STRINGSTRING
SMARCA1 SMARCA1 LIG1 LIG1 MLH3 MLH3 NEIL1 NEIL1 UNG UNG ENSCAFP00000066039 ENSCAFP00000066039 TOP2B TOP2B XRCC1 XRCC1 MEIOB MEIOB RFC1 RFC1 SMC3 SMC3 ZRANB3 ZRANB3 POLG POLG ERCC2 ERCC2 ENSCAFP00000062039 ENSCAFP00000062039 PMS2 PMS2 SMARCA4 SMARCA4 CHTF18 CHTF18 NAV2 NAV2 MCM8 MCM8 ENSCAFP00000060413 ENSCAFP00000060413 PMS1 PMS1 RECQL RECQL EP400 EP400 LIG3 LIG3 CEP41 CEP41 RAD51 RAD51 ANKLE1 ANKLE1 DFFB DFFB FTO FTO ENSCAFP00000058271 ENSCAFP00000058271 XRCC6 XRCC6 RTEL1 RTEL1 BPTF BPTF DCLRE1C DCLRE1C KIAA1257 KIAA1257 ENSCAFP00000057080 ENSCAFP00000057080 RAD51B RAD51B DDX3X DDX3X DDX1 DDX1 POLE POLE MUTYH MUTYH TDP1 TDP1 RSF1 RSF1 G3BP1 G3BP1 DNASE1 DNASE1 CHD5 CHD5 ENSCAFP00000053494 ENSCAFP00000053494 AFF3 AFF3 ENSCAFP00000052780 ENSCAFP00000052780 OGG1 OGG1 APTX APTX DDX11 DDX11 SHPRH SHPRH REV3L REV3L RFC2 RFC2 MCM5 MCM5 TERF2 TERF2 RBBP4 RBBP4 TREX1 TREX1 ENSCAFP00000049065 ENSCAFP00000049065 TEP1 TEP1 TERT TERT ENSCAFP00000047314 ENSCAFP00000047314 N6AMT1 N6AMT1 CHD8 CHD8 DICER1 DICER1 POLG2 POLG2 FEN1 FEN1 TOP2A TOP2A SMARCAD1 SMARCAD1 APEX1 APEX1 MCM2 MCM2 NEIL3 NEIL3 SMC5 SMC5 FANCM FANCM SMARCA2 SMARCA2 THAP9 THAP9 MSH6 MSH6 RAD50 RAD50 ERCC6L ERCC6L HELQ HELQ CHD6 CHD6 XRCC5 XRCC5 DNASE1L2 DNASE1L2 ATAD5 ATAD5 SMUG1 SMUG1 DNASE2 DNASE2 POLN POLN MSH4 MSH4 HELB HELB DNASE2B DNASE2B HFM1 HFM1 ENDOG ENDOG MPG MPG DKC1 DKC1 DNASE1L1 DNASE1L1 NTHL1 NTHL1 TREX2 TREX2 SUB1 SUB1 ERCC4 ERCC4 METTL4 METTL4 XRCC3 XRCC3 TOP3A TOP3A RBBP8 RBBP8 DNMT1 DNMT1 C9H17orf64 C9H17orf64 BRIP1 BRIP1 RAD51C RAD51C ATRX ATRX ALKBH1 ALKBH1 SLX1A SLX1A CHD3 CHD3 SRCAP SRCAP CECR2 CECR2 EXO1 EXO1 TOP3B TOP3B CHD4 CHD4 HAUS3 HAUS3 MCM7 MCM7 UPF1 UPF1 SMARCAL1 SMARCAL1 APEX2 APEX2 SUPV3L1 SUPV3L1 DNA2 DNA2 ALKBH4 ALKBH4 RFC4 RFC4 POLA1 POLA1 REXO2 REXO2 DHX9 DHX9 MUS81 MUS81 TM4SF19 TM4SF19 BLM BLM C18H11orf80 C18H11orf80 PGBD5 PGBD5 RAE1 RAE1 ISG20 ISG20 POLQ POLQ DCLRE1A DCLRE1A ALKBH2 ALKBH2 CHD2 CHD2 CHD1L CHD1L IGHMBP2 IGHMBP2 TDP2 TDP2 FAN1 FAN1 RAD54L2 RAD54L2 POLL POLL TTF2 TTF2 TWNK TWNK CHD9 CHD9 INO80 INO80 POLK POLK WRNIP1 WRNIP1 RAD54B RAD54B TOP1 TOP1 MSH3 MSH3 DHX36 DHX36 DNTT DNTT RAD9B RAD9B DQX1 DQX1 HLTF HLTF TERF1 TERF1 NEIL2 NEIL2 RAD17 RAD17 CDK7 CDK7 PRIMPOL PRIMPOL CHD1 CHD1 SMARCA5 SMARCA5 MPHOSPH9 MPHOSPH9 TDG TDG DNASE1L3 DNASE1L3 DNMT3B DNMT3B CHD7 CHD7 ALKBH3 ALKBH3 ERCC6 ERCC6 MCM4 MCM4 WRN WRN RFC3 RFC3 PCNA PCNA LIG4 LIG4 ERCC5 ERCC5 ENDOV ENDOV POLB POLB MGME1 MGME1 RPS3 RPS3 FBH1 FBH1 MCM6 MCM6 EXOG EXOG XRCC2 XRCC2 RECQL5 RECQL5 MBD4 MBD4 MLH1 MLH1 GTF2F2 GTF2F2 ERCC3 ERCC3 ERCC1 ERCC1 RAD54L RAD54L MRE11 MRE11 DNMT3A DNMT3A RUVBL1 RUVBL1 RUVBL2 RUVBL2 GEN1 GEN1 ASCC3 ASCC3 APLF APLF POLD1 POLD1 LOC100685589 LOC100685589 MSH2 MSH2 MCM3 MCM3 POLH POLH DMC1 DMC1 ERCC6L2 ERCC6L2 TATDN1 TATDN1 MCM9 MCM9 DSCC1 DSCC1 MSH5 MSH5 POLI POLI
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1056 aa)
LIG1DNA ligase. (915 aa)
MLH3MutL homolog 3. (1619 aa)
NEIL1Nei like DNA glycosylase 1. (519 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa)
ENSCAFP00000066039Uncharacterized protein. (112 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1609 aa)
XRCC1Uncharacterized protein. (664 aa)
MEIOBMeiosis specific with OB-fold. (518 aa)
RFC1Replication factor C subunit 1. (1198 aa)
SMC3Structural maintenance of chromosomes protein. (1219 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1128 aa)
POLGDNA polymerase gamma, catalytic subunit. (1346 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (764 aa)
ENSCAFP00000062039Uncharacterized protein. (273 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (1571 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa)
CHTF18Chromosome transmission fidelity factor 18. (1107 aa)
NAV2Neuron navigator 2. (2446 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (848 aa)
ENSCAFP00000060413Uncharacterized protein. (88 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (930 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (646 aa)
EP400E1A binding protein p400. (3075 aa)
LIG3DNA ligase. (991 aa)
CEP41Centrosomal protein 41. (378 aa)
RAD51DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (668 aa)
DFFBDNA fragmentation factor subunit beta. (347 aa)
FTOAlpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating th [...] (620 aa)
ENSCAFP00000058271WD_REPEATS_REGION domain-containing protein. (409 aa)
