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| | KITLG | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins. (335 aa) |
| | PIDD1 | P53-induced death domain protein 1. (948 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa) |
| | CASP8AP2 | Caspase 8 associated protein 2. (1974 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (578 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (489 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (752 aa) |
| | ENSCAFP00000062374 | IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (652 aa) |
| | BCL2L2 | Bcl-2-like protein 2; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity). (333 aa) |
| | SHISA5 | Shisa family member 5. (211 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (618 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (602 aa) |
| | ALKAL1 | RB1 inducible coiled-coil 1. (1610 aa) |
| | ENSCAFP00000058087 | IF rod domain-containing protein; Belongs to the intermediate filament family. (218 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (663 aa) |
| | BNIP3 | BCL2 interacting protein 3. (354 aa) |
| | TIMM50 | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (356 aa) |
| | NOL3 | Nucleolar protein 3. (204 aa) |
| | MLLT11 | MLLT11 transcription factor 7 cofactor. (90 aa) |
| | MAEL | Maelstrom spermatogenic transposon silencer. (469 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. (54 aa) |
| | CASP4 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (489 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (321 aa) |
| | TRADD | TNFRSF1A associated via death domain. (312 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | UBE4B | Ubiquitination factor E4B. (1368 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (690 aa) |
| | HIC1 | HIC ZBTB transcriptional repressor 1. (732 aa) |
| | STK26 | Serine/threonine kinase 26. (443 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (748 aa) |
| | ANXA6 | Annexin. (676 aa) |
| | GSKIP | GSK3B interacting protein. (137 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (926 aa) |
| | F1PKU4_CANLF | Uncharacterized protein. (78 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (611 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | PDK2 | Protein-serine/threonine kinase. (408 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | PCGF2 | Polycomb group ring finger 2. (344 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1200 aa) |
| | CD5 | CD5 molecule. (511 aa) |
| | EPHA2 | EPH receptor A2. (1121 aa) |
| | FAS | Fas cell surface death receptor. (734 aa) |
| | PPM1F | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (440 aa) |
| | CD27 | CD27 molecule. (229 aa) |
| | RNF186 | Ring finger protein 186. (232 aa) |
| | LGALS12 | Galectin. (335 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa) |
| | DAP | Uncharacterized protein. (102 aa) |
| | ENSCAFP00000055400 | Uncharacterized protein. (97 aa) |
| | FIS1 | Fission, mitochondrial 1. (166 aa) |
| | LOC100688321 | Uncharacterized protein. (404 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1385 aa) |
| | SKIL | SKI like proto-oncogene. (685 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa) |
| | BBC3 | Uncharacterized protein. (293 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (482 aa) |
| | ENSCAFP00000053603 | Uncharacterized protein. (96 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (551 aa) |
| | TM2D1 | TM2 domain containing 1. (220 aa) |
| | BCL2A1 | BCL2 related protein A1. (389 aa) |
| | FASLG | Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (286 aa) |
| | PDCD10 | Programmed cell death 10. (212 aa) |
| | NDUFA13 | NADH:ubiquinone oxidoreductase subunit A13. (144 aa) |
| | ZNF385B | Zinc finger protein 385B. (485 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1054 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | ADORA2A | Adenosine receptor A2a; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. (412 aa) |
| | IVNS1ABP | Influenza virus NS1A binding protein. (642 aa) |
| | HIP1 | Huntingtin interacting protein 1. (1036 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | ELL3 | Elongation factor for RNA polymerase II 3. (396 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | SIRT1 | Sirtuin 1. (745 aa) |
| | E2F2 | E2F transcription factor 2. (505 aa) |
| | DDX47 | DEAD-box helicase 47; Belongs to the DEAD box helicase family. (482 aa) |
| | PDK1 | Protein-serine/threonine kinase. (418 aa) |
| | DEDD | Death effector domain containing. (318 aa) |
| | DIDO1 | Death inducer-obliterator 1. (2212 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | BAG3 | BCL2 associated athanogene 3. (579 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (491 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (486 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. (350 aa) |
| | QRICH1 | Glutamine rich 1. (780 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (975 aa) |
| | DDX5 | Uncharacterized protein; Belongs to the DEAD box helicase family. (614 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | PTGIS | Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (475 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | DNM1L | Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa) |
| | NGF | Nerve growth factor; Belongs to the NGF-beta family. (240 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (349 aa) |
| | DAPL1 | Death associated protein like 1. (107 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (669 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1298 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1488 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (969 aa) |
| | SENP1 | SUMO specific peptidase 1. (690 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | HTRA2 | Protease serine 25. (458 aa) |
