STRINGSTRING
MAML1 MAML1 MAML3 MAML3 FGF21 FGF21 DLL1 DLL1 JAG1 JAG1 FGF14 FGF14 FGF20 FGF20 DLL4 DLL4 GLB1L2 GLB1L2 GLB1L3 GLB1L3 NOTCH2 NOTCH2 FGF3 FGF3 FGF19 FGF19 GAPDH GAPDH NOTCH3 NOTCH3 FGF22 FGF22 FGF1 FGF1 FGF11 FGF11 FGF10 FGF10 FGF12 FGF12 FGF4 FGF4 FGF16 FGF16 LOC607396 LOC607396 FGF6 FGF6 FGF9 FGF9 GLB1 GLB1 FGF17 FGF17 RBPJ RBPJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAML1Mastermind like transcriptional coactivator 1. (1011 aa)
MAML3Mastermind like transcriptional coactivator 3. (1098 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (732 aa)
GLB1L2Beta-galactosidase. (636 aa)
GLB1L3Beta-galactosidase. (603 aa)
NOTCH2Notch receptor 2. (2726 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
NOTCH3Notch receptor 3. (2148 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC607396Beta-galactosidase. (733 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
GLB1Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (946 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (513 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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