STRINGSTRING
SF3A3 SF3A3 SNRPD2-2 SNRPD2-2 CDC5L CDC5L SYNCRIP SYNCRIP CDC40 CDC40 CWC15 CWC15 SNRPD2 SNRPD2 C1H19orf54 C1H19orf54 CRNKL1 CRNKL1 EIF4A3 EIF4A3 MTREX MTREX CWC27 CWC27 PPWD1 PPWD1 ZCCHC8 ZCCHC8 AQR AQR PLRG1 PLRG1 DDX23 DDX23 BCAS2 BCAS2 SNRPN SNRPN SNRPA1 SNRPA1 SF3B1 SF3B1 SNRNP40 SNRNP40 RBM8A RBM8A DDX5 DDX5 TFIP11 TFIP11 RBM44 RBM44 SF3A1 SF3A1 LOC478183 LOC478183 SRRM1 SRRM1 SF3B2 SF3B2 SART1 SART1 HNRNPR HNRNPR ADIPOQ ADIPOQ SNRPD3 SNRPD3 PNN PNN EFTUD2 EFTUD2 DHX8 DHX8 ESS2 ESS2 PPIL2 PPIL2 HNRNPU HNRNPU WDR83 WDR83 SLU7 SLU7 LOC100685327 LOC100685327 SRSF1 SRSF1 WDR25 WDR25 RBM22 RBM22 SNRPD1 SNRPD1 RBMX RBMX SNRPB SNRPB CACTIN CACTIN PRPF8 PRPF8 LSM7 LSM7 SF3B3 SF3B3 DHX38 DHX38 SYF2 SYF2 E2RPP3_CANLF E2RPP3_CANLF SNRPB2 SNRPB2 J9NRX2_CANLF J9NRX2_CANLF J9NS74_CANLF J9NS74_CANLF MAGOHB MAGOHB ENSCAFP00000038104 ENSCAFP00000038104 DDX41 DDX41 PABPC1 PABPC1 SNW1 SNW1 C11H5orf63 C11H5orf63 SF3A2 SF3A2 J9P7Q9_CANLF J9P7Q9_CANLF PPIE PPIE LOC100686524 LOC100686524 SNRPD3-2 SNRPD3-2 CWC22 CWC22 J9PAH1_CANLF J9PAH1_CANLF XAB2 XAB2 J9PBG0_CANLF J9PBG0_CANLF SNRPG-2 SNRPG-2 PRPF19 PRPF19 LSM3-2 LSM3-2 LSM3-3 LSM3-3 LSM3-4 LSM3-4 FRG1 FRG1 ENSCAFP00000048678 ENSCAFP00000048678 LSM3 LSM3 GPATCH1 GPATCH1 SNRPG SNRPG SRRM2 SRRM2 ENSCAFP00000051373 ENSCAFP00000051373 ENSCAFP00000051873 ENSCAFP00000051873 SF3B6 SF3B6 PRPF4B PRPF4B ENSCAFP00000052764 ENSCAFP00000052764 ENSCAFP00000053603 ENSCAFP00000053603 BUD31 BUD31 ENSCAFP00000054298 ENSCAFP00000054298 PRPF6 PRPF6 PPIL1 PPIL1 ENSCAFP00000057917 ENSCAFP00000057917 ENSCAFP00000058057 ENSCAFP00000058057 LSM3-5 LSM3-5 ENSCAFP00000061016 ENSCAFP00000061016 ENSCAFP00000061498 ENSCAFP00000061498 ENSCAFP00000062765 ENSCAFP00000062765 LOC100683542 LOC100683542 ISY1 ISY1 DHX35 DHX35 SNRNP200 SNRNP200 ENSCAFP00000065931 ENSCAFP00000065931 LSM2 LSM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SF3A3Matrin-type domain-containing protein. (501 aa)
SNRPD2-2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (155 aa)
CDC5LCell division cycle 5 like. (802 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
CDC40Cell division cycle 40. (655 aa)
CWC15CWC15 spliceosome associated protein homolog. (231 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
C1H19orf54Chromosome 1 C19orf54 homolog. (337 aa)
CRNKL1Crooked neck pre-mRNA splicing factor 1. (728 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
MTREXMtr4 exosome RNA helicase. (1042 aa)
CWC27CWC27 spliceosome associated cyclophilin. (472 aa)
PPWD1Peptidylprolyl isomerase domain and WD repeat containing 1. (624 aa)
ZCCHC8Zinc finger CCHC-type containing 8. (709 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1418 aa)
PLRG1Pleiotropic regulator 1. (515 aa)
DDX23DEAD-box helicase 23. (824 aa)
BCAS2BCAS2 pre-mRNA processing factor. (225 aa)
SNRPNSmall nuclear ribonucleoprotein-associated protein. (239 aa)
SNRPA1Small nuclear ribonucleoprotein polypeptide A. (255 aa)
SF3B1Splicing factor 3b subunit 1. (1429 aa)
SNRNP40Small nuclear ribonucleoprotein U5 subunit 40. (382 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
DDX5Uncharacterized protein; Belongs to the DEAD box helicase family. (614 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa)
RBM44RNA binding motif protein 44. (1052 aa)
SF3A1Splicing factor 3a subunit 1. (793 aa)
LOC478183Uncharacterized protein. (228 aa)
SRRM1PWI domain-containing protein. (913 aa)
SF3B2Splicing factor 3b subunit 2. (895 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (784 aa)
HNRNPRHeterogeneous nuclear ribonucleoprotein R. (633 aa)
ADIPOQEukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (407 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
PNNPinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation [...] (767 aa)
