STRINGSTRING
SPIB SPIB ANK1 ANK1 PDLIM3 PDLIM3 ITGB1BP2 ITGB1BP2 FBXL22 FBXL22 PSEN1 PSEN1 MYL5 MYL5 PDLIM7 PDLIM7 MYH6 MYH6 LDB3 LDB3 E2QZE6_CANLF E2QZE6_CANLF MYH16 MYH16 MYOZ1 MYOZ1 MYOM2-2 MYOM2-2 SLC4A1 SLC4A1 MYL4 MYL4 LRRC2 LRRC2 MYPN MYPN SMPX SMPX MYOM3 MYOM3 ANK3 ANK3 ACTN3 ACTN3 TMOD4 TMOD4 MYOZ2 MYOZ2 SYNPO2 SYNPO2 PYROXD1 PYROXD1 OBSL1 OBSL1 MYL7 MYL7 PDLIM1 PDLIM1 ALDOA ALDOA TRIM59 TRIM59 AHNAK AHNAK SYNC SYNC NEGR1 NEGR1 ANK2 ANK2 SAMD13 SAMD13 TNNT2 TNNT2 NKX2-5 NKX2-5 LRRC39 LRRC39 MYBPHL MYBPHL MTM1 MTM1 F1PNI3_CANLF F1PNI3_CANLF LRRC30 LRRC30 TRIM32 TRIM32 ILK ILK LRRC10B LRRC10B CAPN9 CAPN9 DNAJB3 DNAJB3 XIRP2 XIRP2 GGPS1 GGPS1 ADPRH ADPRH ACTN2 ACTN2 TNNI1 TNNI1 CAPN3 CAPN3 TNNI2 TNNI2 CSRP3 CSRP3 CMYA5 CMYA5 E2R2S9_CANLF E2R2S9_CANLF ANKRD2 ANKRD2 SRI SRI PDE4DIP PDE4DIP MYL2 MYL2 ENSCAFP00000065595 ENSCAFP00000065595 MYL1 MYL1 ARHGEF25 ARHGEF25 LRRC10 LRRC10 DNAJB7 DNAJB7 EVA1C EVA1C MYBPC3 MYBPC3 CCDC102A CCDC102A FLNC FLNC LMOD2 LMOD2 FHL2 FHL2 MYH7B MYH7B TMOD1 TMOD1 SMTNL1 SMTNL1 KCTD6 KCTD6 LMOD3 LMOD3 SRGAP3 SRGAP3 KLHL40 KLHL40 HRC HRC BMP10 BMP10 FHL3 FHL3 PPP1R12C PPP1R12C TNNI3 TNNI3 CAVIN4 CAVIN4 SPHKAP SPHKAP TRIM54 TRIM54 DNAJB6 DNAJB6 PTPRD PTPRD AHNAK-2 AHNAK-2 LOC100855804 LOC100855804 MTMR12 MTMR12 C28H10orf71 C28H10orf71 IDO1 IDO1 LOC102157295 LOC102157295 LOC100856175 LOC100856175 IGSF22 IGSF22 SMN SMN TCAP TCAP TNNC1 TNNC1 ASPH ASPH MARF1 MARF1 MYOM2 MYOM2 ACTN1 ACTN1 FRG1 FRG1 ENSCAFP00000049249 ENSCAFP00000049249 C18H7orf57 C18H7orf57 CASQ2 CASQ2 ENSCAFP00000051866 ENSCAFP00000051866 NEBL NEBL MYOT MYOT PPP1R12B PPP1R12B DES DES PRRC2B PRRC2B ROBO2 ROBO2 CHORDC1 CHORDC1 MYOM1 MYOM1 UNC45B UNC45B MYOZ3 MYOZ3 ASB2 ASB2 MYH2 MYH2 IGDCC3 IGDCC3 TMOD2 TMOD2 NEXN NEXN ROBO1 ROBO1 MYBPC1 MYBPC1 TEKT1 TEKT1 KY KY ENSCAFP00000058174 ENSCAFP00000058174 ADPRHL1 ADPRHL1 ENSCAFP00000057453 ENSCAFP00000057453 TRIM13 TRIM13 SYNM SYNM MYL3 MYL3 ENSCAFP00000057067 ENSCAFP00000057067 PPP1R12A PPP1R12A TRIM63 TRIM63 MYL10 MYL10 TNNT3 TNNT3 MYZAP MYZAP TNNT1 TNNT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPIBMyosin binding protein C, fast type. (1301 aa)
ANK1Ankyrin 1. (1954 aa)
PDLIM3PDZ and LIM domain 3. (405 aa)
ITGB1BP2Integrin subunit beta 1 binding protein 2. (347 aa)
FBXL22Uncharacterized protein. (223 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (466 aa)
MYL5Myosin light chain 5. (289 aa)
PDLIM7PDZ domain-containing protein. (269 aa)
MYH6Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
LDB3LIM domain binding 3. (780 aa)
E2QZE6_CANLFJ domain-containing protein. (70 aa)
MYH16Myosin-16; May play a role in masticatory muscles contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1945 aa)
MYOZ1Calsarcin 2. (297 aa)
MYOM2-2Ig-like domain-containing protein. (623 aa)
SLC4A1Anion exchange protein. (930 aa)
MYL4Myosin light chain 4. (299 aa)
LRRC2Leucine rich repeat containing 2. (371 aa)
