(11 nodes) (....) Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology. network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	MYH2	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1940 aa)
	FNIP1	Folliculin interacting protein 1. (1168 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (506 aa)
	DAG1	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (892 aa)
	MYH8	Myosin-8; Muscle contraction. (1940 aa)
	MYH1	Myosin-1; Muscle contraction. (1953 aa)
	MYH3	Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
	MYH4	Myosin-4; Muscle contraction. (1939 aa)
	UTRN	Utrophin. (3432 aa)
	MYH6	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
	FKRP	Fukutin related protein. (560 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAG1	FKRP	ENSCAFP00000016488	ENSCAFP00000061358	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	Fukutin related protein.	0.877
DAG1	MYF5	ENSCAFP00000016488	ENSCAFP00000008695	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.414
DAG1	UTRN	ENSCAFP00000016488	ENSCAFP00000039395	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	Utrophin.	0.963
FKRP	DAG1	ENSCAFP00000061358	ENSCAFP00000016488	Fukutin related protein.	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	0.877
FKRP	UTRN	ENSCAFP00000061358	ENSCAFP00000039395	Fukutin related protein.	Utrophin.	0.558
MYF5	DAG1	ENSCAFP00000008695	ENSCAFP00000016488	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...]	0.414
MYF5	MYH1	ENSCAFP00000008695	ENSCAFP00000025847	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myosin-1; Muscle contraction.	0.464
MYF5	MYH3	ENSCAFP00000008695	ENSCAFP00000025874	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.721
MYF5	MYH4	ENSCAFP00000008695	ENSCAFP00000025934	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myosin-4; Muscle contraction.	0.512
MYF5	MYH6	ENSCAFP00000008695	ENSCAFP00000053932	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.536
MYF5	MYH8	ENSCAFP00000008695	ENSCAFP00000025828	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Myosin-8; Muscle contraction.	0.479
MYF5	UTRN	ENSCAFP00000008695	ENSCAFP00000039395	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Utrophin.	0.563
MYH1	MYF5	ENSCAFP00000025847	ENSCAFP00000008695	Myosin-1; Muscle contraction.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.464
MYH1	MYH2	ENSCAFP00000025847	ENSCAFP00000025869	Myosin-1; Muscle contraction.	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	0.644
MYH1	MYH3	ENSCAFP00000025847	ENSCAFP00000025874	Myosin-1; Muscle contraction.	Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.726
MYH1	MYH4	ENSCAFP00000025847	ENSCAFP00000025934	Myosin-1; Muscle contraction.	Myosin-4; Muscle contraction.	0.573
MYH1	MYH6	ENSCAFP00000025847	ENSCAFP00000053932	Myosin-1; Muscle contraction.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.654
MYH1	MYH8	ENSCAFP00000025847	ENSCAFP00000025828	Myosin-1; Muscle contraction.	Myosin-8; Muscle contraction.	0.546
MYH2	MYH1	ENSCAFP00000025869	ENSCAFP00000025847	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	Myosin-1; Muscle contraction.	0.644
MYH2	MYH3	ENSCAFP00000025869	ENSCAFP00000025874	Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).	Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.726