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NR3C1 NR3C1 F1PIN6_CANLF F1PIN6_CANLF PGR PGR IKZF1 IKZF1 CALM2 CALM2 SRF SRF LOC477441 LOC477441 J9P1C6_CANLF J9P1C6_CANLF LOC106558049 LOC106558049 LOC106560188 LOC106560188 LOC100688969 LOC100688969 LOC106558132 LOC106558132 NFATC1 NFATC1 PRKACB PRKACB CALML6 CALML6 CAPS CAPS LOC100683724 LOC100683724 CALML4 CALML4 GAPDH GAPDH CEBPA CEBPA PAX8 PAX8 GAPDHS GAPDHS CALML5 CALML5 ENSCAFP00000062462 ENSCAFP00000062462 PRKAR2B PRKAR2B PRKACA PRKACA AHR AHR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR3C1Nuclear receptor subfamily 3 group C member 1. (781 aa)
F1PIN6_CANLFUncharacterized protein; Belongs to the calmodulin family. (364 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. (939 aa)
IKZF1IKAROS family zinc finger 1. (684 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
SRFSerum response factor. (508 aa)
LOC477441Glyceraldehyde-3-phosphate dehydrogenase. (334 aa)
J9P1C6_CANLFGlyceraldehyde-3-phosphate dehydrogenase. (332 aa)
LOC106558049Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
LOC106560188Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (358 aa)
LOC100688969Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
LOC106558132Glyceraldehyde-3-phosphate dehydrogenase. (368 aa)
NFATC1Nuclear factor of activated T cells 1. (923 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CALML6Calmodulin like 6. (156 aa)
CAPSCalcyphosin; Calcium-binding protein. May play a role in cellular signaling events (Potential). (189 aa)
LOC100683724Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CALML4Calmodulin like 4. (120 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CEBPABZIP domain-containing protein. (159 aa)
PAX8Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development. (484 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (404 aa)
CALML5Calmodulin like 5. (169 aa)
ENSCAFP00000062462Glyceraldehyde-3-phosphate dehydrogenase. (338 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (427 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
AHRAryl hydrocarbon receptor. (853 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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