EFTUD2Elongation factor Tu GTP binding domain containing 2. (1009 aa)
DHX8DEAH-box helicase 8. (1242 aa)
ESS2Ess-2 splicing factor homolog. (478 aa)
PPIL2Peptidylprolyl isomerase like 2. (523 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (805 aa)
WDR83WD repeat domain 83. (315 aa)
SLU7SLU7 homolog, splicing factor. (633 aa)
LOC100685327Uncharacterized protein. (1707 aa)
SRSF1Serine and arginine rich splicing factor 1. (253 aa)
WDR25WD repeat domain 25. (539 aa)
RBM22RNA binding motif protein 22. (420 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
RBMXRNA binding motif protein X-linked. (391 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (231 aa)
CACTINCactin, spliceosome C complex subunit. (752 aa)
PRPF8Pre-mRNA processing factor 8. (2335 aa)
LSM7Sm domain-containing protein. (103 aa)
SF3B3Splicing factor 3b subunit 3. (1217 aa)
DHX38DEAH-box helicase 38. (1226 aa)
SYF2Uncharacterized protein. (246 aa)
E2RPP3_CANLFRBM1CTR domain-containing protein. (185 aa)
SNRPB2Uncharacterized protein. (225 aa)
J9NRX2_CANLFSm domain-containing protein. (86 aa)
J9NS74_CANLFRRM domain-containing protein. (130 aa)
MAGOHBUncharacterized protein. (148 aa)
ENSCAFP00000038104annotation not available (501 aa)
DDX41DEAD-box helicase 41. (649 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (623 aa)
SNW1SNW domain containing 1. (536 aa)
C11H5orf63Glutaredoxin-like protein; Belongs to the glutaredoxin family. (119 aa)
SF3A2Splicing factor 3a subunit 2. (478 aa)
J9P7Q9_CANLFUncharacterized protein. (526 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (328 aa)
LOC100686524Uncharacterized protein. (178 aa)
SNRPD3-2Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
CWC22CWC22 spliceosome associated protein homolog. (908 aa)
J9PAH1_CANLFUncharacterized protein. (231 aa)
XAB2XPA binding protein 2. (881 aa)
J9PBG0_CANLFUncharacterized protein. (109 aa)
SNRPG-2Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
PRPF19Pre-mRNA processing factor 19. (522 aa)
LSM3-2U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
LSM3-3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
LSM3-4U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (107 aa)
FRG1FSHD region gene 1. (258 aa)
ENSCAFP00000048678Sm domain-containing protein. (98 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
GPATCH1G-patch domain containing 1. (1126 aa)
SNRPGSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (161 aa)
SRRM2Serine/arginine repetitive matrix 2. (2906 aa)
ENSCAFP00000051373RRM domain-containing protein. (86 aa)
ENSCAFP00000051873Uncharacterized protein. (199 aa)
SF3B6Splicing factor 3b subunit 6. (311 aa)
PRPF4BPre-mRNA processing factor 4B. (1026 aa)
ENSCAFP00000052764Uncharacterized protein. (148 aa)
ENSCAFP00000053603Uncharacterized protein. (96 aa)
BUD31Uncharacterized protein. (144 aa)
ENSCAFP00000054298Uncharacterized protein. (123 aa)
PRPF6Pre-mRNA processing factor 6. (971 aa)
PPIL1Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (264 aa)
ENSCAFP00000057917Sm domain-containing protein. (81 aa)
ENSCAFP00000058057Sm domain-containing protein. (70 aa)
LSM3-5U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
ENSCAFP00000061016Sm domain-containing protein. (77 aa)
ENSCAFP00000061498Sm domain-containing protein. (62 aa)
ENSCAFP00000062765RRM domain-containing protein. (88 aa)
LOC100683542Sm domain-containing protein. (94 aa)
ISY1Uncharacterized protein. (402 aa)
DHX35DEAH-box helicase 35. (701 aa)
SNRNP200Small nuclear ribonucleoprotein U5 subunit 200. (2136 aa)
ENSCAFP00000065931Uncharacterized protein. (85 aa)
LSM2Sm domain-containing protein. (311 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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