(23 nodes) Smooth muscle cell differentiation network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	NFATC4	Nuclear factor of activated T cells 4. (946 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (265 aa)
	ENG	Endoglin. (652 aa)
	TBX3	T-box transcription factor 3. (720 aa)
	NPNT	Nephronectin. (614 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (505 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	COMP	Cartilage oligomeric matrix protein. (891 aa)
	MRTFA	Myocardin related transcription factor A. (1025 aa)
	MRTFB	Myocardin related transcription factor B. (1113 aa)
	RAMP2	Uncharacterized protein. (374 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	TBX2	T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). (655 aa)
	QKI	Protein quaking; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). (335 aa)
	FOXF1	Forkhead box F1. (354 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	TMEM204	Transmembrane protein 204. (225 aa)
	MYOCD	Myocardin. (983 aa)
	BMP4	TGF_BETA_2 domain-containing protein. (409 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] (276 aa)
	EDNRA	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (426 aa)
	SRF	Serum response factor. (508 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSCAFP00000021935	ENSCAFP00000037127	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.873
BMP4	HEY1	ENSCAFP00000021935	ENSCAFP00000012336	TGF_BETA_2 domain-containing protein.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.476
BMP4	MEF2C	ENSCAFP00000021935	ENSCAFP00000053374	TGF_BETA_2 domain-containing protein.	Myocyte enhancer factor 2C.	0.437
BMP4	NOTCH1	ENSCAFP00000021935	ENSCAFP00000029073	TGF_BETA_2 domain-containing protein.	Notch receptor 1.	0.456
BMP4	TBX2	ENSCAFP00000021935	ENSCAFP00000037090	TGF_BETA_2 domain-containing protein.	T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity).	0.408
BMP4	TBX3	ENSCAFP00000021935	ENSCAFP00000043057	TGF_BETA_2 domain-containing protein.	T-box transcription factor 3.	0.534
FGF10	BMP4	ENSCAFP00000037127	ENSCAFP00000021935	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	TGF_BETA_2 domain-containing protein.	0.873
FOXF1	MYOCD	ENSCAFP00000029503	ENSCAFP00000026366	Forkhead box F1.	Myocardin.	0.591
FOXF1	SRF	ENSCAFP00000029503	ENSCAFP00000002675	Forkhead box F1.	Serum response factor.	0.527
HEY1	BMP4	ENSCAFP00000012336	ENSCAFP00000021935	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	TGF_BETA_2 domain-containing protein.	0.476
HEY1	NOTCH1	ENSCAFP00000012336	ENSCAFP00000029073	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	Notch receptor 1.	0.625
MEF2C	BMP4	ENSCAFP00000053374	ENSCAFP00000021935	Myocyte enhancer factor 2C.	TGF_BETA_2 domain-containing protein.	0.437
MEF2C	MESP1	ENSCAFP00000053374	ENSCAFP00000040947	Myocyte enhancer factor 2C.	Mesoderm posterior bHLH transcription factor 1.	0.423
MEF2C	MYOCD	ENSCAFP00000053374	ENSCAFP00000026366	Myocyte enhancer factor 2C.	Myocardin.	0.699
MESP1	MEF2C	ENSCAFP00000040947	ENSCAFP00000053374	Mesoderm posterior bHLH transcription factor 1.	Myocyte enhancer factor 2C.	0.423
MRTFA	SRF	ENSCAFP00000059792	ENSCAFP00000002675	Myocardin related transcription factor A.	Serum response factor.	0.972
MRTFB	SRF	ENSCAFP00000063528	ENSCAFP00000002675	Myocardin related transcription factor B.	Serum response factor.	0.863
MYOCD	FOXF1	ENSCAFP00000026366	ENSCAFP00000029503	Myocardin.	Forkhead box F1.	0.591
MYOCD	MEF2C	ENSCAFP00000026366	ENSCAFP00000053374	Myocardin.	Myocyte enhancer factor 2C.	0.699
MYOCD	SRF	ENSCAFP00000026366	ENSCAFP00000002675	Myocardin.	Serum response factor.	0.976