STRINGSTRING
OAS2 OAS2 CGAS CGAS GPAM GPAM CLPB CLPB ARMC5 ARMC5 LOC100683567 LOC100683567 LOC100687778 LOC100687778 TRIM56 TRIM56 LOC100683045 LOC100683045 TRIM8 TRIM8 ZMYND11 ZMYND11 ENSCAFP00000060619 ENSCAFP00000060619 PQBP1 PQBP1 LOC100688005 LOC100688005 IFIT1 IFIT1 ENSCAFP00000059379 ENSCAFP00000059379 ENSCAFP00000059302 ENSCAFP00000059302 FAM71E1 FAM71E1 MID2 MID2 IFNAR2 IFNAR2 TRIM13 TRIM13 LOC100683265 LOC100683265 POLR3A POLR3A DDX1 DDX1 POLR3H POLR3H MARCHF2 MARCHF2 BPIFA1 BPIFA1 LOC102153214 LOC102153214 IFI44L IFI44L ENSCAFP00000055760 ENSCAFP00000055760 LOC100682977 LOC100682977 ZDHHC1 ZDHHC1 G3BP1 G3BP1 PTPRC PTPRC LOC100687857 LOC100687857 LOC100688084 LOC100688084 IFNA7 IFNA7 LOC100686162 LOC100686162 ATG16L1 ATG16L1 LOC100685213 LOC100685213 ENSCAFP00000051822 ENSCAFP00000051822 IFI6 IFI6 MX1 MX1 TRIM22 TRIM22 LOC100683123 LOC100683123 ENSCAFP00000049600 ENSCAFP00000049600 TREX1 TREX1 PHB2 PHB2 PML PML LOC478404 LOC478404 IRF2 IRF2 STAT1 STAT1 SERINC5 SERINC5 RIPK3 RIPK3 LOC100687928 LOC100687928 ABCF3 ABCF3 BECN1 BECN1 LOC100683202 LOC100683202 LOC100687692 LOC100687692 IFNA5 IFNA5 LOC100683416 LOC100683416 IFIT3 IFIT3 IFI27L2 IFI27L2 TLR3 TLR3 TLR7 TLR7 IFNLR1 IFNLR1 DDIT4 DDIT4 J9P9X2_CANLF J9P9X2_CANLF J9P7D2_CANLF J9P7D2_CANLF OPRK1 OPRK1 NDUFAF4 NDUFAF4 EXOSC5 EXOSC5 J9P0Q7_CANLF J9P0Q7_CANLF AGBL4 AGBL4 J9NZL9_CANLF J9NZL9_CANLF BST2 BST2 SENP7 SENP7 KCNJ8 KCNJ8 NMB NMB BNIP3L BNIP3L APOBEC3Z1 APOBEC3Z1 BNIP3 BNIP3 TRIM32 TRIM32 PMAIP1 PMAIP1 CXCL10 CXCL10 F1PHY4_CANLF F1PHY4_CANLF TLR9-2 TLR9-2 LOC609445 LOC609445 POLR3K POLR3K CARD9 CARD9 NCBP3 NCBP3 ISG15 ISG15 ATAD3A ATAD3A TTC4 TTC4 PLA2G10 PLA2G10 ZBP1 ZBP1 RNF135 RNF135 RIOK3 RIOK3 SHFL SHFL ILF3 ILF3 AKAP1 AKAP1 TRIM25 TRIM25 ADAR ADAR PHB PHB PYCARD PYCARD DHX15 DHX15 DHX58 DHX58 NLRP1 NLRP1 PRF1 PRF1 DDX50 DDX50 MAP3K14 MAP3K14 SETD2 SETD2 RNASEL RNASEL STAT2 STAT2 IL23A IL23A DDX60 DDX60 OAS3 OAS3 OAS1 OAS1 TRIM35 TRIM35 DHX36 DHX36 SAMHD1 SAMHD1 VAMP8 VAMP8 CHMP3 CHMP3 LSM14A LSM14A IFIT5 IFIT5 CNOT7 CNOT7 F6Y518_CANLF F6Y518_CANLF NLRP6 NLRP6 EIF2AK2 EIF2AK2 STING1 STING1 E2REW2_CANLF E2REW2_CANLF LOC612539 LOC612539 F1PPY8_CANLF F1PPY8_CANLF MYD88 MYD88 UNC13D UNC13D TRIM80 TRIM80 AGBL5 AGBL5 ABCC9 ABCC9 TRIM27 TRIM27 ISG20 ISG20 IL29L IL29L ZNFX1 ZNFX1 POLR3C POLR3C OASL-2 OASL-2 OASL OASL IFIT2 IFIT2 SERINC3 SERINC3 POLR3D POLR3D F2RL1 F2RL1 IRF3 IRF3 CLEC4F CLEC4F RSAD2 RSAD2 LOC484356 LOC484356 NCBP1 NCBP1 DDX58 DDX58 IFNK IFNK IFNB1 IFNB1 IRF5 IRF5 EXOSC4 EXOSC4 APOBEC3Z3 APOBEC3Z3 IRF1 IRF1 IFNG IFNG NMBR NMBR TICAM2 TICAM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OAS22'-5'-oligoadenylate synthetase 2. (717 aa)
CGASCyclic GMP-AMP synthase. (501 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (882 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (713 aa)
ARMC5Armadillo repeat containing 5. (976 aa)
LOC100683567Uncharacterized protein. (196 aa)
LOC100687778Interferon alpha-1/2-like. (187 aa)
TRIM56Tripartite motif containing 56. (771 aa)
LOC100683045Interferon alpha-1/2-like. (187 aa)
TRIM8Tripartite motif containing 8. (592 aa)
ZMYND11Zinc finger MYND-type containing 11. (617 aa)
ENSCAFP00000060619Uncharacterized protein. (124 aa)
PQBP1Polyglutamine binding protein 1. (358 aa)
LOC100688005Interferon alpha-1/2-like. (187 aa)
IFIT1Interferon induced protein with tetratricopeptide repeats 1. (514 aa)
ENSCAFP00000059379Uncharacterized protein. (172 aa)
ENSCAFP00000059302Uncharacterized protein. (151 aa)
