STRINGSTRING
SFRP2 SFRP2 ADNP2 ADNP2 SERPINB12 SERPINB12 CCBE1 CCBE1 CTXN1 CTXN1 CBY3 CBY3 PKHD1L1 PKHD1L1 TGFBI TGFBI FREM1 FREM1 GLP1R GLP1R BAG1 BAG1 TINAG TINAG LOC100855990 LOC100855990 PGM3 PGM3 ALG11 ALG11 APOE APOE FAM107B FAM107B UCMA UCMA CRYGN CRYGN ALK ALK COL4A1 COL4A1 POSTN POSTN EPYC EPYC KERA KERA HSPA12B HSPA12B ADAMTS9 ADAMTS9 DEFB122 DEFB122 ADAMTS6 ADAMTS6 ST8SIA4 ST8SIA4 VCAN VCAN ADAMTS1 ADAMTS1 ADAMTS5 ADAMTS5 ANGPT2 ANGPT2 THBS1 THBS1 OTOG OTOG LOXL2 LOXL2 KNL1 KNL1 LOXL1 LOXL1 FMOD FMOD OPTC OPTC ZPLD1 ZPLD1 GFOD1 GFOD1 ZP4 ZP4 GPLD1 GPLD1 PCSK6 PCSK6 TGFB2 TGFB2 FBLN5 FBLN5 TECTB TECTB ADAP1 ADAP1 COL4A5 COL4A5 AMELX AMELX TECTA TECTA LOC100855471 LOC100855471 FAM126B FAM126B EMID1 EMID1 BICC1 BICC1 GPC1 GPC1 COCH COCH SNED1 SNED1 ADAMTS4 ADAMTS4 OLFML2B OLFML2B LTBP3 LTBP3 ZP3 ZP3 NCAN NCAN SPOCK2 SPOCK2 FBN1 FBN1 MYOC MYOC MFAP2 MFAP2 MMRN2 MMRN2 LOC100684659 LOC100684659 TGFB3 TGFB3 OTOA OTOA ZP2 ZP2 PMP22 PMP22 BGN BGN PAQR4 PAQR4 ADAMTSL2 ADAMTSL2 TGFBR3 TGFBR3 GFOD2 GFOD2 ADAP2 ADAP2 ASPN ASPN F1PTS4_CANLF F1PTS4_CANLF COL8A1 COL8A1 SNORC SNORC ELN ELN RWDD2A RWDD2A DEFB123 DEFB123 ADAMTSL5 ADAMTSL5 PERP PERP LTBP2 LTBP2 FBLN2 FBLN2 SFSWAP SFSWAP COL15A1 COL15A1 COL4A3 COL4A3 COL6A1 COL6A1 OLFML2A OLFML2A C10H12orf75 C10H12orf75 COL26A1 COL26A1 CLEC1A CLEC1A CXHXorf58 CXHXorf58 MFAP4 MFAP4 PAPLN PAPLN ADAMTS10 ADAMTS10 ANXA2 ANXA2 SHH SHH THBS2 THBS2 CILP CILP CRYGC CRYGC LTBP1 LTBP1 PRELP PRELP NID1 NID1 CPZ CPZ VWF VWF DSPP DSPP ABI3BP ABI3BP THBS4 THBS4 P3H2 P3H2 LAMC1 LAMC1 MMP11 MMP11 COMP COMP DEFB126 DEFB126 VWA1 VWA1 LAMA4 LAMA4 SDC1 SDC1 EFEMP1 EFEMP1 AGRN AGRN HPSE2 HPSE2 SPARC SPARC ANOS1 ANOS1 RWDD2B RWDD2B F3 F3 ENSCAFP00000063300 ENSCAFP00000063300 LTBP4 LTBP4 ENSCAFP00000064001 ENSCAFP00000064001 RARRES2 RARRES2 MATN2 MATN2 ACAN ACAN SMOC1 SMOC1 FN1 FN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP2Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. (253 aa)
ADNP2ADNP homeobox 2. (1134 aa)
SERPINB12Serpin family B member 12; Belongs to the serpin family. (423 aa)
CCBE1Collagen and calcium binding EGF domains 1. (409 aa)
CTXN1Cortexin 1. (82 aa)
CBY3Chibby family member 3. (160 aa)
PKHD1L1PKHD1 like 1. (4263 aa)
TGFBITransforming growth factor beta induced. (638 aa)
FREM1FRAS1 related extracellular matrix 1. (2183 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (437 aa)
BAG1BCL2 associated athanogene 1. (458 aa)
TINAGTubulointerstitial nephritis antigen; Belongs to the peptidase C1 family. (476 aa)
LOC100855990Uncharacterized protein. (279 aa)
PGM3Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (652 aa)
ALG11ALG11 alpha-1,2-mannosyltransferase. (667 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (336 aa)
FAM107BFamily with sequence similarity 107 member B. (307 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (138 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (186 aa)
ALKTyrosine-protein kinase receptor. (1631 aa)
COL4A1Collagen type IV alpha 1 chain. (1586 aa)
POSTNPeriostin. (836 aa)
EPYCEpiphycan. (320 aa)
KERAKeratocan. (350 aa)
HSPA12BHeat shock protein family A (Hsp70) member 12B. (739 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1930 aa)
DEFB122Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (99 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
ST8SIA4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (379 aa)
VCANVersican. (3401 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (950 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (845 aa)
ANGPT2Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). (495 aa)
THBS1Thrombospondin 1. (1456 aa)
OTOGOtogelin. (2894 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
KNL1Kinetochore scaffold 1. (2140 aa)
LOXL1Lysyl oxidase like 1. (561 aa)
FMODFibromodulin. (376 aa)
OPTCOpticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). (327 aa)
ZPLD1Zona pellucida like domain containing 1. (442 aa)
GFOD1Glucose-fructose oxidoreductase domain containing 1. (287 aa)
ZP4Zona pellucida glycoprotein 4. (562 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (842 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (913 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FBLN5Fibulin 5. (451 aa)
TECTBTectorin beta. (342 aa)
ADAP1ArfGAP with dual PH domains 1. (442 aa)
COL4A5Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1691 aa)
