| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAR | DDX58 | ENSCAFP00000025289 | ENSCAFP00000002634 | Adenosine deaminase RNA specific. | DExD/H-box helicase 58. | 0.601 |
| ADAR | DHX58 | ENSCAFP00000025289 | ENSCAFP00000023103 | Adenosine deaminase RNA specific. | DExH-box helicase 58. | 0.499 |
| ATF2 | IRF3 | ENSCAFP00000019690 | ENSCAFP00000005354 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. | Interferon regulatory factor 3. | 0.853 |
| CCL19 | CXCL10 | ENSCAFP00000002873 | ENSCAFP00000032015 | C-C motif chemokine. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.929 |
| CCL19 | TLR7 | ENSCAFP00000002873 | ENSCAFP00000043898 | C-C motif chemokine. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.535 |
| CHUK | IKBKE | ENSCAFP00000014093 | ENSCAFP00000054435 | Component of inhibitor of nuclear factor kappa B kinase complex. | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | 0.499 |
| CHUK | IRF3 | ENSCAFP00000014093 | ENSCAFP00000005354 | Component of inhibitor of nuclear factor kappa B kinase complex. | Interferon regulatory factor 3. | 0.581 |
| CHUK | TLR3 | ENSCAFP00000014093 | ENSCAFP00000044568 | Component of inhibitor of nuclear factor kappa B kinase complex. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.536 |
| CHUK | TLR7 | ENSCAFP00000014093 | ENSCAFP00000043898 | Component of inhibitor of nuclear factor kappa B kinase complex. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.504 |
| CXCL10 | CCL19 | ENSCAFP00000032015 | ENSCAFP00000002873 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | C-C motif chemokine. | 0.929 |
| CXCL10 | DDX58 | ENSCAFP00000032015 | ENSCAFP00000002634 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | DExD/H-box helicase 58. | 0.568 |
| CXCL10 | DHX58 | ENSCAFP00000032015 | ENSCAFP00000023103 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | DExH-box helicase 58. | 0.453 |
| CXCL10 | IFI6 | ENSCAFP00000032015 | ENSCAFP00000051805 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Interferon alpha inducible protein 6. | 0.508 |
| CXCL10 | IFNB1 | ENSCAFP00000032015 | ENSCAFP00000002410 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Interferon-beta. | 0.690 |
| CXCL10 | IL21 | ENSCAFP00000032015 | ENSCAFP00000005939 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] | 0.603 |
| CXCL10 | IRF3 | ENSCAFP00000032015 | ENSCAFP00000005354 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Interferon regulatory factor 3. | 0.752 |
| CXCL10 | TLR3 | ENSCAFP00000032015 | ENSCAFP00000044568 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.742 |
| CXCL10 | TLR7 | ENSCAFP00000032015 | ENSCAFP00000043898 | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.586 |
| DDX3X | IKBKE | ENSCAFP00000056769 | ENSCAFP00000054435 | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. | Inhibitor of nuclear factor kappa B kinase subunit epsilon. | 0.516 |
| DDX3X | LSM14A | ENSCAFP00000056769 | ENSCAFP00000010900 | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. | LSM14A mRNA processing body assembly factor. | 0.443 |