(44 nodes) Site of DNA damage network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	WDR76	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (634 aa)
	CGAS	Cyclic GMP-AMP synthase. (501 aa)
	IFFO1	Intermediate filament family orphan 1; Belongs to the intermediate filament family. (572 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (589 aa)
	FAM178B	Family with sequence similarity 178 member B. (364 aa)
	PARP2	Poly [ADP-ribose] polymerase. (602 aa)
	SLFN5	Uncharacterized protein. (130 aa)
	IFFO2	Intermediate filament family orphan 2; Belongs to the intermediate filament family. (548 aa)
	PHF1	PHD finger protein 1. (535 aa)
	RNF168	Ring finger protein 168. (585 aa)
	PARP9	Poly(ADP-ribose) polymerase family member 9. (1030 aa)
	SHLD2	Shieldin complex subunit 2. (913 aa)
	SHLD1	Shieldin complex subunit 1. (259 aa)
	SMARCAD1	Uncharacterized protein. (998 aa)
	HELQ	Helicase, POLQ like. (1072 aa)
	RFWD3	Ring finger and WD repeat domain 3. (810 aa)
	ADPRHL2	ADP-ribosylhydrolase like 2. (520 aa)
	HELB	DNA helicase B. (1135 aa)
	WDR70	WD repeat domain 70. (654 aa)
	SLFN14	Schlafen family member 14. (957 aa)
	RNF138	Ring finger protein 138. (411 aa)
	INTS3	Integrator complex subunit 3. (956 aa)
	EXD2	Exonuclease 3'-5' domain containing 2. (717 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
	HROB	Chromosome 9 C17orf53 homolog. (629 aa)
	AUNIP	Aurora kinase A and ninein interacting protein. (368 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1936 aa)
	TRAIP	TRAF interacting protein. (469 aa)
	PARP3	Poly [ADP-ribose] polymerase. (531 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (625 aa)
	SLF2	SMC5-SMC6 complex localization factor 2. (1170 aa)
	DDB2	Damage specific DNA binding protein 2. (427 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (956 aa)
	HPF1	Histone PARylation factor 1. (345 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1486 aa)
	SETMAR	Uncharacterized protein. (318 aa)
	RNF169	Ring finger protein 169. (712 aa)
	KDM4D	Lysine demethylase 4D. (680 aa)
	UFL1	UFM1 specific ligase 1. (791 aa)
	APLF	Aprataxin and PNKP like factor. (510 aa)
	CYREN	Cell cycle regulator of NHEJ. (147 aa)
	TONSL	Tonsoku like, DNA repair protein. (1354 aa)
	OARD1	O-acyl-ADP-ribose deacylase 1. (152 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	CYREN	ENSCAFP00000004843	ENSCAFP00000004743	Aprataxin and PNKP like factor.	Cell cycle regulator of NHEJ.	0.499
APLF	PARP1	ENSCAFP00000004843	ENSCAFP00000023715	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.787
APLF	PARP2	ENSCAFP00000004843	ENSCAFP00000059353	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase.	0.772
APLF	PARP3	ENSCAFP00000004843	ENSCAFP00000014771	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase.	0.873
APLF	PARP9	ENSCAFP00000004843	ENSCAFP00000051716	Aprataxin and PNKP like factor.	Poly(ADP-ribose) polymerase family member 9.	0.507
APLF	PNKP	ENSCAFP00000004843	ENSCAFP00000061144	Aprataxin and PNKP like factor.	Polynucleotide kinase 3'-phosphatase.	0.563
APLF	POLL	ENSCAFP00000004843	ENSCAFP00000014568	Aprataxin and PNKP like factor.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.501
APLF	RNF138	ENSCAFP00000004843	ENSCAFP00000026619	Aprataxin and PNKP like factor.	Ring finger protein 138.	0.574
AUNIP	CYREN	ENSCAFP00000018756	ENSCAFP00000004743	Aurora kinase A and ninein interacting protein.	Cell cycle regulator of NHEJ.	0.489
CGAS	SAMHD1	ENSCAFP00000066308	ENSCAFP00000012710	Cyclic GMP-AMP synthase.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.565
CYREN	APLF	ENSCAFP00000004743	ENSCAFP00000004843	Cell cycle regulator of NHEJ.	Aprataxin and PNKP like factor.	0.499
CYREN	AUNIP	ENSCAFP00000004743	ENSCAFP00000018756	Cell cycle regulator of NHEJ.	Aurora kinase A and ninein interacting protein.	0.489
CYREN	SHLD1	ENSCAFP00000004743	ENSCAFP00000051507	Cell cycle regulator of NHEJ.	Shieldin complex subunit 1.	0.499
DDB2	ERCC6	ENSCAFP00000013004	ENSCAFP00000009895	Damage specific DNA binding protein 2.	ERCC excision repair 6, chromatin remodeling factor.	0.584
DDB2	PARP1	ENSCAFP00000013004	ENSCAFP00000023715	Damage specific DNA binding protein 2.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.761
DDB2	PARP2	ENSCAFP00000013004	ENSCAFP00000059353	Damage specific DNA binding protein 2.	Poly [ADP-ribose] polymerase.	0.616
ERCC6	DDB2	ENSCAFP00000009895	ENSCAFP00000013004	ERCC excision repair 6, chromatin remodeling factor.	Damage specific DNA binding protein 2.	0.584
ERCC6	PARP2	ENSCAFP00000009895	ENSCAFP00000059353	ERCC excision repair 6, chromatin remodeling factor.	Poly [ADP-ribose] polymerase.	0.408
ERCC6	SMARCAD1	ENSCAFP00000009895	ENSCAFP00000042662	ERCC excision repair 6, chromatin remodeling factor.	Uncharacterized protein.	0.416
FAM178B	KDM4D	ENSCAFP00000059986	ENSCAFP00000006122	Family with sequence similarity 178 member B.	Lysine demethylase 4D.	0.454