MYPNMyopalladin. (1322 aa)
SMPXSmall muscle protein X-linked. (88 aa)
MYOM3Myomesin 3. (1449 aa)
ANK3Ankyrin 3. (4380 aa)
ACTN3Actinin alpha 3. (1061 aa)
TMOD4Tropomodulin 4. (345 aa)
MYOZ2Myozenin 2. (264 aa)
SYNPO2Synaptopodin 2. (1262 aa)
PYROXD1Pyridine nucleotide-disulphide oxidoreductase domain 1. (483 aa)
OBSL1Obscurin like 1. (1924 aa)
MYL7Uncharacterized protein. (203 aa)
PDLIM1PDZ and LIM domain 1. (317 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa)
TRIM59Tripartite motif containing 59. (404 aa)
AHNAKAHNAK nucleoprotein. (1973 aa)
SYNCSyncoilin, intermediate filament protein; Belongs to the intermediate filament family. (472 aa)
NEGR1Neuronal growth regulator 1. (415 aa)
ANK2Ankyrin 2. (3953 aa)
SAMD13J domain-containing protein. (222 aa)
TNNT2Troponin T2, cardiac type. (296 aa)
NKX2-5Transcription factor NKX2.5. (322 aa)
LRRC39Leucine rich repeat containing 39. (335 aa)
MYBPHLMyosin binding protein H like. (406 aa)
MTM1Myotubularin 1. (654 aa)
F1PNI3_CANLFUncharacterized protein. (336 aa)
LRRC30Leucine rich repeat containing 30. (301 aa)
TRIM32Tripartite motif containing 32. (655 aa)
ILKIntegrin linked kinase. (452 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (692 aa)
DNAJB3J domain-containing protein. (238 aa)
XIRP2Xin actin binding repeat containing 2. (3291 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
ACTN2Actinin alpha 2. (894 aa)
TNNI1Troponin I1, slow skeletal type. (270 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
TNNI2Troponin I2, fast skeletal type. (182 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
CMYA5Cardiomyopathy associated 5. (3821 aa)
E2R2S9_CANLFPDZ domain-containing protein. (257 aa)
ANKRD2Ankyrin repeat domain 2. (360 aa)
SRISorcin. (348 aa)
PDE4DIPPhosphodiesterase 4D interacting protein. (2632 aa)
MYL2Myosin light chain 2. (175 aa)
ENSCAFP00000065595Ig-like domain-containing protein. (160 aa)
MYL1Myosin light chain 1. (232 aa)
ARHGEF25Rho guanine nucleotide exchange factor 25. (619 aa)
LRRC10Leucine rich repeat containing 10. (279 aa)
DNAJB7DnaJ heat shock protein family (Hsp40) member B7. (309 aa)
EVA1CEva-1 homolog C. (441 aa)
MYBPC3Myosin binding protein C, cardiac. (1293 aa)
CCDC102ACoiled-coil domain containing 102A. (535 aa)
FLNCFilamin C. (2720 aa)
LMOD2Leiomodin 2. (158 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MYH7BMyosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1844 aa)
TMOD1Tropomodulin 1. (359 aa)
SMTNL1Smoothelin like 1. (498 aa)
KCTD6Potassium channel tetramerization domain containing 6. (237 aa)
LMOD3Leiomodin 3. (620 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
KLHL40Kelch like family member 40. (625 aa)
HRCHistidine rich calcium binding protein. (763 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FHL3Four and a half LIM domains 3. (290 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (758 aa)