| | P2RX4 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa) |
| | IL7 | Interleukin 7. (155 aa) |
| | DIABLO | Diablo IAP-binding mitochondrial protein. (237 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1362 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2628 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | DELE1 | DAP3 binding cell death enhancer 1. (521 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3446 aa) |
| | RRP8 | Ribosomal RNA processing 8. (664 aa) |
| | PRKDC | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...] (4067 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1486 aa) |
| | PDX1 | Pancreatic and duodenum homeobox 1. (282 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (358 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | KRT18 | IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (149 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). (1418 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | BNIP3L | Uncharacterized protein. (204 aa) |
| | CLU | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself (By similarity). Binding to cell surface receptors triggers internalization of the chaperone-client complex and [...] (467 aa) |
| | FAIM2 | Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (292 aa) |
| | NF1 | Neurofibromin 1. (2784 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1825 aa) |
| | RHOT1 | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (720 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | MYBBP1A | MYB binding protein 1a. (1369 aa) |
| | BOK | Uncharacterized protein. (307 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa) |
| | CASP6 | Caspase 6; Belongs to the peptidase C14A family. (497 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (458 aa) |
| | NBN | Nibrin. (886 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (205 aa) |
| | J9NZL9_CANLF | Uncharacterized protein. (85 aa) |
| | YAP1 | Yes associated protein 1. (325 aa) |
| | BDKRB2 | B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (946 aa) |
| | G0S2 | G0/G1 switch 2. (95 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | J9P1D3_CANLF | Thioredoxin domain-containing protein. (72 aa) |
| | TMEM117 | Transmembrane protein 117. (508 aa) |
| | SNW1 | SNW domain containing 1. (536 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa) |
| | COA8 | Cytochrome c oxidase assembly factor 8. (197 aa) |
| | INCA1 | Inhibitor of CDK, cyclin A1 interacting protein 1. (265 aa) |
| | LOC478801 | Protein-serine/threonine kinase. (155 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1000 aa) |
| | CASP12 | Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution. (509 aa) |
| | AEN | Apoptosis enhancing nuclease. (496 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (606 aa) |
| | STK4 | Serine/threonine kinase 4. (514 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa) |
| | IFI27L2 | Uncharacterized protein. (110 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1157 aa) |
| | BCL2L11 | BCL2 like 11. (301 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (464 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (256 aa) |
| | FGFR3 | Fibroblast growth factor receptor 3. (978 aa) |
| | ZNF622 | Zinc finger protein 622. (621 aa) |
| | SORT1 | Sortilin. (967 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (637 aa) |
| | WWOX | WW domain containing oxidoreductase. (428 aa) |
| | DAXX | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] (735 aa) |
| | PML | Promyelocytic leukemia. (933 aa) |
| | BMI1 | RING-type domain-containing protein. (436 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (357 aa) |
| | ENSCAFP00000050545 | Uncharacterized protein. (74 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1033 aa) |
| | CTTN | Cortactin. (747 aa) |
| | DAB2IP | DAB2 interacting protein. (1283 aa) |
| | IFI6 | Interferon alpha inducible protein 6. (197 aa) |
| | TNFSF12 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (420 aa) |
| | ENSCAFP00000052403 | Uncharacterized protein. (91 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). (473 aa) |
| | CD28 | CD28 molecule. (246 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). (232 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1338 aa) |
| | RNF41 | Ring finger protein 41. (246 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1366 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | STK3 | Serine/threonine kinase 3. (491 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | BAG6 | BCL2 associated athanogene 6. (1167 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (228 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (243 aa) |
| | EP300 | E1A binding protein p300. (2308 aa) |
| | DAPK1 | Death associated protein kinase 1. (1430 aa) |
| | ATF4 | Activating transcription factor 4. (350 aa) |
| | TOPORS | TOP1 binding arginine/serine rich protein. (1043 aa) |
| | TMBIM7P | Uncharacterized protein. (355 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (651 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RPS9 | TCF3 fusion partner. (253 aa) |
| | GGCT | Uncharacterized protein. (188 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | INHBA | Inhibin subunit beta A. (424 aa) |
| | FOXO3 | Forkhead box O3. (671 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (180 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1286 aa) |
| | BCL3 | BCL3 transcription coactivator. (566 aa) |
| | INHBB-2 | Inhibin subunit beta B. (131 aa) |
| | GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa) |
| | DEDD2 | Death effector domain containing 2. (329 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | B9D2 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | STK25 | Protein kinase domain-containing protein. (426 aa) |
