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SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1056 aa) | ||||
LIG1 | DNA ligase. (915 aa) | ||||
MLH3 | MutL homolog 3. (1619 aa) | ||||
NEIL1 | Nei like DNA glycosylase 1. (519 aa) | ||||
UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa) | ||||
ENSCAFP00000066039 | Uncharacterized protein. (112 aa) | ||||
TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1609 aa) | ||||
XRCC1 | Uncharacterized protein. (664 aa) | ||||
MEIOB | Meiosis specific with OB-fold. (518 aa) | ||||
RFC1 | Replication factor C subunit 1. (1198 aa) | ||||
SMC3 | Structural maintenance of chromosomes protein. (1219 aa) | ||||
ZRANB3 | Zinc finger RANBP2-type containing 3. (1128 aa) | ||||
POLG | DNA polymerase gamma, catalytic subunit. (1346 aa) | ||||
ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (764 aa) | ||||
ENSCAFP00000062039 | Uncharacterized protein. (273 aa) | ||||
PMS2 | PMS1 homolog 2, mismatch repair system component. (1571 aa) | ||||
SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa) | ||||
CHTF18 | Chromosome transmission fidelity factor 18. (1107 aa) | ||||
NAV2 | Neuron navigator 2. (2446 aa) | ||||
MCM8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (848 aa) | ||||
ENSCAFP00000060413 | Uncharacterized protein. (88 aa) | ||||
PMS1 | PMS1 homolog 1, mismatch repair system component. (930 aa) | ||||
RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (646 aa) | ||||
EP400 | E1A binding protein p400. (3075 aa) | ||||
LIG3 | DNA ligase. (991 aa) | ||||
CEP41 | Centrosomal protein 41. (378 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa) | ||||
ANKLE1 | Ankyrin repeat and LEM domain containing 1. (668 aa) | ||||
DFFB | DNA fragmentation factor subunit beta. (347 aa) | ||||
FTO | Alpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating th [...] (620 aa) | ||||
ENSCAFP00000058271 | WD_REPEATS_REGION domain-containing protein. (409 aa) | ||||
XRCC6 | X-ray repair cross complementing 6. (612 aa) | ||||
RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1416 aa) | ||||
BPTF | Bromodomain PHD finger transcription factor. (3000 aa) | ||||
DCLRE1C | DNA cross-link repair 1C. (715 aa) | ||||
KIAA1257 | DUF4550 domain-containing protein. (1168 aa) | ||||
ENSCAFP00000057080 | Uncharacterized protein. (104 aa) | ||||
RAD51B | RAD51 paralog B. (350 aa) | ||||
DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (663 aa) | ||||
DDX1 | DEAD-box helicase 1. (784 aa) | ||||
POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2335 aa) | ||||
MUTYH | MutY DNA glycosylase. (729 aa) | ||||
TDP1 | Tyrosyl-DNA phosphodiesterase 1. (639 aa) | ||||
RSF1 | Remodeling and spacing factor 1. (1434 aa) | ||||
G3BP1 | G3BP stress granule assembly factor 1. (461 aa) | ||||
DNASE1 | Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G- actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Deg [...] (299 aa) | ||||
CHD5 | Chromodomain helicase DNA binding protein 5. (1986 aa) | ||||
ENSCAFP00000053494 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (258 aa) | ||||
AFF3 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1346 aa) | ||||
ENSCAFP00000052780 | Uncharacterized protein. (377 aa) | ||||
OGG1 | 8-oxoguanine DNA glycosylase. (344 aa) | ||||
APTX | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] (355 aa) | ||||
DDX11 | DEAD/H-box helicase 11. (1044 aa) | ||||
SHPRH | SNF2 histone linker PHD RING helicase. (1759 aa) | ||||
REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3121 aa) | ||||
RFC2 | Replication factor C subunit 2. (367 aa) | ||||
MCM5 | Minichromosome maintenance complex component 5; Belongs to the MCM family. (689 aa) | ||||
TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (540 aa) | ||||
RBBP4 | RB binding protein 4, chromatin remodeling factor. (430 aa) | ||||
TREX1 | Three prime repair exonuclease 1. (373 aa) | ||||
ENSCAFP00000049065 | Uncharacterized protein. (90 aa) | ||||
TEP1 | Telomerase associated protein 1. (2632 aa) | ||||
TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa) | ||||
ENSCAFP00000047314 | Uncharacterized protein. (153 aa) | ||||
N6AMT1 | N-6 adenine-specific DNA methyltransferase 1. (214 aa) | ||||
CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2625 aa) | ||||
DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1950 aa) | ||||