TNNI3Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (211 aa)
CAVIN4Caveolae associated protein 4. (361 aa)
SPHKAPSPHK1 interactor, AKAP domain containing. (1737 aa)
TRIM54Tripartite motif containing 54. (429 aa)
DNAJB6DnaJ heat shock protein family (Hsp40) member B6. (336 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1923 aa)
AHNAK-2PDZ domain-containing protein. (185 aa)
LOC100855804Uncharacterized protein. (2797 aa)
MTMR12Myotubularin related protein 12. (732 aa)
C28H10orf71Chromosome 28 C10orf71 homolog. (1423 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (421 aa)
LOC102157295Uncharacterized protein. (184 aa)
LOC100856175Uncharacterized protein. (2851 aa)
IGSF22Immunoglobulin superfamily member 22. (1342 aa)
SMNSurvival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...] (323 aa)
TCAPTitin-cap. (210 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (303 aa)
ASPHAspartate beta-hydroxylase. (831 aa)
MARF1Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
MYOM2Uncharacterized protein. (1022 aa)
ACTN1Actinin alpha 1. (956 aa)
FRG1FSHD region gene 1. (258 aa)
ENSCAFP00000049249Uncharacterized protein. (234 aa)
C18H7orf57Chromosome 18 C7orf57 homolog. (432 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (554 aa)
ENSCAFP00000051866Uncharacterized protein. (865 aa)
NEBLNebulette. (1017 aa)
MYOTMyotilin. (804 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1059 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] (644 aa)
PRRC2BProline rich coiled-coil 2B. (2235 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (510 aa)
MYOM1Myomesin 1. (1724 aa)
UNC45BUnc-45 myosin chaperone B. (945 aa)
MYOZ3Myozenin 3. (254 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
MYH2Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1940 aa)
IGDCC3Immunoglobulin superfamily DCC subclass member 3. (767 aa)
TMOD2Tropomodulin 2. (356 aa)
NEXNNexilin F-actin binding protein. (881 aa)
ROBO1Roundabout guidance receptor 1. (1691 aa)
MYBPC1Myosin binding protein C, slow type. (1203 aa)
TEKT1Tektin-1. (504 aa)
KYKyphoscoliosis peptidase. (722 aa)
ENSCAFP00000058174Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (338 aa)
ADPRHL1Uncharacterized protein. (352 aa)
ENSCAFP00000057453PDZ domain-containing protein. (221 aa)
TRIM13Tripartite motif containing 13. (455 aa)
SYNMSynemin; Belongs to the intermediate filament family. (1280 aa)
MYL3Myosin light chain 3. (308 aa)
ENSCAFP00000057067Myotubularin phosphatase domain-containing protein. (544 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1084 aa)
TRIM63Tripartite motif containing 63. (414 aa)
MYL10Myosin light chain 10. (187 aa)
TNNT3Troponin T3, fast skeletal type. (340 aa)
MYZAPUncharacterized protein. (765 aa)
TNNT1Troponin T1, slow skeletal type. (328 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (32%) [HD]