STRINGSTRING
TSKU TSKU AHI1 AHI1 FRS2 FRS2 OSR2 OSR2 CTHRC1 CTHRC1 SLC44A4 SLC44A4 RING1 RING1 ZHX2 ZHX2 BAK1 BAK1 TIFAB TIFAB NEUROG1 NEUROG1 ATF4 ATF4 AGTPBP1 AGTPBP1 PTK7 PTK7 GNGT1 GNGT1 KDR KDR DLX5 DLX5 TDRD7 TDRD7 SIX2 SIX2 KCNQ4 KCNQ4 HOXA2 HOXA2 WDPCP WDPCP WHRN WHRN ATP6V1B1 ATP6V1B1 TSPAN12 TSPAN12 GLI3 GLI3 PRDM1 PRDM1 OSR1 OSR1 INTU INTU HIPK2 HIPK2 DLL1 DLL1 VSX1 VSX1 SDK2 SDK2 SLC9A3R1 SLC9A3R1 GATA3 GATA3 INSIG1 INSIG1 SPRY2 SPRY2 DZANK1 DZANK1 RPGRIP1 RPGRIP1 JAG1 JAG1 FSCN2 FSCN2 PTPRQ PTPRQ LRIG1 LRIG1 RP1 RP1 EPHB1 EPHB1 CHD7 CHD7 GJB6 GJB6 FAT1 FAT1 MAN2A1 MAN2A1 EDNRA EDNRA PLS1 PLS1 PDE6C PDE6C HESX1 HESX1 FZD3 FZD3 CLRN1 CLRN1 CYP26B1 CYP26B1 USH1C USH1C CALB1 CALB1 COL2A1 COL2A1 NKX3-1 NKX3-1 FOXF2 FOXF2 HIPK1 HIPK1 IMPG2 IMPG2 EDN1 EDN1 ATOH1 ATOH1 RIPOR2 RIPOR2 CDON CDON CRYAA CRYAA NOTCH2 NOTCH2 ALDH1A3 ALDH1A3 GNAT1 GNAT1 LRP5 LRP5 FOXN4 FOXN4 CRB1 CRB1 SEC24B SEC24B CABP4 CABP4 NRL NRL GBX2 GBX2 PROX1 PROX1 HMX3 HMX3 GRHL3 GRHL3 SP3 SP3 STRC STRC MYPN MYPN TMIE TMIE PRKRA PRKRA FZD2 FZD2 C27H12orf57 C27H12orf57 FASLG FASLG FBN1 FBN1 PRKCI PRKCI COL5A2 COL5A2 BMP4 BMP4 NAGLU NAGLU CLRN2 CLRN2 NKX3-2 NKX3-2 OTOP1 OTOP1 MSX1 MSX1 ROM1 ROM1 MFAP2 MFAP2 CHRNA9 CHRNA9 EPHA2 EPHA2 DVL2 DVL2 WDR19 WDR19 SDK1 SDK1 MFN2 MFN2 FOXI1 FOXI1 MAPK3 MAPK3 MEGF11 MEGF11 TSHR TSHR LCTL LCTL NTN1 NTN1 TTC8 TTC8 LHX1 LHX1 TTC39C TTC39C F1PXS7_CANLF F1PXS7_CANLF ZIC3 ZIC3 DVL1 DVL1 NOTCH1 NOTCH1 GNAT2 GNAT2 GAS1 GAS1 MAPK1 MAPK1 NF2 NF2 GRXCR2 GRXCR2 RORB RORB FRZB FRZB NF1 NF1 COL8A1 COL8A1 CITED2 CITED2 SOX8 SOX8 TBX2 TBX2 FGF10 FGF10 LRRC1 LRRC1 STRA6 STRA6 LOC100855804 LOC100855804 SIX4 SIX4 COL8A2 COL8A2 BLOC1S5 BLOC1S5 GDF11 GDF11 J9NYX8_CANLF J9NYX8_CANLF OTX1 OTX1 NIPBL NIPBL SIX1 SIX1 CELSR1 CELSR1 TBC1D20 TBC1D20 RPGRIP1L RPGRIP1L THY1 THY1 PITX3 PITX3 LOC100856175 LOC100856175 TBX3 TBX3 ZEB1 ZEB1 SOBP SOBP IGSF22 IGSF22 AQP1 AQP1 TCAP TCAP HPN HPN FGF9 FGF9 THRB THRB MFAP5 MFAP5 MAPK3-2 MAPK3-2 PHACTR4 PHACTR4 EYA1 EYA1 GSC GSC MFRP MFRP ENSCAFP00000049352 ENSCAFP00000049352 LHFPL5 LHFPL5 STAT3 STAT3 FAT3 FAT3 TFAP2A TFAP2A TULP1 TULP1 SCRIB SCRIB BCAR3 BCAR3 RDH13 RDH13 ENSCAFP00000052510 ENSCAFP00000052510 WNT1 WNT1 CRB2 CRB2 INSIG2 INSIG2 EPHB2 EPHB2 PROM1 PROM1 MYO6 MYO6 BBS4 BBS4 HMX2 HMX2 PITX2 PITX2 EFEMP1 EFEMP1 KDM2B KDM2B MFSD2A MFSD2A PDZD7 PDZD7 NR2E3 NR2E3 USH1G USH1G LRIG3 LRIG3 RARG RARG NTRK2 NTRK2 KCNQ1 KCNQ1 BCR BCR DLX6 DLX6 HIF1A HIF1A LOC111095293 LOC111095293 RARB RARB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSKUTsukushi, small leucine rich proteoglycan. (396 aa)
AHI1Abelson helper integration site 1. (1178 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
CTHRC1Collagen triple helix repeat containing 1. (113 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (708 aa)
RING1E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] (406 aa)
ZHX2Zinc fingers and homeoboxes 2. (838 aa)
BAK1BCL2 antagonist/killer 1. (243 aa)
TIFABTIFA inhibitor. (162 aa)
NEUROG1Neurogenin 1. (246 aa)
ATF4Activating transcription factor 4. (350 aa)
AGTPBP1ATP/GTP binding protein 1. (1226 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
GNGT1Guanine nucleotide-binding protein G(T) subunit gamma-T1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
DLX5Distal-less homeobox 5. (289 aa)
TDRD7Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity). (1098 aa)
SIX2SIX homeobox 2. (298 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (711 aa)
HOXA2Homeobox A2. (374 aa)
WDPCPWD repeat containing planar cell polarity effector. (720 aa)
WHRNWhirlin. (938 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. (531 aa)
TSPAN12Tetraspanin. (305 aa)
GLI3GLI family zinc finger 3. (1590 aa)
PRDM1PR/SET domain 1. (822 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
INTUInturned planar cell polarity protein. (941 aa)
