(47 nodes) Retina morphogenesis in camera-type eye network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BBS4	Ariadne RBR E3 ubiquitin protein ligase 1. (908 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (601 aa)
	PROM1	Prominin 1. (868 aa)
	CRB2	Crumbs cell polarity complex component 2. (1285 aa)
	RDH13	Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa)
	FAT3	FAT atypical cadherin 3. (4612 aa)
	STAT3	Signal transducer and activator of transcription. (793 aa)
	THRB	Thyroid hormone receptor beta. (476 aa)
	IGSF22	Immunoglobulin superfamily member 22. (1342 aa)
	LOC100856175	Uncharacterized protein. (2851 aa)
	THY1	Ig-like domain-containing protein. (161 aa)
	RPGRIP1L	RPGRIP1 like. (1278 aa)
	LOC100855804	Uncharacterized protein. (2797 aa)
	SOX8	SRY-box 8. (462 aa)
	RORB	RAR related orphan receptor B. (470 aa)
	NF2	Neurofibromin 2. (597 aa)
	GNAT2	G protein subunit alpha transducin 2. (354 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	LHX1	LIM homeobox 1. (406 aa)
	TTC8	Tetratricopeptide repeat domain 8 isoform 1. (515 aa)
	MEGF11	Multiple EGF like domains 11. (1140 aa)
	SDK1	Sidekick cell adhesion molecule 1. (2125 aa)
	ROM1	Retinal outer segment membrane protein 1. (351 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (747 aa)
	MYPN	Myopalladin. (1322 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	NRL	Neural retina leucine zipper. (257 aa)
	CABP4	Calcium binding protein 4. (277 aa)
	CRB1	Crumbs cell polarity complex component 1. (1433 aa)
	FOXN4	Forkhead box N4. (523 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1583 aa)
	CDON	Cell adhesion associated, oncogene regulated. (1235 aa)
	IMPG2	Interphotoreceptor matrix proteoglycan 2. (1234 aa)
	HIPK1	Homeodomain interacting protein kinase 1. (1298 aa)
	CALB1	Calbindin 1. (261 aa)
	USH1C	USH1 protein network component harmonin. (898 aa)
	PDE6C	Phosphodiesterase. (845 aa)
	MAN2A1	Alpha-mannosidase. (1106 aa)
	RP1	Oxygen-regulated protein 1; Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity). (2149 aa)
	SDK2	Sidekick cell adhesion molecule 2. (2120 aa)
	VSX1	Visual system homeobox 1. (364 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1286 aa)
	TSPAN12	Tetraspanin. (305 aa)
	ZHX2	Zinc fingers and homeoboxes 2. (838 aa)
	AHI1	Abelson helper integration site 1. (1178 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHI1	BBS4	ENSCAFP00000000339	ENSCAFP00000057999	Abelson helper integration site 1.	Ariadne RBR E3 ubiquitin protein ligase 1.	0.494
AHI1	ROM1	ENSCAFP00000000339	ENSCAFP00000023214	Abelson helper integration site 1.	Retinal outer segment membrane protein 1.	0.457
AHI1	RPGRIP1L	ENSCAFP00000000339	ENSCAFP00000041439	Abelson helper integration site 1.	RPGRIP1 like.	0.880
BBS4	AHI1	ENSCAFP00000057999	ENSCAFP00000000339	Ariadne RBR E3 ubiquitin protein ligase 1.	Abelson helper integration site 1.	0.494
BBS4	MEGF11	ENSCAFP00000057999	ENSCAFP00000025436	Ariadne RBR E3 ubiquitin protein ligase 1.	Multiple EGF like domains 11.	0.430
BBS4	RPGRIP1L	ENSCAFP00000057999	ENSCAFP00000041439	Ariadne RBR E3 ubiquitin protein ligase 1.	RPGRIP1 like.	0.557
BBS4	TTC8	ENSCAFP00000057999	ENSCAFP00000025761	Ariadne RBR E3 ubiquitin protein ligase 1.	Tetratricopeptide repeat domain 8 isoform 1.	0.998
CABP4	GNAT2	ENSCAFP00000016971	ENSCAFP00000029355	Calcium binding protein 4.	G protein subunit alpha transducin 2.	0.407
CABP4	ROM1	ENSCAFP00000016971	ENSCAFP00000023214	Calcium binding protein 4.	Retinal outer segment membrane protein 1.	0.491
CALB1	FOXN4	ENSCAFP00000013256	ENSCAFP00000016069	Calbindin 1.	Forkhead box N4.	0.420
CALB1	LHX1	ENSCAFP00000013256	ENSCAFP00000026343	Calbindin 1.	LIM homeobox 1.	0.423
CRB1	CRB2	ENSCAFP00000016724	ENSCAFP00000053879	Crumbs cell polarity complex component 1.	Crumbs cell polarity complex component 2.	0.914
CRB2	CRB1	ENSCAFP00000053879	ENSCAFP00000016724	Crumbs cell polarity complex component 2.	Crumbs cell polarity complex component 1.	0.914
DLL1	NOTCH1	ENSCAFP00000006075	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.996
FOXN4	CALB1	ENSCAFP00000016069	ENSCAFP00000013256	Forkhead box N4.	Calbindin 1.	0.420
FOXN4	VSX1	ENSCAFP00000016069	ENSCAFP00000006497	Forkhead box N4.	Visual system homeobox 1.	0.523
GNAT2	CABP4	ENSCAFP00000029355	ENSCAFP00000016971	G protein subunit alpha transducin 2.	Calcium binding protein 4.	0.407
GNAT2	NRL	ENSCAFP00000029355	ENSCAFP00000017429	G protein subunit alpha transducin 2.	Neural retina leucine zipper.	0.482
GNAT2	PDE6C	ENSCAFP00000029355	ENSCAFP00000011712	G protein subunit alpha transducin 2.	Phosphodiesterase.	0.943
GNAT2	ROM1	ENSCAFP00000029355	ENSCAFP00000023214	G protein subunit alpha transducin 2.	Retinal outer segment membrane protein 1.	0.774