(9 nodes) (2011) Molecular characterisation of Toll-like receptors in the black flying fox Pteropus alecto. network (Canis lupus familiaris)

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Your Input:
	IFNB1	Interferon-beta. (186 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
	TLR10	Toll like receptor 10; Belongs to the Toll-like receptor family. (807 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	TLR1	Toll like receptor 1; Belongs to the Toll-like receptor family. (760 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1121 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (652 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	IFNB1	ENSCAFP00000063394	ENSCAFP00000002410	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Interferon-beta.	0.692
CD4	TLR1	ENSCAFP00000063394	ENSCAFP00000032660	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.701
CD4	TLR2	ENSCAFP00000063394	ENSCAFP00000012269	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.809
CD4	TLR3	ENSCAFP00000063394	ENSCAFP00000044568	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.760
CD4	TLR4	ENSCAFP00000063394	ENSCAFP00000031395	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.836
CD4	TLR7	ENSCAFP00000063394	ENSCAFP00000043898	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.786
IFNB1	CD4	ENSCAFP00000002410	ENSCAFP00000063394	Interferon-beta.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.692
IFNB1	TLR1	ENSCAFP00000002410	ENSCAFP00000032660	Interferon-beta.	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.536
IFNB1	TLR2	ENSCAFP00000002410	ENSCAFP00000012269	Interferon-beta.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.636
IFNB1	TLR3	ENSCAFP00000002410	ENSCAFP00000044568	Interferon-beta.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.877
IFNB1	TLR4	ENSCAFP00000002410	ENSCAFP00000031395	Interferon-beta.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.637
IFNB1	TLR7	ENSCAFP00000002410	ENSCAFP00000043898	Interferon-beta.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.677
TLR1	CD4	ENSCAFP00000032660	ENSCAFP00000063394	Toll like receptor 1; Belongs to the Toll-like receptor family.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.701
TLR1	IFNB1	ENSCAFP00000032660	ENSCAFP00000002410	Toll like receptor 1; Belongs to the Toll-like receptor family.	Interferon-beta.	0.536
TLR1	TLR2	ENSCAFP00000032660	ENSCAFP00000012269	Toll like receptor 1; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.994
TLR1	TLR3	ENSCAFP00000032660	ENSCAFP00000044568	Toll like receptor 1; Belongs to the Toll-like receptor family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.500
TLR1	TLR4	ENSCAFP00000032660	ENSCAFP00000031395	Toll like receptor 1; Belongs to the Toll-like receptor family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.455
TLR1	TLR7	ENSCAFP00000032660	ENSCAFP00000043898	Toll like receptor 1; Belongs to the Toll-like receptor family.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.594
TLR1	UNC93B1	ENSCAFP00000032660	ENSCAFP00000045931	Toll like receptor 1; Belongs to the Toll-like receptor family.	Unc-93 homolog B1, TLR signaling regulator.	0.525
TLR10	TLR2	ENSCAFP00000023840	ENSCAFP00000012269	Toll like receptor 10; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.721