AMELXAmelogenin X isoform. (192 aa)
TECTATectorin alpha. (2155 aa)
LOC100855471Uncharacterized protein. (425 aa)
FAM126BFamily with sequence similarity 126 member B. (585 aa)
EMID1EMI domain containing 1. (435 aa)
BICC1BicC family RNA binding protein 1. (987 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (664 aa)
COCHCochlin. (805 aa)
SNED1Sushi, nidogen and EGF like domains 1. (1590 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (992 aa)
OLFML2BOlfactomedin like 2B. (639 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (680 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (441 aa)
NCANNeurocan. (1353 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
FBN1Uncharacterized protein. (2871 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (483 aa)
MFAP2Microfibril associated protein 2. (203 aa)
MMRN2Multimerin 2. (1264 aa)
LOC100684659ADAM_spacer1 domain-containing protein. (438 aa)
TGFB3Transforming growth factor beta 3. (457 aa)
OTOAOtoancorin. (1139 aa)
ZP2Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. (715 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
BGNBiglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (417 aa)
PAQR4Progestin and adipoQ receptor family member 4. (273 aa)
ADAMTSL2ADAMTS like 2. (955 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
GFOD2Glucose-fructose oxidoreductase domain containing 2. (385 aa)
ADAP2ArfGAP with dual PH domains 2. (387 aa)
ASPNAsporin. (372 aa)
F1PTS4_CANLFBeta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (145 aa)
COL8A1Collagen type VIII alpha 1 chain. (744 aa)
SNORCSecondary ossification center associated regulator of chondrocyte maturation. (98 aa)
ELNElastin. (527 aa)
RWDD2ARWD domain-containing protein. (292 aa)
DEFB123Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (299 aa)
ADAMTSL5ADAMTS like 5. (522 aa)
PERPP53 apoptosis effector related to PMP22. (430 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1817 aa)
FBLN2Fibulin 2. (1228 aa)
SFSWAPSplicing factor SWAP. (940 aa)
COL15A1Collagen type XV alpha 1 chain. (1477 aa)
COL4A3Collagen type IV alpha 3 chain. (1692 aa)
COL6A1Collagen type VI alpha 1 chain. (1089 aa)
OLFML2AOlfactomedin like 2A. (661 aa)
C10H12orf75Uncharacterized protein. (52 aa)
COL26A1Collagen type XXVI alpha 1 chain. (414 aa)
CLEC1AC-type lectin domain containing 7A. (283 aa)
CXHXorf58Chromosome X CXorf58 homolog. (374 aa)
MFAP4Microfibril associated protein 4. (377 aa)
PAPLNPapilin, proteoglycan like sulfated glycoprotein. (1025 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10. (1298 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. (362 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (593 aa)
THBS2Thrombospondin 2. (1170 aa)
CILPPoly [ADP-ribose] polymerase. (1505 aa)
CRYGCGamma-crystallin C; Belongs to the beta/gamma-crystallin family. (287 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1598 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (404 aa)
NID1Nidogen 1. (1262 aa)
CPZCarboxypeptidase Z. (620 aa)
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (3256 aa)
DSPPUncharacterized protein. (841 aa)
ABI3BPABI family member 3 binding protein. (1665 aa)
THBS4Thrombospondin 4. (1038 aa)
P3H2Prolyl 3-hydroxylase 2. (757 aa)
LAMC1Laminin subunit gamma 1. (1528 aa)
MMP11Matrix metallopeptidase 11. (489 aa)
COMPCartilage oligomeric matrix protein. (891 aa)
DEFB126Beta-defensin 141. (104 aa)
VWA1Von Willebrand factor A domain containing 1. (456 aa)
LAMA4Laminin subunit alpha 4. (1857 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (317 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (521 aa)
AGRNAgrin. (2063 aa)
HPSE2Heparanase 2 (inactive). (592 aa)
SPARCSecreted protein acidic and cysteine rich. (361 aa)
ANOS1Anosmin 1. (719 aa)
RWDD2BRWD domain-containing protein. (319 aa)
F3Coagulation factor III, tissue factor. (302 aa)
ENSCAFP00000063300zf-CCHC_6 domain-containing protein. (311 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1629 aa)
ENSCAFP00000064001Endostatin domain-containing protein. (243 aa)
RARRES2Retinoic acid receptor responder 2. (235 aa)
MATN2Matrilin 2. (1097 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2332 aa)
SMOC1SPARC related modular calcium binding 1. (453 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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