(30 nodes) Precatalytic spliceosome network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	UBE2J1	Ubiquitin conjugating enzyme E2 J1. (313 aa)
	SNIP1	Smad nuclear interacting protein 1. (397 aa)
	PRPF38A	Pre-mRNA processing factor 38A. (312 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
	WBP4	WW domain binding protein 4. (371 aa)
	IK	IK cytokine. (547 aa)
	ZMAT2	Zinc finger matrin-type 2. (199 aa)
	CWC27	CWC27 spliceosome associated cyclophilin. (472 aa)
	SNRPA1	Small nuclear ribonucleoprotein polypeptide A. (255 aa)
	SF3A1	Splicing factor 3a subunit 1. (793 aa)
	MFAP1	Microfibril associated protein 1. (439 aa)
	SNRPG-2	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
	SF3A2	Splicing factor 3a subunit 2. (478 aa)
	RNF113A	Uncharacterized protein. (348 aa)
	RBMX2	RNA binding motif protein X-linked 2. (341 aa)
	ENSCAFP00000051873	Uncharacterized protein. (199 aa)
	SRRM2	Serine/arginine repetitive matrix 2. (2906 aa)
	SNRPG	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (161 aa)
	MTHFSD	Methenyltetrahydrofolate synthetase domain containing. (198 aa)
	E2RGA7_CANLF	Uncharacterized protein. (343 aa)
	SF3B5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
	ENSCAFP00000057191	Uncharacterized protein. (53 aa)
	SRRM3	Serine/arginine repetitive matrix 3. (395 aa)
	TXNL4A	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
	DHX16	DEAH-box helicase 16. (1042 aa)
	SNRPD2-2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (155 aa)
	SMU1	SMU1 DNA replication regulator and spliceosomal factor. (513 aa)
	SNRNP200	Small nuclear ribonucleoprotein U5 subunit 200. (2136 aa)
	MTHFSD-2	Uncharacterized protein. (63 aa)
	ENSCAFP00000058057	Sm domain-containing protein. (70 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CWC27	DHX16	ENSCAFP00000010836	ENSCAFP00000000629	CWC27 spliceosome associated cyclophilin.	DEAH-box helicase 16.	0.984
CWC27	E2RGA7_CANLF	ENSCAFP00000010836	ENSCAFP00000034071	CWC27 spliceosome associated cyclophilin.	Uncharacterized protein.	0.832
CWC27	ENSCAFP00000051873	ENSCAFP00000010836	ENSCAFP00000051873	CWC27 spliceosome associated cyclophilin.	Uncharacterized protein.	0.780
CWC27	ENSCAFP00000058057	ENSCAFP00000010836	ENSCAFP00000058057	CWC27 spliceosome associated cyclophilin.	Sm domain-containing protein.	0.662
CWC27	IK	ENSCAFP00000010836	ENSCAFP00000008794	CWC27 spliceosome associated cyclophilin.	IK cytokine.	0.435
CWC27	MFAP1	ENSCAFP00000010836	ENSCAFP00000019763	CWC27 spliceosome associated cyclophilin.	Microfibril associated protein 1.	0.836
CWC27	RBMX2	ENSCAFP00000010836	ENSCAFP00000027683	CWC27 spliceosome associated cyclophilin.	RNA binding motif protein X-linked 2.	0.920
CWC27	RNF113A	ENSCAFP00000010836	ENSCAFP00000027214	CWC27 spliceosome associated cyclophilin.	Uncharacterized protein.	0.965
CWC27	SF3A1	ENSCAFP00000010836	ENSCAFP00000018619	CWC27 spliceosome associated cyclophilin.	Splicing factor 3a subunit 1.	0.890
CWC27	SF3A2	ENSCAFP00000010836	ENSCAFP00000041224	CWC27 spliceosome associated cyclophilin.	Splicing factor 3a subunit 2.	0.892
CWC27	SF3B5	ENSCAFP00000010836	ENSCAFP00000035966	CWC27 spliceosome associated cyclophilin.	Splicing factor 3B subunit 5; Belongs to the SF3B5 family.	0.867
CWC27	SNIP1	ENSCAFP00000010836	ENSCAFP00000004890	CWC27 spliceosome associated cyclophilin.	Smad nuclear interacting protein 1.	0.921
CWC27	SNRNP200	ENSCAFP00000010836	ENSCAFP00000065424	CWC27 spliceosome associated cyclophilin.	Small nuclear ribonucleoprotein U5 subunit 200.	0.976
CWC27	SNRPA1	ENSCAFP00000010836	ENSCAFP00000015542	CWC27 spliceosome associated cyclophilin.	Small nuclear ribonucleoprotein polypeptide A.	0.780
CWC27	SNRPD2	ENSCAFP00000010836	ENSCAFP00000006557	CWC27 spliceosome associated cyclophilin.	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.	0.734
CWC27	SNRPD2-2	ENSCAFP00000010836	ENSCAFP00000000897	CWC27 spliceosome associated cyclophilin.	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.	0.734
CWC27	SNRPG	ENSCAFP00000010836	ENSCAFP00000050336	CWC27 spliceosome associated cyclophilin.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.662
CWC27	SNRPG-2	ENSCAFP00000010836	ENSCAFP00000044334	CWC27 spliceosome associated cyclophilin.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.662
CWC27	SRRM2	ENSCAFP00000010836	ENSCAFP00000050904	CWC27 spliceosome associated cyclophilin.	Serine/arginine repetitive matrix 2.	0.759
CWC27	SRRM3	ENSCAFP00000010836	ENSCAFP00000036664	CWC27 spliceosome associated cyclophilin.	Serine/arginine repetitive matrix 3.	0.759