(13 nodes) Positive regulation of macrophage cytokine production network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	NOD1	Nucleotide binding oligomerization domain containing 1. (964 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (398 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	NOD2	Uncharacterized protein. (1013 aa)
	SIRT1	Sirtuin 1. (745 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	SEMA7A	Semaphorin 7A; Belongs to the semaphorin family. (632 aa)
	CARD9	Caspase recruitment domain family member 9. (536 aa)
	PLCG2	Phosphoinositide phospholipase C. (1336 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa)
	CD74	CD74 molecule. (272 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD9	MYD88	ENSCAFP00000029129	ENSCAFP00000007386	Caspase recruitment domain family member 9.	MYD88 innate immune signal transduction adaptor.	0.685
CARD9	NOD2	ENSCAFP00000029129	ENSCAFP00000014425	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.654
CARD9	PYCARD	ENSCAFP00000029129	ENSCAFP00000024803	Caspase recruitment domain family member 9.	PYD and CARD domain containing.	0.590
CARD9	RIPK2	ENSCAFP00000029129	ENSCAFP00000013170	Caspase recruitment domain family member 9.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.927
MYD88	CARD9	ENSCAFP00000007386	ENSCAFP00000029129	MYD88 innate immune signal transduction adaptor.	Caspase recruitment domain family member 9.	0.685
MYD88	NOD1	ENSCAFP00000007386	ENSCAFP00000004572	MYD88 innate immune signal transduction adaptor.	Nucleotide binding oligomerization domain containing 1.	0.681
MYD88	NOD2	ENSCAFP00000007386	ENSCAFP00000014425	MYD88 innate immune signal transduction adaptor.	Uncharacterized protein.	0.748
MYD88	PYCARD	ENSCAFP00000007386	ENSCAFP00000024803	MYD88 innate immune signal transduction adaptor.	PYD and CARD domain containing.	0.652
MYD88	RIPK2	ENSCAFP00000007386	ENSCAFP00000013170	MYD88 innate immune signal transduction adaptor.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.527
MYD88	SIRT1	ENSCAFP00000007386	ENSCAFP00000019617	MYD88 innate immune signal transduction adaptor.	Sirtuin 1.	0.458
MYD88	TLR3	ENSCAFP00000007386	ENSCAFP00000044568	MYD88 innate immune signal transduction adaptor.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.978
MYD88	TLR7	ENSCAFP00000007386	ENSCAFP00000043898	MYD88 innate immune signal transduction adaptor.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.992
NOD1	MYD88	ENSCAFP00000004572	ENSCAFP00000007386	Nucleotide binding oligomerization domain containing 1.	MYD88 innate immune signal transduction adaptor.	0.681
NOD1	NOD2	ENSCAFP00000004572	ENSCAFP00000014425	Nucleotide binding oligomerization domain containing 1.	Uncharacterized protein.	0.926
NOD1	PYCARD	ENSCAFP00000004572	ENSCAFP00000024803	Nucleotide binding oligomerization domain containing 1.	PYD and CARD domain containing.	0.565
NOD1	RIPK2	ENSCAFP00000004572	ENSCAFP00000013170	Nucleotide binding oligomerization domain containing 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.990
NOD1	TLR3	ENSCAFP00000004572	ENSCAFP00000044568	Nucleotide binding oligomerization domain containing 1.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.634
NOD1	TLR7	ENSCAFP00000004572	ENSCAFP00000043898	Nucleotide binding oligomerization domain containing 1.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.592
NOD2	CARD9	ENSCAFP00000014425	ENSCAFP00000029129	Uncharacterized protein.	Caspase recruitment domain family member 9.	0.654
NOD2	MYD88	ENSCAFP00000014425	ENSCAFP00000007386	Uncharacterized protein.	MYD88 innate immune signal transduction adaptor.	0.748