POLG2 | DNA polymerase gamma 2, accessory subunit. (554 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) | ||||
TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1541 aa) | ||||
SMARCAD1 | Uncharacterized protein. (998 aa) | ||||
APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (460 aa) | ||||
MCM2 | DNA helicase; Belongs to the MCM family. (933 aa) | ||||
NEIL3 | Nei like DNA glycosylase 3. (604 aa) | ||||
SMC5 | Structural maintenance of chromosomes 5. (1106 aa) | ||||
FANCM | FA complementation group M. (2047 aa) | ||||
SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1574 aa) | ||||
THAP9 | THAP domain containing 9. (902 aa) | ||||
MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa) | ||||
RAD50 | RAD50 double strand break repair protein. (1312 aa) | ||||
ERCC6L | ERCC excision repair 6 like, spindle assembly checkpoint helicase. (1268 aa) | ||||
HELQ | Helicase, POLQ like. (1072 aa) | ||||
CHD6 | Chromodomain helicase DNA binding protein 6. (2715 aa) | ||||
XRCC5 | X-ray repair cross complementing 5. (829 aa) | ||||
DNASE1L2 | Deoxyribonuclease 1 like 2. (256 aa) | ||||
ATAD5 | ATPase family AAA domain containing 5. (1825 aa) | ||||
SMUG1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. (299 aa) | ||||
DNASE2 | Deoxyribonuclease 2, lysosomal. (364 aa) | ||||
POLN | DNA polymerase nu. (899 aa) | ||||
MSH4 | MutS homolog 4. (941 aa) | ||||
HELB | DNA helicase B. (1135 aa) | ||||
DNASE2B | Deoxyribonuclease 2 beta. (364 aa) | ||||
HFM1 | Helicase for meiosis 1. (1481 aa) | ||||
ENDOG | Endonuclease G. (439 aa) | ||||
MPG | N-methylpurine DNA glycosylase. (266 aa) | ||||
DKC1 | Dyskerin pseudouridine synthase 1. (683 aa) | ||||
DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (295 aa) | ||||
NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (336 aa) | ||||
TREX2 | Three prime repair exonuclease 2. (313 aa) | ||||
SUB1 | SUB1 regulator of transcription. (127 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (902 aa) | ||||
METTL4 | Methyltransferase like 4; Belongs to the MT-A70-like family. (471 aa) | ||||
XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (909 aa) | ||||
DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1584 aa) | ||||
C9H17orf64 | Chromosome 9 C17orf64 homolog. (235 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1243 aa) | ||||
RAD51C | RAD51 paralog C. (379 aa) | ||||
ATRX | ATRX chromatin remodeler. (2489 aa) | ||||
ALKBH1 | AlkB homolog 1, histone H2A dioxygenase. (389 aa) | ||||
SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (272 aa) | ||||
CHD3 | Chromodomain helicase DNA binding protein 3. (1977 aa) | ||||
SRCAP | Uncharacterized protein. (3109 aa) | ||||
CECR2 | CECR2 histone acetyl-lysine reader. (1303 aa) | ||||
EXO1 | Exonuclease 1. (836 aa) | ||||
TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) | ||||
CHD4 | Chromodomain helicase DNA binding protein 4. (1984 aa) | ||||
HAUS3 | HAUS augmin like complex subunit 3. (603 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) | ||||
UPF1 | UPF1 RNA helicase and ATPase. (1130 aa) | ||||
SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (961 aa) | ||||
APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (510 aa) | ||||
SUPV3L1 | Suv3 like RNA helicase. (845 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1017 aa) | ||||
ALKBH4 | AlkB homolog 4, lysine demethylase. (302 aa) | ||||
RFC4 | Replication factor C subunit 4. (363 aa) | ||||
POLA1 | DNA polymerase. (1467 aa) | ||||
REXO2 | RNA exonuclease 2. (222 aa) | ||||
DHX9 | DExH-box helicase 9. (1276 aa) | ||||
MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) | ||||
TM4SF19 | Uncharacterized protein. (209 aa) | ||||
BLM | BLM RecQ like helicase. (1420 aa) | ||||
C18H11orf80 | Chromosome 18 C11orf80 homolog. (176 aa) | ||||
PGBD5 | PiggyBac transposable element derived 5. (458 aa) | ||||
RAE1 | SPO11 initiator of meiotic double stranded breaks. (396 aa) | ||||
ISG20 | Interferon stimulated exonuclease gene 20. (171 aa) | ||||
POLQ | DNA polymerase theta. (2704 aa) | ||||
DCLRE1A | DNA cross-link repair 1A. (1049 aa) | ||||
ALKBH2 | AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (529 aa) | ||||
CHD2 | Chromodomain helicase DNA binding protein 2. (1827 aa) | ||||
CHD1L | Chromodomain helicase DNA binding protein 1 like. (883 aa) | ||||