FAM71E1Family with sequence similarity 71 member E1. (237 aa)
MID2Midline 2. (761 aa)
IFNAR2Uncharacterized protein. (522 aa)
TRIM13Tripartite motif containing 13. (455 aa)
LOC100683265Interferon alpha-1/2-like. (187 aa)
POLR3ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1402 aa)
DDX1DEAD-box helicase 1. (784 aa)
POLR3HRNA polymerase III subunit H. (223 aa)
MARCHF2Membrane associated ring-CH-type finger 2. (271 aa)
BPIFA1BPI fold containing family A member 1. (318 aa)
LOC102153214Uncharacterized protein. (494 aa)
IFI44LInterferon induced protein 44 like. (524 aa)
ENSCAFP00000055760V-SNARE coiled-coil homology domain-containing protein. (107 aa)
LOC100682977Interferon alpha-1/2-like. (187 aa)
ZDHHC1Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (511 aa)
G3BP1G3BP stress granule assembly factor 1. (461 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1385 aa)
LOC100687857Uncharacterized protein. (187 aa)
LOC100688084Interferon alpha-1/2. (187 aa)
IFNA7Interferon-alpha. (187 aa)
LOC100686162Uncharacterized protein. (175 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
LOC100685213Interferon alpha-1/2. (187 aa)
ENSCAFP00000051822Uncharacterized protein. (51 aa)
IFI6Interferon alpha inducible protein 6. (197 aa)
MX1Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV). (791 aa)
TRIM22Tripartite motif containing 22. (494 aa)
LOC100683123Interferon alpha-1/2-like. (187 aa)
ENSCAFP00000049600Uncharacterized protein. (108 aa)
TREX1Three prime repair exonuclease 1. (373 aa)
PHB2Prohibitin. (319 aa)
PMLPromyelocytic leukemia. (933 aa)
LOC478404Uncharacterized protein. (528 aa)
IRF2Interferon regulatory factor 2. (392 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
SERINC5Serine incorporator 5. (483 aa)
RIPK3Protein kinase domain-containing protein. (423 aa)
LOC100687928Interferon alpha-1/2. (187 aa)
ABCF3ATP binding cassette subfamily F member 3. (740 aa)
BECN1Beclin 1. (471 aa)
LOC100683202Interferon alpha-1/2; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa)
LOC100687692Uncharacterized protein. (187 aa)
IFNA5Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa)
LOC100683416Uncharacterized protein. (178 aa)
IFIT3Interferon induced protein with tetratricopeptide repeats 3. (491 aa)
IFI27L2Uncharacterized protein. (110 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
IFNLR1Interferon lambda receptor 1. (502 aa)
DDIT4DNA damage inducible transcript 4. (606 aa)
J9P9X2_CANLFProhibitin. (301 aa)
J9P7D2_CANLFRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (78 aa)
OPRK1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (380 aa)
NDUFAF4NADH:ubiquinone oxidoreductase complex assembly factor 4. (366 aa)
EXOSC5Exosome component 5. (235 aa)
J9P0Q7_CANLFProhibitin. (160 aa)
AGBL4ATP/GTP binding protein like 4. (494 aa)
J9NZL9_CANLFUncharacterized protein. (85 aa)
BST2Bone marrow stromal cell antigen 2. (188 aa)
SENP7ULP_PROTEASE domain-containing protein. (1047 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
NMBNeuromedin B. (126 aa)
BNIP3LUncharacterized protein. (204 aa)
APOBEC3Z1CMP/dCMP-type deaminase domain-containing protein. (197 aa)
BNIP3BCL2 interacting protein 3. (354 aa)
TRIM32Tripartite motif containing 32. (655 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. (54 aa)
CXCL10C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] (98 aa)
F1PHY4_CANLFCMP/dCMP-type deaminase domain-containing protein. (123 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
LOC609445Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (428 aa)