HIPK2Homeodomain interacting protein kinase 2. (1286 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
VSX1Visual system homeobox 1. (364 aa)
SDK2Sidekick cell adhesion molecule 2. (2120 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
GATA3GATA binding protein 3. (444 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (320 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
DZANK1Double zinc ribbon and ankyrin repeat domains 1. (778 aa)
RPGRIP1RPGR-interacting protein 1. (1209 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FSCN2Fascin. (492 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2281 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1042 aa)
RP1Oxygen-regulated protein 1; Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity). (2149 aa)
EPHB1EPH receptor B1. (984 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (428 aa)
FAT1FAT atypical cadherin 1. (4646 aa)
MAN2A1Alpha-mannosidase. (1106 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (426 aa)
PLS1Plastin 1. (629 aa)
PDE6CPhosphodiesterase. (845 aa)
HESX1HESX homeobox 1. (186 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CLRN1Clarin 1. (232 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
USH1CUSH1 protein network component harmonin. (898 aa)
CALB1Calbindin 1. (261 aa)
COL2A1Collagen type II alpha 1 chain. (1488 aa)
NKX3-1NK3 homeobox 1. (214 aa)
FOXF2Forkhead box F2. (429 aa)
HIPK1Homeodomain interacting protein kinase 1. (1298 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1234 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1066 aa)
CDONCell adhesion associated, oncogene regulated. (1235 aa)
CRYAAAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. (173 aa)
NOTCH2Notch receptor 2. (2726 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
GNAT1Guanine nucleotide-binding protein G(t) subunit alpha-1; Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream eff [...] (350 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1583 aa)
FOXN4Forkhead box N4. (523 aa)
CRB1Crumbs cell polarity complex component 1. (1433 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1272 aa)
CABP4Calcium binding protein 4. (277 aa)
NRLNeural retina leucine zipper. (257 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
PROX1Prospero homeobox 1. (737 aa)
HMX3H6 family homeobox 3. (339 aa)
GRHL3Grainyhead like transcription factor 3. (607 aa)
SP3Sp3 transcription factor. (716 aa)
STRCStereocilin. (1765 aa)
MYPNMyopalladin. (1322 aa)
TMIETransmembrane inner ear. (155 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (610 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
C27H12orf57Chromosome 27 C12orf57 homolog. (97 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (286 aa)
FBN1Uncharacterized protein. (2871 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (747 aa)
CLRN2Clarin 2. (232 aa)
NKX3-2NK3 homeobox 2. (333 aa)
OTOP1Otopetrin 1. (379 aa)
MSX1Msh homeobox 1. (276 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
MFAP2Microfibril associated protein 2. (203 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (526 aa)
EPHA2EPH receptor A2. (1121 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
WDR19WD repeat domain 19. (1182 aa)
SDK1Sidekick cell adhesion molecule 1. (2125 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
FOXI1Forkhead box I1. (378 aa)
MAPK3Mitogen-activated protein kinase. (283 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
LCTLLactase like; Belongs to the glycosyl hydrolase 1 family. (687 aa)
NTN1Netrin 1. (577 aa)
TTC8Tetratricopeptide repeat domain 8 isoform 1. (515 aa)
LHX1LIM homeobox 1. (406 aa)
TTC39CTetratricopeptide repeat domain 39C. (527 aa)
F1PXS7_CANLFProtein kinase domain-containing protein. (232 aa)
ZIC3Zic family member 3. (466 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