IGHMBP2 | Immunoglobulin mu DNA binding protein 2. (1040 aa) | ||||
TDP2 | Tyrosyl-DNA phosphodiesterase 2. (330 aa) | ||||
FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1029 aa) | ||||
RAD54L2 | RAD54 like 2. (1467 aa) | ||||
POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (625 aa) | ||||
TTF2 | Transcription termination factor 2. (1150 aa) | ||||
TWNK | Twinkle mtDNA helicase. (684 aa) | ||||
CHD9 | Chromodomain helicase DNA binding protein 9. (2902 aa) | ||||
INO80 | INO80 complex ATPase subunit. (1560 aa) | ||||
POLK | DNA polymerase kappa. (861 aa) | ||||
WRNIP1 | Werner helicase interacting protein 1. (445 aa) | ||||
RAD54B | RAD54 homolog B. (912 aa) | ||||
TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (770 aa) | ||||
MSH3 | MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (1058 aa) | ||||
DHX36 | DEAH-box helicase 36. (1122 aa) | ||||
DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa) | ||||
RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (427 aa) | ||||
DQX1 | DEAQ-box RNA dependent ATPase 1. (719 aa) | ||||
HLTF | Helicase like transcription factor. (1008 aa) | ||||
TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (431 aa) | ||||
NEIL2 | Nei like DNA glycosylase 2. (373 aa) | ||||
RAD17 | RAD17 checkpoint clamp loader component. (680 aa) | ||||
CDK7 | Cyclin dependent kinase 7. (346 aa) | ||||
PRIMPOL | Primase and DNA directed polymerase. (581 aa) | ||||
CHD1 | Chromodomain helicase DNA binding protein 1. (1711 aa) | ||||
SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) | ||||
MPHOSPH9 | M-phase phosphoprotein 9. (1182 aa) | ||||
TDG | Thymine DNA glycosylase. (406 aa) | ||||
DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (304 aa) | ||||
DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (870 aa) | ||||
CHD7 | Chromodomain helicase DNA binding protein 7. (2995 aa) | ||||
ALKBH3 | AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (319 aa) | ||||
ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1486 aa) | ||||
MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) | ||||
WRN | WRN RecQ like helicase. (1574 aa) | ||||
RFC3 | Replication factor C subunit 3. (356 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
LIG4 | DNA ligase. (911 aa) | ||||
ERCC5 | Uncharacterized protein. (1627 aa) | ||||
ENDOV | Endonuclease V. (461 aa) | ||||
POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) | ||||
MGME1 | Uncharacterized protein. (237 aa) | ||||
RPS3 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa) | ||||
FBH1 | F-box DNA helicase 1. (1046 aa) | ||||
MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) | ||||
EXOG | Exo/endonuclease G. (368 aa) | ||||
XRCC2 | X-ray repair cross complementing 2. (279 aa) | ||||
RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa) | ||||
MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa) | ||||
MLH1 | MutL homolog 1. (757 aa) | ||||
GTF2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa) | ||||
ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (779 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa) | ||||
RAD54L | RAD54 like. (747 aa) | ||||
MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) | ||||
DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (897 aa) | ||||
RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) | ||||
RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) | ||||
GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) | ||||
ASCC3 | Activating signal cointegrator 1 complex subunit 3. (2202 aa) | ||||
APLF | Aprataxin and PNKP like factor. (510 aa) | ||||
POLD1 | DNA polymerase. (1107 aa) | ||||
LOC100685589 | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (418 aa) | ||||
MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) | ||||
MCM3 | Minichromosome maintenance complex component 3; Belongs to the MCM family. (817 aa) | ||||
POLH | DNA polymerase eta. (712 aa) | ||||
DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) | ||||
ERCC6L2 | ERCC excision repair 6 like 2. (713 aa) | ||||
TATDN1 | TatD DNase domain containing 1. (347 aa) | ||||
MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa) | ||||
DSCC1 | DNA replication and sister chromatid cohesion 1. (392 aa) | ||||
MSH5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (793 aa) | ||||
POLI | DNA polymerase iota. (702 aa) |