XRCC6X-ray repair cross complementing 6. (612 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1416 aa)
BPTFBromodomain PHD finger transcription factor. (3000 aa)
DCLRE1CDNA cross-link repair 1C. (715 aa)
KIAA1257DUF4550 domain-containing protein. (1168 aa)
ENSCAFP00000057080Uncharacterized protein. (104 aa)
RAD51BRAD51 paralog B. (350 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (663 aa)
DDX1DEAD-box helicase 1. (784 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2335 aa)
MUTYHMutY DNA glycosylase. (729 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (639 aa)
RSF1Remodeling and spacing factor 1. (1434 aa)
G3BP1G3BP stress granule assembly factor 1. (461 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G- actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Deg [...] (299 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1986 aa)
ENSCAFP00000053494Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (258 aa)
AFF3DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1346 aa)
ENSCAFP00000052780Uncharacterized protein. (377 aa)
OGG18-oxoguanine DNA glycosylase. (344 aa)
APTXAprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] (355 aa)
DDX11DEAD/H-box helicase 11. (1044 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1759 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3121 aa)
RFC2Replication factor C subunit 2. (367 aa)
MCM5Minichromosome maintenance complex component 5; Belongs to the MCM family. (689 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (540 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (430 aa)
TREX1Three prime repair exonuclease 1. (373 aa)
ENSCAFP00000049065Uncharacterized protein. (90 aa)
TEP1Telomerase associated protein 1. (2632 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa)
ENSCAFP00000047314Uncharacterized protein. (153 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (214 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2625 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1950 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (554 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1541 aa)
SMARCAD1Uncharacterized protein. (998 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (460 aa)
MCM2DNA helicase; Belongs to the MCM family. (933 aa)
NEIL3Nei like DNA glycosylase 3. (604 aa)
SMC5Structural maintenance of chromosomes 5. (1106 aa)
FANCMFA complementation group M. (2047 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1574 aa)
THAP9THAP domain containing 9. (902 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa)
RAD50RAD50 double strand break repair protein. (1312 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1268 aa)
HELQHelicase, POLQ like. (1072 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2715 aa)
XRCC5X-ray repair cross complementing 5. (829 aa)
DNASE1L2Deoxyribonuclease 1 like 2. (256 aa)
ATAD5ATPase family AAA domain containing 5. (1825 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (299 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (364 aa)
POLNDNA polymerase nu. (899 aa)
MSH4MutS homolog 4. (941 aa)
HELBDNA helicase B. (1135 aa)
DNASE2BDeoxyribonuclease 2 beta. (364 aa)
HFM1Helicase for meiosis 1. (1481 aa)
ENDOGEndonuclease G. (439 aa)
MPGN-methylpurine DNA glycosylase. (266 aa)
DKC1Dyskerin pseudouridine synthase 1. (683 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (295 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (336 aa)
TREX2Three prime repair exonuclease 2. (313 aa)
SUB1SUB1 regulator of transcription. (127 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (902 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (471 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa)
RBBP8RB binding protein 8, endonuclease. (909 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1584 aa)
C9H17orf64Chromosome 9 C17orf64 homolog. (235 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1243 aa)
RAD51CRAD51 paralog C. (379 aa)
ATRXATRX chromatin remodeler. (2489 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (272 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1977 aa)
SRCAPUncharacterized protein. (3109 aa)
CECR2CECR2 histone acetyl-lysine reader. (1303 aa)
EXO1Exonuclease 1. (836 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1984 aa)
HAUS3HAUS augmin like complex subunit 3. (603 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