POLR3KDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
NCBP3Nuclear cap binding subunit 3. (626 aa)
ISG15ISG15 ubiquitin like modifier. (168 aa)
ATAD3AATPase family AAA domain containing 3A. (591 aa)
TTC4Tetratricopeptide repeat domain 4. (388 aa)
PLA2G10Phospholipase A(2). (153 aa)
ZBP1Z-DNA binding protein 1. (242 aa)
RNF135Ring finger protein 135. (402 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
SHFLShiftless antiviral inhibitor of ribosomal frameshifting. (286 aa)
ILF3Interleukin enhancer binding factor 3. (900 aa)
AKAP1A-kinase anchoring protein 1. (882 aa)
TRIM25Tripartite motif containing 25. (631 aa)
ADARAdenosine deaminase RNA specific. (929 aa)
PHBProhibitin. (262 aa)
PYCARDPYD and CARD domain containing. (195 aa)
DHX15DEAH-box helicase 15. (795 aa)
DHX58DExH-box helicase 58. (678 aa)
NLRP1NLR family pyrin domain containing 1. (1432 aa)
PRF1Perforin 1. (579 aa)
DDX50DExD-box helicase 50. (739 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2562 aa)
RNASELRibonuclease L. (724 aa)
STAT2Signal transducer and activator of transcription. (844 aa)
IL23AInterleukin 23 subunit alpha. (193 aa)
DDX60DExD/H-box helicase 60. (1708 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1140 aa)
OAS12'-5'-oligoadenylate synthetase 1. (399 aa)
TRIM35Tripartite motif containing 35. (493 aa)
DHX36DEAH-box helicase 36. (1122 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
CHMP3Uncharacterized protein. (292 aa)
LSM14ALSM14A mRNA processing body assembly factor. (448 aa)
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (483 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
F6Y518_CANLFIRF-3 domain-containing protein. (90 aa)
NLRP6NLR family pyrin domain containing 6. (911 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (532 aa)
STING1Transmembrane protein 173. (375 aa)
E2REW2_CANLFUncharacterized protein. (196 aa)
LOC612539Uncharacterized protein. (189 aa)
F1PPY8_CANLFRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (83 aa)
MYD88MYD88 innate immune signal transduction adaptor. (398 aa)
UNC13DUnc-13 homolog D. (1210 aa)
TRIM80Uncharacterized protein. (615 aa)
AGBL5ATP/GTP binding protein like 5. (884 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
TRIM27Tripartite motif containing 27. (462 aa)
ISG20Interferon stimulated exonuclease gene 20. (171 aa)
IL29LInterferon lambda. (190 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1918 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
OASL-2Oligoadenylate synthetase-like 2. (519 aa)
OASL2'-5' oligoadenylate synthetase-like 1. (515 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (480 aa)
SERINC3Serine incorporator 3. (473 aa)
POLR3DRNA polymerase III subunit D. (398 aa)
F2RL1Protease-activated receptor 2. (397 aa)
IRF3Interferon regulatory factor 3. (281 aa)
CLEC4FC-type lectin domain family 4 member F. (623 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (361 aa)
LOC484356Uncharacterized protein. (377 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
DDX58DExD/H-box helicase 58. (925 aa)
IFNKInterferon kappa. (209 aa)
IFNB1Interferon-beta. (186 aa)
IRF5Interferon regulatory factor 5. (605 aa)
EXOSC4Exosome component 4. (245 aa)
APOBEC3Z3CMP/dCMP-type deaminase domain-containing protein. (191 aa)
IRF1Interferon regulatory factor 1. (437 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
TICAM2TIR domain-containing protein. (238 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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