STRINGSTRING
EP300 EP300 RARB RARB MECOM MECOM NR2F1 NR2F1 TP53 TP53 SLC2A4 SLC2A4 PPARA PPARA PPARD PPARD INS INS EIF4E EIF4E RXRG RXRG PPARGC1A PPARGC1A CDKN1A CDKN1A STAT1 STAT1 TERT TERT TEAD4 TEAD4 PHOX2A PHOX2A TCF7L2 TCF7L2 PRKAB2 PRKAB2 J9NYJ5_CANLF J9NYJ5_CANLF KCNJ11 KCNJ11 USF2 USF2 ESR1 ESR1 STK11 STK11 PRKAA2 PRKAA2 TGIF1 TGIF1 RPS6KB1 RPS6KB1 SMAD3 SMAD3 MTOR MTOR ERBB2 ERBB2 POU2F1 POU2F1 SELE SELE ZBTB16 ZBTB16 SP3 SP3 PRKCA PRKCA NR1I2 NR1I2 TGFB2 TGFB2 ITGB6 ITGB6 HNF4G HNF4G ARNTL ARNTL TCF7L1 TCF7L1 SP1 SP1 CDX2 CDX2 COL4A2 COL4A2 COL4A1 COL4A1 FOXA2 FOXA2 PPARG PPARG PRKAG2 PRKAG2 NCOA1 NCOA1 ITGB1 ITGB1 GLI3 GLI3 TGFA TGFA SLC2A1 SLC2A1 SND1 SND1 LEP LEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EP300E1A binding protein p300. (2308 aa)
RARBRetinoic acid receptor beta. (464 aa)
MECOMMDS1 and EVI1 complex locus. (1239 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (421 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (553 aa)
PPARAPeroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (568 aa)
PPARDPeroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). (473 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (232 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
RXRGRetinoid X receptor gamma. (538 aa)
PPARGC1APPARG coactivator 1 alpha. (891 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (357 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (480 aa)
PHOX2APaired like homeobox 2A. (298 aa)
TCF7L2Transcription factor 7 like 2. (565 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
J9NYJ5_CANLFHomeobox_KN domain-containing protein. (91 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
USF2Upstream transcription factor 2, c-fos interacting. (319 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
PRKAA2Non-specific serine/threonine protein kinase. (532 aa)
TGIF1TGFB induced factor homeobox 1. (272 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)
ERBB2Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] (1263 aa)
POU2F1POU domain protein. (767 aa)
SELEE-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. (616 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
SP3Sp3 transcription factor. (716 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (471 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (880 aa)
HNF4GHepatocyte nuclear factor 4 gamma. (509 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (634 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
SP1Sp1 transcription factor. (782 aa)
CDX2Caudal type homeobox 2. (463 aa)
COL4A2Collagen type IV alpha 2 chain. (329 aa)
COL4A1Collagen type IV alpha 1 chain. (1586 aa)
FOXA2Forkhead box A2. (468 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
NCOA1Nuclear receptor coactivator. (1410 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (820 aa)
GLI3GLI family zinc finger 3. (1590 aa)
TGFAEGF-like domain-containing protein. (284 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (807 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (995 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (340 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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