UPF1UPF1 RNA helicase and ATPase. (1130 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (961 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (510 aa)
SUPV3L1Suv3 like RNA helicase. (845 aa)
DNA2DNA replication helicase/nuclease 2. (1017 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (302 aa)
RFC4Replication factor C subunit 4. (363 aa)
POLA1DNA polymerase. (1467 aa)
REXO2RNA exonuclease 2. (222 aa)
DHX9DExH-box helicase 9. (1276 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
TM4SF19Uncharacterized protein. (209 aa)
BLMBLM RecQ like helicase. (1420 aa)
C18H11orf80Chromosome 18 C11orf80 homolog. (176 aa)
PGBD5PiggyBac transposable element derived 5. (458 aa)
RAE1SPO11 initiator of meiotic double stranded breaks. (396 aa)
ISG20Interferon stimulated exonuclease gene 20. (171 aa)
POLQDNA polymerase theta. (2704 aa)
DCLRE1ADNA cross-link repair 1A. (1049 aa)
ALKBH2AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (529 aa)
CHD2Chromodomain helicase DNA binding protein 2. (1827 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (883 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (1040 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (330 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1029 aa)
RAD54L2RAD54 like 2. (1467 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (625 aa)
TTF2Transcription termination factor 2. (1150 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2902 aa)
INO80INO80 complex ATPase subunit. (1560 aa)
POLKDNA polymerase kappa. (861 aa)
WRNIP1Werner helicase interacting protein 1. (445 aa)
RAD54BRAD54 homolog B. (912 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa)
MSH3MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (1058 aa)
DHX36DEAH-box helicase 36. (1122 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (427 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (719 aa)
HLTFHelicase like transcription factor. (1008 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (431 aa)
NEIL2Nei like DNA glycosylase 2. (373 aa)
RAD17RAD17 checkpoint clamp loader component. (680 aa)
CDK7Cyclin dependent kinase 7. (346 aa)
PRIMPOLPrimase and DNA directed polymerase. (581 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1711 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
MPHOSPH9M-phase phosphoprotein 9. (1182 aa)
TDGThymine DNA glycosylase. (406 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (304 aa)
DNMT3BDNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (870 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (319 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1486 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
WRNWRN RecQ like helicase. (1574 aa)
RFC3Replication factor C subunit 3. (356 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LIG4DNA ligase. (911 aa)
ERCC5Uncharacterized protein. (1627 aa)
ENDOVEndonuclease V. (461 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
MGME1Uncharacterized protein. (237 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa)
FBH1F-box DNA helicase 1. (1046 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
EXOGExo/endonuclease G. (368 aa)
XRCC2X-ray repair cross complementing 2. (279 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa)
MLH1MutL homolog 1. (757 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (779 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa)
RAD54LRAD54 like. (747 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (897 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (908 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2202 aa)
APLFAprataxin and PNKP like factor. (510 aa)
POLD1DNA polymerase. (1107 aa)
LOC100685589DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (418 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MCM3Minichromosome maintenance complex component 3; Belongs to the MCM family. (817 aa)
POLHDNA polymerase eta. (712 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
ERCC6L2ERCC excision repair 6 like 2. (713 aa)
TATDN1TatD DNase domain containing 1. (347 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (392 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (793 aa)
POLIDNA polymerase iota. (702 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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