STRINGSTRING
PHB2 PHB2 ENSCAFP00000049600 ENSCAFP00000049600 IFI6 IFI6 IKBKE IKBKE DDX3X DDX3X POU2F2 POU2F2 ENSCAFP00000060641 ENSCAFP00000060641 POU2AF1 POU2AF1 HIF1A HIF1A CLPB CLPB EXT1 EXT1 IFNB1 IFNB1 DDX58 DDX58 CCL19 CCL19 GSDME GSDME IRF3 IRF3 IL21 IL21 WDFY4 WDFY4 LSM14A LSM14A TOMM70 TOMM70 CHUK CHUK RRP1B RRP1B ATF2 ATF2 DHX58 DHX58 PHB PHB ADAR ADAR SMAD3 SMAD3 S100A6 S100A6 RIOK3 RIOK3 RNF135 RNF135 FMR1 FMR1 CXCL10 CXCL10 VWCE VWCE J9P0Q7_CANLF J9P0Q7_CANLF J9P9X2_CANLF J9P9X2_CANLF TLR7 TLR7 TLR3 TLR3 ZC3H12A ZC3H12A LGALS8 LGALS8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHB2Prohibitin. (319 aa)
ENSCAFP00000049600Uncharacterized protein. (108 aa)
IFI6Interferon alpha inducible protein 6. (197 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (663 aa)
POU2F2POU domain protein. (735 aa)
ENSCAFP00000060641EF-hand domain-containing protein. (98 aa)
POU2AF1POU class 2 homeobox associating factor 1. (260 aa)
HIF1AUncharacterized protein. (823 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (713 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
IFNB1Interferon-beta. (186 aa)
DDX58DExD/H-box helicase 58. (925 aa)
CCL19C-C motif chemokine. (115 aa)
GSDMEGasdermin E. (510 aa)
IRF3Interferon regulatory factor 3. (281 aa)
IL21Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity); Bel [...] (146 aa)
WDFY4WDFY family member 4. (3187 aa)
LSM14ALSM14A mRNA processing body assembly factor. (448 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
RRP1BRibosomal RNA processing 1B. (702 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DHX58DExH-box helicase 58. (678 aa)
PHBProhibitin. (262 aa)
ADARAdenosine deaminase RNA specific. (929 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
S100A6S100 calcium binding protein A8; Belongs to the S-100 family. (191 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
RNF135Ring finger protein 135. (402 aa)
FMR1Fragile X mental retardation 1. (615 aa)
CXCL10C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] (98 aa)
VWCEVon Willebrand factor C and EGF domains. (880 aa)
J9P0Q7_CANLFProhibitin. (160 aa)
J9P9X2_CANLFProhibitin. (301 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (605 aa)
LGALS8Galectin 8. (556 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]