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| | TRIP6 | Thyroid hormone receptor interactor 6. (478 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | VEGFB | Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa) |
| | CNOT9 | CCR4-NOT transcription complex subunit 9. (299 aa) |
| | FGF7 | Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). (194 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (732 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (312 aa) |
| | F1PAW5_CANLF | Uncharacterized protein. (286 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | PGF | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (213 aa) |
| | FLRT2 | Fibronectin leucine rich transmembrane protein 2. (660 aa) |
| | ESM1 | Endothelial cell specific molecule 1. (184 aa) |
| | IL23R | Interleukin 23 receptor. (631 aa) |
| | PSPN | Persephin. (145 aa) |
| | NRTN | Neurturin. (195 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | GLMN | Glomulin, FKBP associated protein. (599 aa) |
| | CDH5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (775 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (919 aa) |
| | TIMM50 | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (356 aa) |
| | KLB | Klotho beta. (1044 aa) |
| | FGF5 | Fibroblast growth factor 5; Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Belongs to the heparin-binding growth factors family. (559 aa) |
| | FLRT3 | Fibronectin leucine rich transmembrane protein 3. (649 aa) |
| | SNX2 | Sorting nexin 2. (519 aa) |
| | LINGO2 | Leucine rich repeat and Ig domain containing 2. (606 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | PTPRJ | Protein tyrosine phosphatase receptor type J. (1229 aa) |
| | IL1RN | Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). Belongs to the IL-1 family. (158 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa) |
| | EREG | Epiregulin. (160 aa) |
| | AREG | Amphiregulin. (275 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | IL1F10 | Interleukin-1. (177 aa) |
| | IL37 | Interleukin-1. (288 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (495 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | GDNF | Glial cell derived neurotrophic factor. (211 aa) |
| | J9P9V2_CANLF | Uncharacterized protein. (73 aa) |
| | LOC102153191 | Uncharacterized protein. (210 aa) |
| | FRS3 | Fibroblast growth factor receptor substrate 3. (496 aa) |
| | PDCL3 | Phosducin like 3. (303 aa) |
| | ENSCAFP00000043591 | Uncharacterized protein. (176 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1324 aa) |
| | FGF18 | Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (335 aa) |
| | NPTN | Neuroplastin. (367 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (250 aa) |
| | PDGFD | Platelet derived growth factor D. (398 aa) |
| | DAB2IP | DAB2 interacting protein. (1283 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (263 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (246 aa) |
| | CCDC88A | Coiled-coil domain containing 88A. (1903 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (423 aa) |
| | IL36G | Interleukin 36 gamma. (194 aa) |
| | IL9 | Interleukin 9. (139 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (341 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | SNX1 | Sorting nexin 1. (563 aa) |
| | BTC | Betacellulin. (187 aa) |
| | EFEMP1 | EGF containing fibulin extracellular matrix protein 1. (521 aa) |
| | IL6ST | Uncharacterized protein. (954 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (821 aa) |
| | CSF3 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes; Belongs to the IL-6 superfamily. (204 aa) |
| | LINGO1 | Leucine rich repeat and Ig domain containing 1. (768 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (859 aa) |
| | NCSTN | Ncstrn_small domain-containing protein. (708 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1283 aa) |
| | RNF126 | Uncharacterized protein. (794 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (327 aa) |
| | IL36B | Interleukin-1. (164 aa) |
| | IL36RN | Interleukin-1. (155 aa) |
| | FER | Tyrosine-protein kinase Fer; Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell attachment and cell migration. Acts downstream of EGFR, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)- mediated signaling in mast cells. Plays a role in the regulation of mast cell [...] (823 aa) |
| | ERAP1 | Aminopeptidase. (942 aa) |
| | GREM1 | Gremlin 1, DAN family BMP antagonist. (230 aa) |
| | IL7 | Interleukin 7. (155 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa) |
| | CYSTM1 | Cysteine rich transmembrane module containing 1. (102 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (466 aa) |
| | FGF8 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). (203 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (975 aa) |
| | VEGFD | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa) |
| | ECM1 | Extracellular matrix protein 1. (542 aa) |
| | RNF41 | Ring finger protein 41. (246 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (508 aa) |
| | IL3 | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa) |
| | PDCL2 | Phosducin like 2. (242 aa) |
| | AGR2 | Anterior gradient 2, protein disulphide isomerase family member. (175 aa) |
| | IL11 | Interleukin 11. (199 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | TGFA | EGF-like domain-containing protein. (284 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | IL21 | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] (146 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa) |
| | CBLC | Cbl proto-oncogene C. (497 aa) |
| | MYD88 | MYD88 innate immune signal transduction adaptor. (398 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | PIBF1 | Progesterone immunomodulatory binding factor 1. (757 aa) |
| | SNX4 | Sorting nexin 4. (433 aa) |
