receptors triggers internalization of the chaperone-client complex and [...] (467 aa) |
| | J9NV93_CANLF | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (98 aa) |
| | EDA | Ectodysplasin A isoform EDA-A2; Belongs to the tumor necrosis factor family. (386 aa) |
| | TRIM62 | Tripartite motif containing 62. (415 aa) |
| | J9NXS3_CANLF | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (145 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa) |
| | MTPN | Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). (118 aa) |
| | J9P3Z4_CANLF | Uncharacterized protein. (153 aa) |
| | UBE2V1 | Ubiquitin conjugating enzyme E2 V1. (147 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (807 aa) |
| | ENSCAFP00000047134 | Proteasome endopeptidase complex. (216 aa) |
| | ENSCAFP00000047314 | Uncharacterized protein. (153 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (750 aa) |
| | PRKD2 | Protein kinase D2. (1018 aa) |
| | RIPK3 | Protein kinase domain-containing protein. (423 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ENSCAFP00000048153 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (199 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (560 aa) |
| | TRIM22 | Tripartite motif containing 22. (494 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (903 aa) |
| | TRIM6 | Uncharacterized protein. (487 aa) |
| | ENSCAFP00000053186 | annotation not available (147 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (485 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (718 aa) |
| | FLOT1 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (429 aa) |
| | ENSCAFP00000056313 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (136 aa) |
| | TRIM13 | Tripartite motif containing 13. (455 aa) |
| | ARHGEF2 | Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...] (1194 aa) |
| | MID2 | Midline 2. (761 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (869 aa) |
| | ERC1 | ELKS/RAB6-interacting/CAST family member 1. (1120 aa) |
| | TRIM68 | Tripartite motif containing 68. (485 aa) |
| | ENSCAFP00000060413 | Uncharacterized protein. (88 aa) |
| | CIB1 | Calcium and integrin binding 1. (234 aa) |
| | ENSCAFP00000061534 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | PPIA | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (234 aa) |
| | AGER | Advanced glycosylation end product-specific receptor variant C. (396 aa) |
| | TRIM8 | Tripartite motif containing 8. (592 aa) |
| | ENSCAFP00000062843 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (145 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (714 aa) |
| | RHEBL1 | RHEB like 1. (221 aa) |
| | RAB7B | RAB7B, member RAS oncogene family. (222 aa) |
