STRINGSTRING
RICTOR RICTOR TSC1 TSC1 SLC7A5 SLC7A5 RANBP17 RANBP17 ITFG2 ITFG2 INSR INSR SESN2 SESN2 LPIN1 LPIN1 BECN1 BECN1 RHEB RHEB EIF4E EIF4E SESN1 SESN1 NCOR1 NCOR1 PPARA PPARA PPARG PPARG KPTN KPTN GRB10 GRB10 KLF4 KLF4 ATF4 ATF4 DEPTOR DEPTOR ATG12 ATG12 ATP4A ATP4A ATG7 ATG7 LARS1 LARS1 IGF1 IGF1 LARS2 LARS2 TFEB TFEB ULK1 ULK1 SLC38A9 SLC38A9 CASTOR1 CASTOR1 SLC3A2 SLC3A2 TFE3 TFE3 FLCN FLCN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RICTORRPTOR independent companion of MTOR complex 2. (1699 aa)
TSC1TSC complex subunit 1. (1169 aa)
SLC7A5Uncharacterized protein. (488 aa)
RANBP17RAN binding protein 17. (1108 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (487 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
SESN2Sestrin 2. (485 aa)
LPIN1Lipin 1. (1014 aa)
BECN1Beclin 1. (471 aa)
RHEBRas homolog, mTORC1 binding. (232 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
SESN1Sestrin 1. (658 aa)
NCOR1Nuclear receptor corepressor 1. (2542 aa)
PPARAPeroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (568 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
KPTNKaptin, actin binding protein. (539 aa)
GRB10Growth factor receptor bound protein 10. (546 aa)
KLF4Kruppel like factor 4. (469 aa)
ATF4Activating transcription factor 4. (350 aa)
DEPTORDEP domain containing MTOR interacting protein. (408 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
ATP4APotassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1041 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1224 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
LARS2Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1004 aa)
TFEBTranscription factor EB. (566 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1004 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
SLC3A2Aamy domain-containing protein. (533 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (571 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (748 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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