node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADD1 | ADD2 | ENSCAFP00000065621 | ENSCAFP00000005087 | Adducin 1. | Adducin 2. | 0.963 |
ADD1 | ADD3 | ENSCAFP00000065621 | ENSCAFP00000015741 | Adducin 1. | Adducin 3. | 0.949 |
ADD2 | ADD1 | ENSCAFP00000005087 | ENSCAFP00000065621 | Adducin 2. | Adducin 1. | 0.963 |
ADD2 | REN | ENSCAFP00000005087 | ENSCAFP00000061818 | Adducin 2. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.438 |
ADD3 | ADD1 | ENSCAFP00000015741 | ENSCAFP00000065621 | Adducin 3. | Adducin 1. | 0.949 |
ADD3 | REN | ENSCAFP00000015741 | ENSCAFP00000061818 | Adducin 3. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.438 |
EDN1 | NPPA | ENSCAFP00000014389 | ENSCAFP00000053231 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. | 0.803 |
EDN1 | REN | ENSCAFP00000014389 | ENSCAFP00000061818 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.874 |
EDN1 | SRC | ENSCAFP00000014389 | ENSCAFP00000044994 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Tyrosine-protein kinase. | 0.438 |
EGFR | SRC | ENSCAFP00000005164 | ENSCAFP00000044994 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.989 |
NPPA | EDN1 | ENSCAFP00000053231 | ENSCAFP00000014389 | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.803 |
NPPA | REN | ENSCAFP00000053231 | ENSCAFP00000061818 | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.876 |
REN | ADD2 | ENSCAFP00000061818 | ENSCAFP00000005087 | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | Adducin 2. | 0.438 |
REN | ADD3 | ENSCAFP00000061818 | ENSCAFP00000015741 | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | Adducin 3. | 0.438 |
REN | EDN1 | ENSCAFP00000061818 | ENSCAFP00000014389 | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.874 |
REN | NPPA | ENSCAFP00000061818 | ENSCAFP00000053231 | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. | 0.876 |
SRC | EDN1 | ENSCAFP00000044994 | ENSCAFP00000014389 | Tyrosine-protein kinase. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.438 |
SRC | EGFR | ENSCAFP00000044994 | ENSCAFP00000005164 | Tyrosine-protein kinase. | Receptor protein-tyrosine kinase. | 0.989 |