NOTCH1Notch receptor 1. (2565 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
GAS1Growth arrest specific 1. (385 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NF2Neurofibromin 2. (597 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (248 aa)
RORBRAR related orphan receptor B. (470 aa)
FRZBFrizzled related protein. (168 aa)
NF1Neurofibromin 1. (2784 aa)
COL8A1Collagen type VIII alpha 1 chain. (744 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (398 aa)
SOX8SRY-box 8. (462 aa)
TBX2T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). (655 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
LRRC1Leucine rich repeat containing 1. (511 aa)
STRA6Stimulated by retinoic acid 6. (647 aa)
LOC100855804Uncharacterized protein. (2797 aa)
SIX4SIX homeobox 4. (804 aa)
COL8A2Collagen type VIII alpha 2 chain. (698 aa)
BLOC1S5Biogenesis of lysosomal organelles complex 1 subunit 5. (217 aa)
GDF11Growth differentiation factor 11. (288 aa)
J9NYX8_CANLFGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
NIPBLNipped-B protein. (2804 aa)
SIX1SIX homeobox 1. (284 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2716 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
RPGRIP1LRPGRIP1 like. (1278 aa)
THY1Ig-like domain-containing protein. (161 aa)
PITX3Homeobox protein. (302 aa)
LOC100856175Uncharacterized protein. (2851 aa)
TBX3T-box transcription factor 3. (720 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
SOBPSine oculis binding protein homolog. (873 aa)
IGSF22Immunoglobulin superfamily member 22. (1342 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (373 aa)
TCAPTitin-cap. (210 aa)
HPNHepsin; Belongs to the peptidase S1 family. (615 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
THRBThyroid hormone receptor beta. (476 aa)
MFAP5Microfibril associated protein 5. (192 aa)
MAPK3-2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PHACTR4Phosphatase and actin regulator. (732 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (637 aa)
GSCGoosecoid homeobox. (466 aa)
MFRPMembrane frizzled-related protein. (585 aa)
ENSCAFP00000049352Uncharacterized protein. (90 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (305 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
FAT3FAT atypical cadherin 3. (4612 aa)
TFAP2ATranscription factor AP-2 alpha. (442 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (550 aa)
SCRIBScribble planar cell polarity protein. (1568 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (908 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa)
ENSCAFP00000052510DRBM domain-containing protein. (97 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (619 aa)
CRB2Crumbs cell polarity complex component 2. (1285 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (310 aa)
EPHB2EPH receptor B2. (1075 aa)
PROM1Prominin 1. (868 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
BBS4Ariadne RBR E3 ubiquitin protein ligase 1. (908 aa)
HMX2H6 family homeobox 2. (413 aa)
PITX2Paired like homeodomain 2. (458 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (521 aa)
KDM2BLysine demethylase 2B. (1397 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (601 aa)
PDZD7PDZ domain containing 7. (1081 aa)
NR2E3NR LBD domain-containing protein. (171 aa)
USH1GUSH1 protein network component sans. (611 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1086 aa)
RARGRetinoic acid receptor gamma. (628 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (713 aa)
BCRBCR activator of RhoGEF and GTPase. (1262 aa)
DLX6Distal-less homeobox 6. (248 aa)
HIF1AUncharacterized protein. (823 aa)
LOC111095293Uncharacterized protein. (138 aa)
RARBRetinoic acid receptor beta. (464 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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