STRINGSTRING
TCF7L2 TCF7L2 STK4 STK4 TCF7 TCF7 FGF9 FGF9 PTEN PTEN WNT7B WNT7B SCYL2 SCYL2 WNT4 WNT4 WNT1 WNT1 FZD4 FZD4 RECK RECK LGR4 LGR4 BCL9L BCL9L AXIN1 AXIN1 RAPGEF1 RAPGEF1 CDH3 CDH3 PLPP3 PLPP3 LEF1 LEF1 WNT8A WNT8A ENSCAFP00000057500 ENSCAFP00000057500 SDC1 SDC1 LRP6 LRP6 WNT7A WNT7A SOSTDC1 SOSTDC1 WNT9B WNT9B YAP1 YAP1 WNT6 WNT6 SFRP1 SFRP1 EDA EDA SFRP4 SFRP4 FRZB FRZB GSK3B GSK3B FZD7 FZD7 WNT2B WNT2B DVL1 DVL1 GPC3 GPC3 PYGO2 PYGO2 CTDNEP1 CTDNEP1 WNT3A WNT3A EXT1 EXT1 FZD6 FZD6 STK3 STK3 DVL2 DVL2 PYGO1 PYGO1 WNT5B WNT5B JUP JUP WNT10A WNT10A FZD2 FZD2 DIXDC1 DIXDC1 FZD5 FZD5 FZD9 FZD9 DVL3 DVL3 DISC1 DISC1 BCL9 BCL9 LRP5 LRP5 EDN1 EDN1 WNT8B WNT8B SFRP5 SFRP5 WNT10B WNT10B SIAH2 SIAH2 SFRP2 SFRP2 FZD3 FZD3 HESX1 HESX1 TCF7L1 TCF7L1 EDNRA EDNRA LATS2 LATS2 FZD10 FZD10 RAB5A RAB5A WNT11 WNT11 CTNNB1 CTNNB1 GATA3 GATA3 FOXO3 FOXO3 FZD8 FZD8 WNT16 WNT16 CAV1 CAV1 FZD1 FZD1 WNT3 WNT3 WNT9A WNT9A SOST SOST WNT2 WNT2 WNT5A WNT5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF7L2Transcription factor 7 like 2. (565 aa)
STK4Serine/threonine kinase 4. (514 aa)
TCF7Transcription factor 7. (484 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (471 aa)
SCYL2SCY1 like pseudokinase 2. (1121 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (619 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (1040 aa)
BCL9LBCL9 like. (1481 aa)
AXIN1Axin 1. (992 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1297 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (933 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
LEF1Lymphoid enhancer binding factor 1. (481 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
ENSCAFP00000057500Uncharacterized protein. (184 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (317 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
YAP1Yes associated protein 1. (325 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (339 aa)
SFRP1Secreted frizzled related protein 1. (458 aa)
EDAEctodysplasin A isoform EDA-A2; Belongs to the tumor necrosis factor family. (386 aa)
SFRP4Secreted frizzled related protein 4. (347 aa)
FRZBFrizzled related protein. (168 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (910 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (613 aa)
PYGO2Pygopus family PHD finger 2. (405 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (450 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
FZD6Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (712 aa)
STK3Serine/threonine kinase 3. (491 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
PYGO1Pygopus family PHD finger 1. (417 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
JUPUncharacterized protein. (744 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
DIXDC1DIX domain containing 1. (704 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (589 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (594 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
DISC1DISC1 scaffold protein. (848 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1583 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SFRP5Secreted frizzled related protein 5. (179 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (311 aa)
SFRP2Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. (253 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
HESX1HESX homeobox 1. (186 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (426 aa)
LATS2Non-specific serine/threonine protein kinase. (1085 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (744 aa)
GATA3GATA binding protein 3. (444 aa)
FOXO3Forkhead box O3. (671 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (280 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (651 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (414 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
SOSTSclerostin. (213 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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